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ISBN: 3030540618 303054060X 9783030540609 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,
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This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology. .
Biotechnology. --- Immunology. --- Nucleic acids. --- Nanochemistry. --- Chromatography. --- Biomedical engineering. --- Nucleic Acid Chemistry. --- Biomedical Engineering and Bioengineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Analysis, Chromatographic --- Chromatography --- Chemistry, Analytic --- Phase partition --- Nanoscale chemistry --- Nanoscience --- Polynucleotides --- Biomolecules --- Immunobiology --- Life sciences --- Serology --- Chemical engineering --- Genetic engineering --- Analytical chemistry --- Oligonucleotides. --- Nucleotides
Book
ISBN: 3030296466 3030296458 9783030296452 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,
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This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in vitro and in vivo selection. Unlike ribozymes, DNAzymes do not occur in nature. Although the catalytic activity of nucleic acid enzymes is usually much slower than that of proteins, nucleic acid enzymes with comparable catalytic activity have been obtained using stringent selection processes. The key advantages of these enzymes: they are e.g. smaller, easier to produce and purify than proteins, and can withstand denaturation, e.g. by heat. Over the last few years, the number of publications on the applications of enzymatic nucleic acids has grown steadily. Summarizing the fundamentals and applications of these acids, this book will not only be an excellent resource for experts in the field but will also guide young researchers just starting out in this significant area.
Biochemical engineering. --- Nucleic acids. --- Enzymes. --- Biochemical Engineering. --- Nucleic Acid Chemistry. --- Enzymology. --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Polynucleotides --- Biomolecules --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Enzymes --- Chemistry --- Biochemical engineering --- Nucleic acids
Book
ISBN: 9783030540616 Year: 2020 Publisher: Cham Springer International Publishing :Imprint: Springer
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Chemical structure --- Fysicochemical separation methods --- Chemistry --- Genetics --- Human biochemistry --- Immunology. Immunopathology --- Biotechnology --- immunologie --- moleculen --- nucleïnezuren --- medische biochemie --- nanotechniek --- chemie --- biotechnologie --- atomen --- chromatografie
Book
ISBN: 9783030296469 Year: 2020 Publisher: Cham Springer International Publishing :Imprint: Springer
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Genetics --- Enzymology --- Biochemical engineering --- nucleïnezuren --- bio-engineering --- biochemie --- enzymen
Multi
ISBN: 9783030540616 Year: 2020 Publisher: Cham Springer International Publishing :Imprint: Springer
Abstract | Keywords | Export | Availability | Bookmark
Loading...Choose an application
- Reference Manager
- EndNote
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This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology. .
Chemical structure --- Fysicochemical separation methods --- Chemistry --- Genetics --- Human biochemistry --- Immunology. Immunopathology --- Biotechnology --- immunologie --- moleculen --- nucleïnezuren --- medische biochemie --- nanotechniek --- chemie --- biotechnologie --- atomen --- chromatografie
Multi
ISBN: 9783030296469 Year: 2020 Publisher: Cham Springer International Publishing :Imprint: Springer
Abstract | Keywords | Export | Availability | Bookmark
Loading...Choose an application
- Reference Manager
- EndNote
- RefWorks (Direct export to RefWorks)
This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in vitro and in vivo selection. Unlike ribozymes, DNAzymes do not occur in nature. Although the catalytic activity of nucleic acid enzymes is usually much slower than that of proteins, nucleic acid enzymes with comparable catalytic activity have been obtained using stringent selection processes. The key advantages of these enzymes: they are e.g. smaller, easier to produce and purify than proteins, and can withstand denaturation, e.g. by heat. Over the last few years, the number of publications on the applications of enzymatic nucleic acids has grown steadily. Summarizing the fundamentals and applications of these acids, this book will not only be an excellent resource for experts in the field but will also guide young researchers just starting out in this significant area.
Genetics --- Enzymology --- Biochemical engineering --- nucleïnezuren --- bio-engineering --- biochemie --- enzymen
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