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Small ring compounds in organic synthesis
Authors: ---
ISBN: 0387163077 3540163077 0387166629 3540166629 354018368X 038718368X 0387524223 3540524223 3540664718 3540397698 3540469842 3540398465 3540479244 3540482555 9783540166627 9783540163077 9783540183686 9780387524221 9783540524229 9783540664710 Year: 2000 Volume: 135 Publisher: Berlin Springer

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Abstract

This current and five previous volumes (Volumes 133, 135, 144, 155, 178) convincingly demonstrate the vast applications of small rings in modern Organic Synthesis. Such applications range from total syntheses of cyclopropyl-group-containing natural products and non-natural biologically active compounds or compounds with other important properties (e.g. liquid crystalline) via syntheses of cyclopropyl analogues of natural and non-natural physiologically active compounds, e.g. peptidomimetics, to the use of cyclopropyl groups as reactive subunits in so-called composite functional groups. This current volume covers a survey of the wide range of biological activities of cyclopropyl-containing compounds, up-to-date comprehensive reviews on the multiple applicabilities of two multifunctional small ring building blocks - methyl-2-chloro-2-cyclopropylidene acetate and bicyclopropylidene - in Organic Synthesis as well as a striking new approach to cyclopentenones from easily accessible 1-ethynylcyclopropanols, which is rather general and favorably complements other cyclopentenone syntheses.

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