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"This book is the most comprehensive and complete treatise on nucleic acid therapeutic products, including mRNA vaccines, their manufacturing, formulations, and testing for safety and efficacy testing. Details include cGMP-compliant manufacturing and regulatory filing steps. A new concept of "biosimilar" mRNA vaccine is presented to secure fast approval of copies of mRNA vaccines. Projections of financial plans to establish RNA manufacturing facilities are provided, along with details of supply chain management. Finally, the future of nucleic acid products in gene therapy and other newer applications is presented, along with a perspective that all new vaccines will be the nucleic acid type that will further provide first-time prevention of autoimmune disorders. It is projected that both big pharma and startups will enter this field, and we can expect significant additions to our drug armamentarium soon"--

mRNA Vaccines --- Drug Development --- Technology, Pharmaceutical --- RNA, Messenger --- Vaccins à ARN messager --- ARN messagers --- Innovations pharmaceutiques --- standards. --- methods. --- therapeutic use. --- Emploi en thérapeutique --- Vaccins à ARN messager. --- Innovations pharmaceutiques. --- Emploi en thérapeutique. --- Vaccins à ARN messager. --- Emploi en thérapeutique.

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L’ARN messager a été découvert au tout début des années 1960 par François Jacob, Jacques Monod et Sydney Brenner. Il a valu aux deux premiers le prix Nobel. Au cours de l’année 2020, alors que l’humanité tout entière était menacée par le Covid-19, on a découvert et mis au point, en à peine dix mois, une série de vaccins utilisant précisément cet ARN messager et offrant l’espoir de sortir de cette terrible pandémie. Ce livre est le premier à raconter cette extraordinaire aventure non seulement scientifique, technologique et industrielle, mais aussi humaine. Fabrice Delaye en a rencontré les acteurs importants – plus de quarante, dont Stéphane Bancel, le patron de Moderna, Ingmar Hoerr, le fondateur de CureVac, Kati Karikó, la chercheuse à l’origine du vaccin de Pfizer-BioNTech, et Moncef Slaoui, le patron de l’opération Warp Speed aux États-Unis. Un livre haletant, où l’on va de découverte en découverte, en suivant sur plus de trente ans le parcours de scientifiques et d’entrepreneurs : courage et ténacité, inventivité de chercheurs visionnaires et audace des start-up. Après la démonstration des vaccins à ARN, une véritable révolution médicale est en marche, ouvrant des voies thérapeutiques nouvelles pour le cancer et d’autres maladies. Fabrice Delaye est journaliste en Suisse pour Heidi. news. Il suit depuis vingt-cinq ans l’univers des sciences, de la technologie et des start-up. Patrick Aebischer est président émérite de l’École polytechnique fédérale de Lausanne. Médecin et professeur de neurosciences, il est l’auteur de plus de deux cents publications scientifiques et fondateur de nombreuses start-up.

Messenger RNA --- Pharmaceutical technology --- Vaccination --- ARN messagers. --- Vaccins antiviraux. --- Industrie pharmaceutique. --- Pharmacie --- ARN messager --- Vaccins. --- Innovations technologiques. --- usage thérapeutique. --- Viral vaccines --- Pharmaceutical industry --- RNA, Messenger --- Vaccines --- Drug Industry --- therapeutic use --- Innovations pharmaceutiques.

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Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation.

Messenger RNA. --- Genetic regulation. --- Eukaryotic cells. --- Nucleases. --- ARN messager --- Régulation génétique --- Cellules eucaryotes --- Régulation génétique --- Eucaryotic cells --- Gene expression --- Gene expression regulation --- Gene regulation --- Informational RNA --- Messenger ribonucleic acid --- mRNA --- Protein transcript --- Protein transcripts --- Template RNA --- Regulation --- Esterases --- Cells --- Protista --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- RNA

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Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation.