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Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

signaling --- pharmacological manipulation --- cyclic adenosine monophosphate --- Disease --- Therapeutic applications --- Homeostasis --- cAMP --- Cellular function

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Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

signaling --- pharmacological manipulation --- cyclic adenosine monophosphate --- Disease --- Therapeutic applications --- Homeostasis --- cAMP --- Cellular function

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Blood Platelets --- Purinergic P2 Receptor Antagonists --- Thrombin --- Thromboembolism --- Adenosine Monophosphate --- Platelet Activation --- metabolism --- biosynthesis --- drug therapy --- pharmacology --- physiology

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Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering

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Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Research & information: general --- Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering