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Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

Life Sciences. --- Embryology. --- Reproductive Medicine. --- Cytogenetics. --- Life sciences. --- Human genetics. --- Sciences de la vie --- Génétique humaine --- Embryologie --- Human embryo -- Transplantation. --- Human reproduction -- Immunological aspects. --- Spermatozoa -- Motility -- Disorders. --- Biology --- Health & Biological Sciences --- Biophysics --- Spermatozoa --- Human embryo --- Human reproduction --- Motility --- Disorders. --- Transplantation. --- Immunological aspects. --- Reproductive immunology --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Motility disorders, Spermatozoal --- Spermatozoal motility disorders --- Reproductive medicine. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Cytology --- Genetics --- Biosciences --- Sciences, Life --- Science --- Embryology --- Development --- Health aspects --- Embryo transplantation --- Human reproductive technology --- Infertility, Male --- Heredity, Human --- Human biology --- Physical anthropology --- Semen --- Embryo Implantation --- Aneuploidy. --- Infertility, Male. --- immunology. --- abnormalities. --- Aneuploid --- Aneuploid Cell --- Aneuploid Cells --- Aneuploidies --- Aneuploids --- Cell, Aneuploid --- Cells, Aneuploid --- Aneugens --- Sub-Fertility, Male --- Subfertility, Male --- Sterility, Male --- Male Infertility --- Male Sterility --- Male Sub-Fertility --- Male Subfertility --- Sub Fertility, Male --- Sperm Injections, Intracytoplasmic