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Pancreas --- Cancer. --- Pancreatic Neoplasms --- Drug Resistance, Neoplasm. --- drug therapy. --- Antineoplastic Agent Resistance --- Neoplasm Drug Resistance --- Resistance, Antineoplastic Agent --- Resistance, Antineoplastic Drug --- Antibiotic Resistance, Neoplasm --- Antineoplastic Drug Resistance --- Drug Resistance, Antineoplastic

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Generative organs, Female --- Drug resistance in cancer cells. --- Cancer. --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer cells --- Gynecologic cancer --- Cancer in women --- Genital Neoplasms, Female --- Drug Resistance, Neoplasm. --- drug therapy. --- Antineoplastic Agent Resistance --- Neoplasm Drug Resistance --- Resistance, Antineoplastic Agent --- Resistance, Antineoplastic Drug --- Antibiotic Resistance, Neoplasm --- Antineoplastic Drug Resistance --- Drug Resistance, Antineoplastic

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This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

Cancer --- Neoplasm, Residual. --- Molecular aspects. --- Oncology. --- Human genetics. --- Medicine. --- Cytology. --- Drug interactions. --- Cancer Research. --- Human Genetics. --- Molecular Medicine. --- Cell Biology. --- Drug Resistance. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Interactions, Drug --- Drugs --- Side effects --- Health Workforce --- Cancer research. --- Molecular biology. --- Cell biology. --- Drug resistance. --- Resistance to drugs --- Pharmacology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Drug Resistance, Neoplasm. --- Antineoplastic Agent Resistance --- Neoplasm Drug Resistance --- Resistance, Antineoplastic Agent --- Resistance, Antineoplastic Drug --- Antibiotic Resistance, Neoplasm --- Antineoplastic Drug Resistance --- Drug Resistance, Antineoplastic --- Cellular Biology --- Cytology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Medicine, Molecular --- Medicines, Molecular --- Molecular Medicines --- Genetics, Medical --- Genetics, Human

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Neoplasms. --- Patient-Specific Modeling. --- Precision Medicine. --- Tumor Microenvironment. --- Theranostic Nanomedicine. --- Drug Resistance, Neoplasm. --- Antineoplastic Agent Resistance --- Neoplasm Drug Resistance --- Resistance, Antineoplastic Agent --- Resistance, Antineoplastic Drug --- Antibiotic Resistance, Neoplasm --- Antineoplastic Drug Resistance --- Drug Resistance, Antineoplastic --- Photothermal Theranostics --- Nanomedicine, Theranostic --- Nanomedicines, Theranostic --- Photothermal Theranostic --- Theranostic Nanomedicines --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Patient-Specific Computational Modeling --- Physiome --- Computational Modeling, Patient-Specific --- Modeling, Patient-Specific --- Patient Specific Computational Modeling --- Patient Specific Modeling --- Physiomes --- Models, Biological --- Precision Medicine --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Enginyeria biomèdica --- Resistència als medicaments --- Farmacoresistència --- Farmacologia --- Resistència a la insulina --- Efecte dels medicaments sobre els microorganismes --- Carcinomes --- Malalties neoplàstiques --- Neoplàsies --- Neoplasmes --- Patologia --- Càncer --- Feocromocitoma --- Fibromes --- Marcadors tumorals --- Mesotelioma --- Miomes --- Pòlips (Patologia) --- Sarcoïdosi --- Sarcoma --- Teratoma --- Tumors de parts toves --- Tumors en els animals --- Classificació de tumors --- Oncologia --- Quistos --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Enginyeria de teixits --- Materials biomèdics --- Aparells i instruments mèdics --- Biomedical engineering. --- Research. --- Treatment. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer therapy --- Cancer treatment --- Cancer research --- Therapy

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Immunology. Immunopathology --- Oncology. Neoplasms --- Pharmacology. Therapy --- Pharmacology --- Pharmaceutical Preparations --- Biological Science Disciplines --- Antineoplastic Agents. --- Immunosuppressive Agents. --- Neoplasms --- Immunosuppressants --- Agents, Immunosuppressive --- Antirheumatic Agents --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- drug therapy. --- Antineoplastic agents --- Immunosuppressive agents --- NEOPLASMS --- drug therapy --- Antineoplastic agents. --- Immunosuppressive agents. --- Drug therapy. --- Immunosuppressant --- Immunosuppressive Agent --- Agent, Immunosuppressive --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Chemotherapy Agent, Cancer --- Chemotherapy Drug, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Antineoplastic Agents --- Immunosuppressive Agents