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Antiparasitic agents.

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This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veter

Antiparasitic agents. --- Pharmaceutical chemistry.

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Antiparasitic agents. --- Avermectins. --- Lactones. --- Macrocyclic compounds. --- ANTIPARASITIC AGENTS --- IVERMECTIN --- PARASITOLOGY --- ANALOGS AND DERIVATIVES --- METABOLISM

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Parasitic infections are the most prevalent of human diseases, and researchers continue to face the challenge of designing drugs to successfully counteract them. Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets in malaria, trypanosomes, leishmania and amitochondrial protists. Chapters on helminths include metabolic, neuromuscular, microtubular and tegumental targets. Emphasized throughout is the design of more selective and less toxic drugs than in the past. This book will be especially relevant to medical and clinical researchers and to graduate students in parasitology, pharmacology, medicine, microbiology, and biochemistry.

Antiparasitic agents. --- Parasitic diseases --- Communicable diseases --- Medical parasitology --- Antiparasitics --- Parasiticides --- Anti-infective agents --- Chemotherapy.

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Présentation de l'éditeur : "Ce traité s'appuie sur les fondements structuraux et physicochimiques des molécules pour la connaissance des médicaments et la compréhension de leur utilisation. Le tome 2 "Antiparasiatires" du cinquième volume aborde les médicaments utilisés dans le traitement de parasitoses telles le paludisme, les amibiases, les trichomonoses, les trypanosomiases, les leishmanioses et pneumocystoses, les helminthiases (ascaridiose, oxyurose, ankylostomoses, anguillulose, bilharzioses, distomatoses, cestodoses...)."

Chemistry, Pharmaceutical --- Pharmaceutical Preparations --- Antiparasitic Agents --- Antifongiques --- Antifungal Agents --- Mycoses --- drug therapy --- Chimie pharmaceutique --- Mycoses - drug therapy