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Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Antineoplastic agents. --- Cancer -- Molecular aspects. --- Cancer -- Treatment. --- Cancer. --- Cancer --- Antineoplastic agents --- Enzyme Inhibitors --- Aza Compounds --- Cytidine --- Therapeutics --- Therapeutic Uses --- Diseases --- Azacitidine --- Protein Kinase Inhibitors --- Antineoplastic Agents --- Drug Therapy --- Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pyrimidine Nucleosides --- Pharmacologic Actions --- Ribonucleosides --- Molecular Mechanisms of Pharmacological Action --- Organic Chemicals --- Chemical Actions and Uses --- Nucleosides --- Pyrimidines --- Chemicals and Drugs --- Nucleic Acids, Nucleotides, and Nucleosides --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Medicine --- Oncology --- Health & Biological Sciences --- Molecular aspects --- Treatment --- Molecular aspects. --- Treatment. --- Cancer therapy --- Cancer treatment --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Therapy --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Haematology --- Internal medicine --- Blood --- Tumors --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Drugs --- Chemotherapy

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Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues. The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance. While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information. As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation. A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to the predictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.

Drug abusers -- Medical care. --- Drugs of abuse. --- Psychotropic drugs -- Physiological effect. --- Psychotropic drugs -- Side effects. --- Psychotropic drugs. --- Psychotropic drugs --- Drugs of abuse --- Drug abusers --- Substance-Related Disorders --- Pharmacology --- Cocaine --- Amphetamine --- Designer Drugs --- N-Methyl-3,4-methylenedioxyamphetamine --- Tropanes --- Amphetamines --- Pharmaceutical Preparations --- Biological Science Disciplines --- Diseases --- Mental Disorders --- Azabicyclo Compounds --- Phenethylamines --- Psychiatry and Psychology --- Heterocyclic Compounds, Bridged-Ring --- Alkaloids --- Chemicals and Drugs --- Natural Science Disciplines --- Aza Compounds --- Bicyclo Compounds, Heterocyclic --- Heterocyclic Compounds --- Disciplines and Occupations --- Ethylamines --- Amines --- Organic Chemicals --- Bicyclo Compounds --- Bridged Compounds --- Polycyclic Compounds --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Physiological effect --- Side effects --- Medical care --- Drug abuse --- Physiological effect. --- Treatment. --- Medicine. --- Pharmacy. --- Pharmacology. --- Pharmaceutical technology. --- Emergency medicine. --- Biomedicine. --- Pharmacology/Toxicology. --- Biomedicine general. --- Pharmaceutical Sciences/Technology. --- Medicine/Public Health, general. --- Emergency Medicine. --- Toxicology. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Chemistry --- Drugs --- Materia medica --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemicals --- Poisoning --- Poisons --- Toxicology --- Biomedicine, general. --- Health Workforce --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy