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This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

donor breast milk --- human milk --- milk analysis --- very low birth weight --- preterm --- growth --- preterm infant --- donor human milk --- formula feeding --- breastfeeding --- necrotizing enterocolitis --- breast milk --- prematurity --- immunity --- newborn --- inflammation --- colostrum administration --- premature neonates --- clinical outcomes --- intestinal resection --- short bowel syndrome --- intestinal adaptation --- microbiome --- parenteral nutrition --- hormones --- milk fat globule --- long chain polyunsaturated fatty acids --- premature infants --- neonatal --- intestine --- glycosaminoglycans --- intestinal inflammation --- bioactive --- donor milk --- gastroschisis --- intestinal atresia --- human milk fortifier --- patient empowerment --- neonatal nutrition --- communication --- product labeling --- NICU parent --- extracellular vesicle --- exosome --- immature intestine --- formula --- osmolality --- breastmilk --- late onset sepsis --- bloodstream infections --- enteric pathogens --- human milk banks --- NEC --- meta-analysis --- breast-feeding --- spontaneous intestinal perforation --- feeding --- nutrition

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The worldwide emergence of antimicrobial-resistant bacteria, specially those resistant to last-resource antibiotics, is now a common problem being defined as one of three priorities for the safeguarding of One Health by the Tripartite Alliance, which includes the World Health Organization (WHO), the Food and Agriculture Organization (FAO) and the Office International des Epizooties (OIE). Bacteria resistance profiles, together with the expression of specific virulence markers, have a major influence on the outcomes of infectious diseases. These bacterial traits are interconnected, since not only the presence of antibiotics may influence bacterial virulence gene expression and consequently infection pathogenesis, but some virulence factors may also contribute to an increased bacterial resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential for decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine. However, the role of natural environments as important components of the dissemination cycle of these strains has not been consider until recently. This Special Issue aims to publish manuscripts that contribute to the understanding of the impact of bacterial antimicrobial resistance and virulence in the three areas of the One Health triad–i.e., animal, human and environmental health.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- MRSA --- EMRSA-15 --- MLSB --- bacteremia --- bloodstream infections --- antibiotic resistance --- aquatic contamination --- probabilistic sampling --- San Francisco Estuary --- coast --- Pseudomonas --- Shewanella algae --- Vibrio parahaemolyticus --- biocide --- Listeria monocytogenes --- biofilm --- planktonic culture --- pulsed-field gel electrophoresis --- Escherichia coli --- fosfomycin --- nitrofurantoin --- antimicrobial resistance --- antibiotic susceptibility --- WGS --- phylogenetic analysis --- DNA mismatch repair system --- Salmonella Choleraesuis --- Iberian pig --- wild boar --- phylogenetic relationship --- plasmid replicon typing --- colistin --- carcass --- cfr gene --- fexA gene --- linezolid --- mutation --- pig --- public health --- S. aureus --- avian colibacillosis --- salmonellosis --- MDR --- tetA --- nisin --- mutant prevention concentration --- mutant selection window --- antimicrobial susceptibility testing --- horizontal gene transfer --- Salmonella --- reptiles --- isolation --- biofilms --- chlorhexidine gluconate --- wounds --- Gram-negative bacteria --- colonization --- infection --- clonal lineages --- resistance genes --- virulence factors --- Staphylococcus aureus --- skin and soft-tissue infections --- plasmids --- Panton–Valentine leucocidin

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This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

Research & information: general --- Biology, life sciences --- Food & society --- donor breast milk --- human milk --- milk analysis --- very low birth weight --- preterm --- growth --- preterm infant --- donor human milk --- formula feeding --- breastfeeding --- necrotizing enterocolitis --- breast milk --- prematurity --- immunity --- newborn --- inflammation --- colostrum administration --- premature neonates --- clinical outcomes --- intestinal resection --- short bowel syndrome --- intestinal adaptation --- microbiome --- parenteral nutrition --- hormones --- milk fat globule --- long chain polyunsaturated fatty acids --- premature infants --- neonatal --- intestine --- glycosaminoglycans --- intestinal inflammation --- bioactive --- donor milk --- gastroschisis --- intestinal atresia --- human milk fortifier --- patient empowerment --- neonatal nutrition --- communication --- product labeling --- NICU parent --- extracellular vesicle --- exosome --- immature intestine --- formula --- osmolality --- breastmilk --- late onset sepsis --- bloodstream infections --- enteric pathogens --- human milk banks --- NEC --- meta-analysis --- breast-feeding --- spontaneous intestinal perforation --- feeding --- nutrition

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This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion. .

Emergency medicine. --- Critical care medicine. --- Anesthesiology. --- Internal medicine. --- Surgery. --- Family medicine. --- Emergency Medicine. --- Intensive / Critical Care Medicine. --- Internal Medicine. --- General Practice / Family Medicine. --- Family practice (Medicine) --- General practice (Medicine) --- Medicine --- Physicians (General practice) --- Surgery, Primitive --- Medicine, Internal --- Anaesthesiology --- Surgery --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Sepsis --- Disease Management --- Developing Countries --- Health Services Accessibility --- Accessibility, Health Services --- Contraceptive Availability --- Health Services Geographic Accessibility --- Program Accessibility --- Access to Health Care --- Accessibility of Health Services --- Availability of Health Services --- Accessibility, Program --- Availability, Contraceptive --- Health Services Availability --- Medically Underserved Area --- Developing Nations --- Least Developed Countries --- Less-Developed Nations --- Third-World Nations --- Under-Developed Nations --- Less-Developed Countries --- Third-World Countries --- Under-Developed Countries --- Countries, Developing --- Countries, Least Developed --- Countries, Less-Developed --- Countries, Third-World --- Countries, Under-Developed --- Country, Developing --- Country, Least Developed --- Country, Less-Developed --- Country, Third-World --- Country, Under-Developed --- Developed Countries, Least --- Developed Country, Least --- Developing Country --- Developing Nation --- Least Developed Country --- Less Developed Countries --- Less Developed Nations --- Less-Developed Country --- Less-Developed Nation --- Nation, Less-Developed --- Nation, Third-World --- Nation, Under-Developed --- Nations, Developing --- Nations, Less-Developed --- Nations, Third-World --- Nations, Under-Developed --- Third World Countries --- Third World Nations --- Third-World Country --- Third-World Nation --- Under Developed Countries --- Under Developed Nations --- Under-Developed Country --- Under-Developed Nation --- Disease Managements --- Management, Disease --- Managements, Disease --- Blood Poisoning --- Poisoning, Blood --- Septicemia --- Severe Sepsis --- Pyaemia --- Pyemia --- Pyohemia --- Blood Poisonings --- Poisonings, Blood --- Pyaemias --- Pyemias --- Pyohemias --- Sepsis, Severe --- Septicemias --- Access To Medicines --- Access to Contraception --- Access to Health Services --- Access to Medications --- Access to Therapy --- Access to Treatment --- Contraception Access --- Contraceptive Access --- Medication Access --- Access To Medicine --- Access to Contraceptions --- Access to Medication --- Access to Therapies --- Access to Treatments --- Access, Contraception --- Access, Contraceptive --- Access, Medication --- Contraception, Access to --- Contraceptive Accesses --- Medication Accesses --- Medication, Access to --- Therapy, Access to --- Treatment, Access to --- Bloodstream Infection --- Bloodstream Infections --- Infection, Bloodstream --- General practice (Medicine). --- Sepsis. --- Disease Management. --- Anesthesiology --- Internal medicine