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Cytomegalovirus (CMV) is carried by 50 100% of the worlds population throughout their lives. Consequences are most readily seen in immunocompromised individuals such as organ transplant recipients, HIV-infected patients and new born infants. This book gives an in-depth view of manifestations of CMV infection in immunocompromised individuals: how it affects the immune system and how it is diagnosed and treated. The book also sheds light on the epidemiology and impact of CMV in sub-Saharan Africa, and also associations with age related disease that are more commonly seen in the western world. It particularly details a recent discovery between CMV and tumour immuno-biology. The book explores the development of a few compounds and also highlights the need to discover novel antiviral agents in future.

Cytomegalovirus infections. --- CMV infections --- Cytomegalovirus disease --- Herpesvirus diseases --- Infectious & contagious diseases

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In Cytomegalovirus Protocols (CMV), John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a powerful collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in the pathogenesis of human infectious diseases as well as their emergent therapies.

Cytomegalovirus infections --- Cytomegaloviruses --- Pathology, Cellular. --- Cellular pathology --- Cytopathology --- Pathology --- Cytodiagnosis --- Salivary gland viruses --- Herpesviruses --- CMV infections --- Cytomegalovirus disease --- Herpesvirus diseases --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cytomegalovirus --- Cytomegalovirus Infections --- Genetic Techniques --- Laboratory Manuals --- isolation & purification --- genetics

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This second edition updates the reader on the most common intrauterine transmitted viral infection, CMV. The history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed in detail. Further a section specifically dedicated to prevention measures is included to the new edition. The chapter on virus-host interaction for defense and transmission is elaborately updated.

Cytomegalovirus infections --- CMV infections --- Cytomegalovirus disease --- Herpesvirus diseases --- Treatment. --- Diagnosis. --- Microbiology. --- Emerging infectious diseases. --- Gynecology. --- Medicine. --- Medical Microbiology. --- Infectious Diseases. --- Health Promotion and Disease Prevention. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Gynaecology --- Medicine --- Generative organs, Female --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Diseases --- Health Workforce --- Medical microbiology. --- Infectious diseases. --- Gynecology . --- Health promotion. --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education

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Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Since economic aspects are gaining more and more importance in health politics, one chapter is dedicated to this issue in the context of congenital CMV infection. The content is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to also profit from it. Thus, this book is of interest for medical doctors, nurses, midwives, economists, but also for men and women who want to inform themselves about this topic.

Cytomegalovirus infections. --- Cytomegaloviruses -- Immunological aspects. --- Cytomegaloviruses. --- Cytomegalovirus infections --- Cytomegaloviruses --- Herpesviridae Infections --- DNA Virus Infections --- Virus Diseases --- Diseases --- Cytomegalovirus Infections --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Gynecology & Obstetrics --- Salivary gland viruses --- CMV infections --- Cytomegalovirus disease --- Medicine. --- Medical microbiology. --- Gynecology. --- Public health. --- Health promotion. --- Infectious diseases. --- Medicine & Public Health. --- Medical Microbiology. --- Infectious Diseases. --- Public Health. --- Health Promotion and Disease Prevention. --- Herpesviruses --- Herpesvirus diseases --- Microbiology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Gynaecology --- Generative organs, Female --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Gynecology . --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation