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Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, the book has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. * Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions * Includes highly significant topics relevant to basic and translational research, as well as tissue engineering * Emphasizes mechanical input and output of cells

Cells --- Biomechanics. --- Cellular Structures. --- Mechanotransduction, Cellular. --- Mechanical properties.

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Acid Anhydride Hydrolases --- Cellular Structures --- Cells --- Hydrolases --- Enzymes --- Anatomy --- Enzymes and Coenzymes --- Cell Membrane --- GTP Phosphohydrolases

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Pathology, Cellular --- Cytodiagnosis --- Cytodiagnosis. --- Pathology, Cellular. --- Cellular Structures --- Cells --- Tissues --- pathology. --- Cellular pathology --- Cytopathology --- Cytologic diagnosis --- Diagnosis, Cytologic --- Diagnostic cytopathology --- Cytodiagnoses --- Pathology --- Diagnosis, Laboratory --- Cytological Techniques

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Molecular biology --- Cells --- Cytology --- Molecular genetics --- Biologie moléculaire --- Cellules --- Cytologie --- Génétique moléculaire --- Cell Biology --- Molecular Biology --- Cytogenetics --- Biologie moléculaire --- Génétique moléculaire --- Molecular biology. --- Cell Cycle. --- Cell Physiological Phenomena. --- Cell Physiological Phenomena --- Cellular structures

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This is a comprehensive and up-to-date survey of mental retardation caused by genes on the X chromosome. Clinical and laboratory data on 130 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. As background, the X chromosome and the emergence of the concept of X-linked mental retardation are discussed.; X-chromosome maps show the location and mapping limits of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked mental retardation. They have described new syndromes, regionally mapped disease loci on the X chromosome, and in several cases isolated the genes responsible for X-linked syndromes.

X-linked mental retardation --- Sex Chromosome Disorders --- X Chromosome --- Genetic Diseases, Inborn --- Sex Chromosomes --- Chromosome Disorders --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Chromosomes --- Diseases --- Congenital Abnormalities --- Cellular Structures --- Genetic Structures --- Genetic Phenomena --- Cells --- Anatomy