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Chemical carcinogenesis --- -Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Congresses --- -Congresses --- Chemical induction of cancer --- Carcinogens. --- Chemical industry. --- DNA. --- DNA

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This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present kno

Chemical carcinogenesis. --- Genetic toxicology. --- Polycyclic aromatic hydrocarbons --- Benzenoid hydrocarbons --- PAHs (Chemicals) --- Polyarenes --- Polynuclear aromatic hydrocarbons --- Hydrocarbons --- Polycyclic aromatic compounds --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenicity. --- Toxicology. --- Genetic aspects

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This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.

Medicine. --- Cancer research. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Chemical carcinogenesis. --- Metals --- Physiological effect. --- Therapeutic use. --- Metals as antiseptics --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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Disease Models, Animal. --- Environmental Exposure. --- Tobacco Smoke Pollution --- Cancer --- -Carcinogens --- Chemical carcinogenesis --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Exposure, Environmental --- Environmental Exposures --- Exposures, Environmental --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Models, Biological --- Cancer causing agents --- Carcinogenic agents --- Oncogens --- Hazardous substances --- analysis. --- Genetic aspects --- Sentinel Species --- Carcinogens --- Disease Models, Animal --- Environmental Exposure --- Cancer genetics --- Cancer genes --- analysis

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Cytochrome P-450 Enzyme System --- Pharmaceutical Preparations --- Microsomes --- Oxidation-Reduction. --- Neoplasms --- metabolism. --- chemically induced. --- Chemical carcinogenesis --- -Cytochrome P-450 --- -Drugs --- -Microsomes --- -Oxygenases --- -Cells --- Protoplasm --- Ribosomes --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Cytochromes --- Metalloenzymes --- Monooxygenases --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Oxidoreductases --- Congresses --- Metabolism --- -Congresses --- -metabolism. --- -Oxidoreductases --- Cells --- -Redox --- Oxidation Reduction --- Redox --- Oxidation-Reduction --- metabolism --- chemically induced --- Neoplasms. --- Cytochrome p-450 --- Oxidation-reduction --- Pharmaceutical preparations --- -metabolism