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This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational mode

Epilepsy. --- Convulsions --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Nervous system --- Epilepsy --- Spasms --- Brain --- Developmental disabilities --- Forecasting. --- Prevention. --- Diseases --- Prevention --- Forecasting

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The recent explosive growth in the study of status epilepticus (SE), an epileptic seizure that threatens to produce new seizures, has shown that SE is not a single disease, but arises from different substrates of the brain and comprises multifaceted illnesses. In Status Epilepticus: A Clinical Perspective, a panel of senior clinicians critically reviews the many forms of SE, their causes, manifestations, methods of diagnosis, and appropriate treatments. The authors emphasize the disease as encountered by the clinician in the field and the importance of correct recognition and diagnosis. They provide for each form of SE the underlying genetic, biological, and developmental background, the pathophysiological processes, as well as the precipitating factors that lead to an episode. For the difficult problem of diagnosing nonconvulsive SE, they offer detailed syndrome classifications, differential diagnoses, descriptions of seizure "imitators," notes on unusual behavioral and cognitive manifestations, and carefully delineated clinical presentations. Additional highlights include striking EEG reproductions that provide classic examples of patients in SE, SE in very young children and neonates, and an analysis of the cellular physiology and processes occurring during SE. Comprehensive and up-to-date, Status Epilepticus: A Clinical Perspective offers the neurologic clinician an authoritative review of the diagnosis and treatment of the many forms of this most serious and challenging acute nervous system disorder.

Status Epilepticus. --- Epilepsy. --- Convulsions. --- Epilepsie --- Convulsions --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Medicine. --- Neurology. --- Medicine & Public Health. --- Brain --- Developmental disabilities --- Spasms --- Nervous system --- Epilepsy --- Diseases --- Medicine --- Neuropsychiatry --- Neurology .

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Epilepsy --- Convulsions --- Electroencephalography. --- Diagnosis. --- EEG --- Encephalography --- Brain --- Electrodiagnosis --- Electrophysiology --- Visual evoked response --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Nervous system --- Spasms --- Developmental disabilities --- Diseases --- Diagnosis

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H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a ""better understanding of the epilepsies and seek more rational methods of their prevention and treatment."" Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it shou

Epilepsy -- Congresses. --- Epilepsy. --- Pathology, Cellular -- Congresses. --- Pathology, Molecular -- Congresses. --- Epilepsy --- Brain Diseases --- Central Nervous System Diseases --- Nervous System Diseases --- Diseases --- Medicine --- Health & Biological Sciences --- Neurology --- Convulsions. --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Nervous system --- Spasms --- Brain --- Developmental disabilities --- Convulsions

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Epileptic events are now known to occur more frequently in the intensive care unit (ICU) than previously thought, a situation concealed by the many variables operating at any given moment in the ICU's environment of heavy drug and sedative use. In Seizures in Critical Care: A Guide to Diagnosis and Therapeutics, a panel of international ICU and epilepsy physicians and researchers detail the epileptic phenomena that occur in the complex environment of the ICU. Focusing on the central nervous system, the authors systematically examine the most up-to-date evidenced-based data regarding ICU seizures, including their most frequent causes, their pathophysiology, their clinical presentation, and the diagnostic evaluation needed to confirm their presence. They also discuss the challenges and specifics of the management of ICU seizures, reviewing the new antiepileptics and their interaction with other ICU medications, drugs with epileptogenic properties used in the ICU, and the role of the new enterally available antiepileptics in treating such seizures. Numerous tables summarize drug interactions, neuroimages reveal common ICU seizure etiologies, and multiple electroencephalographic recordings demonstrate clinical or subclinical seizures in ICU patients. Authoritative and uniquely practical, Seizures in Critical Care: A Guide to Diagnosis and Therapeutics offers hospital-based medical professionals and ICU specialists, for the first time, a systematic survey of, and reference guide to, the diagnosis and treatment of epileptic seizures in the ICU.

Convulsions. --- Critical care medicine. --- Intensive care --- Intensive medicine --- Medicine --- Emergency medicine --- Intensive care units --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Nervous system --- Epilepsy --- Spasms --- Diseases --- Neurology. --- Emergency medicine. --- Intensive / Critical Care Medicine. --- Emergency Medicine. --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Neuropsychiatry --- Neurology .