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Therapeutic Hypothermia in Brain Injury
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ISBN: 953510960X 9535153501 Year: 2013 Publisher: IntechOpen

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Abstract

This book describes the evidence behind the application of Therapeutic Hypothermia on patients with injury to the brain and spinal cord, that includes ischemia reperfusion after cardiac arrest or asphyxiation, traumatic brain injury, acute ischemic stroke, hemorrhagic stroke, refractory intracranial hypertension, cerebral edema in acute liver failure, subarachnoid hemorrhage, as well as spinal cord injury. This book discusses the mechanisms by which therapeutic hypothermia can mitigate the pathophysiologies responsible for secondary brain injury, and provides information to help guide this treatment with regard to timing, depth, duration, and management of side-effects. The book also discusses the methods and technologies used to induce and maintain therapeutic hypothermia. It also describes how hypothermia can influence the ability to prognosticate these injured patients and provides grounds for future directions in the application of and research with therapeutic hypothermia.

Therapeutic hypothermia
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ISBN: 1280816090 9786610816095 038725403X 0387254021 1441937935 Year: 2005 Volume: 4 Publisher: New York : Springer,

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The use of hypothermia for a variety of therapeutic purposes has a long and erratic history. Hypothermia was used for protection and preservation of the heart and entire organism during planned operative ischemia. Attempts were also made to use hypothermia for resuscitation from cardiac arrest and for management of head trauma. Therapeutic Hypothermia will provide a review of the subject, in particular, resuscitative hypothermia and include known mechanisms of action and results from both mechanistic and outcome laboratory studies and clinical trials. Cooling methods and potential side effects of hypothermia will be addressed as well as recommendations for future laboratory and clinical research. This volume will be of interest to both the researcher interested in therapeutic hypothermia as well as the clinician interested in the potential use of therapeutic hypothermia in their patient population. Samuel A. Tisherman is an Associate Professor in the Department of Surgery, the University of Pittsburgh, Pennsylvania, USA. Fritz Sterz is a Professor in Emergency Medicine at the University of Vienna, Vienna, Austria.

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