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Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

Biomedicine. --- Neurosciences. --- Cell Biology. --- Developmental Biology. --- Medicine. --- Cytology. --- Developmental biology. --- Médecine --- Neurosciences --- Cytologie --- Biologie du développement --- Cyclin-Dependent Kinases -- antagonists and inhibitors. --- Cyclin-dependent kinases -- Inhibitors -- Therapeutic use. --- Cyclin-Dependent Kinases -- therapeutic use. --- Cyclin-dependent kinases. --- Nervous system -- Degeneration -- Etiology. --- Nervous system -- Degeneration -- Treatment. --- Neurodegenerative Diseases -- drug therapy. --- Nervous System Diseases --- Cell Cycle Proteins --- Proline-Directed Protein Kinases --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Proteins --- Diseases --- Peptides --- Protein Kinases --- Phosphotransferases (Alcohol Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Cyclin-Dependent Kinases --- Neurodegenerative Diseases --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Cyclin-dependent kinases --- Nervous system --- Inhibitors --- Therapeutic use. --- Degeneration --- Etiology. --- Treatment. --- CDK proteins --- Cyclin-dependent protein kinases --- Cell biology. --- Organs (Anatomy) --- Protein kinases --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences