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This richly detailed study highlights the last two decades of the life of Mary Baker Eddy, a prominent religious thinker whose character and achievement are just beginning to be understood. It is the first book-length discussion of Eddy to make full use of the resources of the Mary Baker Eddy Collection in Boston. Rolling Away the Stone focuses on her long-reaching legacy as a Christian thinker, specifically her challenge to the materialism that threatens religious belief and practice.

Materialism. --- Physicalism --- Animism --- Philosophy --- Positivism --- Dualism --- Idealism --- Mechanism (Philosophy) --- Monism --- Realism --- Eddy, Mary Baker, --- Ėddi, Mėri Bėker, --- Glover, Mary Baker,

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Drug–drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb–drug or food–drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions.

Research & information: general --- Biology, life sciences --- tadalafil --- ticagrelor --- drug-drug interaction --- pharmacokinetics --- plasma concentration --- CYP3A4 --- Loxoprofen --- CYP3A --- Dexamethasone --- Ketoconazole --- CYP2D6 --- O-desmethyltramadol --- physiologically-based pharmacokinetics --- tramadol --- (‒)-sophoranone --- CYP2C9 --- potent inhibition --- in vitro --- in vivo --- drug interaction --- low permeability --- high plasma protein binding --- biflavonoid --- cytochrome P450 --- drug interactions --- selamariscina A --- uridine 5′-diphosphoglucuronosyl transferase --- tissue-specific --- systemic exposure --- P-glycoprotein (P-gp) --- organic anion transporting polypeptide 1A2 (OATP1A2) --- Rumex acetosa --- fexofenadine --- chronic kidney disease --- drug–drug interactions --- polypharmacy --- adverse drug reactions --- Lexicomp --- subset analysis --- signal detection algorithms --- spontaneous reporting systems --- mechanism-based inhibition --- competitive inhibition --- non-competitive inhibition --- substrate --- inhibitor --- cytochromes P450 --- OATP1B1 --- OATP1B3 --- tyrosine kinase inhibitors --- drug-drug interactions --- migraine --- lasmiditan --- gepants --- monoclonal antibodies --- CYP1A1 --- CYP1A2 --- drug–drug interaction --- expression --- metabolism --- regulation --- drug transporter --- ubiquitination --- ixazomib --- DDI --- computational prediction --- in silico --- QSAR --- drug metabolism --- ADME --- CYP --- metabolic DDI --- P450 --- 1A2 --- 2B6 --- 2C19 --- 2C8 --- 2C9 --- 2D6 --- 3A4

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In The Sufi Doctrine of Man , Richard Todd examines the life and thought of Ibn 'Arabī's chief disciple, Ṣadr al-Dīn al-Qūnawī (13th century C.E.). Making use of manuscript sources, he analyzes and contextualizes Qūnawī's esoteric vision of the nature and purpose of human existence, a doctrine which incorporates core elements of Qūnawī's metaphysics, cosmology, psychology, and eschatology. Qūnawī's thought is placed in relation to Ibn 'Arabī's and that of the Ikhwān al-Ṣafā', and his interaction with the Avicennian tradition is explored by focusing on his dialogue with the philosopher al-Ṭūsī. Although not as famous as his master, Qūnawī is shown to have been a sophisticated metaphysician in his own right, who had a major impact on Sufi thought.

Theological anthropology --- Sufis --- Sufism. --- Sofism --- Mysticism --- Man (Islam) --- Islam. --- Islam --- Ṣadr al-Dīn al-Qūnawī, Muḥammad ibn Isḥāq, --- Konevi, Sadreddin, --- Konevı̂, Sadrüddı̂n Muhammed, --- Kounawy, Sadr el-Deen, --- Muḥammad ibn Isḥāq al-Qūnawī, --- Muḥammad ibn Isḥāq Ṣadr al-Dīn al-Qūnawī, --- Muḥammad ibn Isḥāq Ṣadraddīn al-Qōnawī, --- Qōnawī, Muḥammad ibn Isḥāq Ṣadraddīn, --- Qūnawī, Muḥammad ibn Isḥāq, --- Qunawi, Sadruddin, --- Sadr el-Deen el-Kounawy, --- Sadreddin Konevi, --- Sadrüddı̂n Muhammed el-Konevı̂, --- صدر الدين القونوي --- صدر الدين القونوي، محمد بن إسحاق، --- صدر الدين القونوي، محمد بن اسحاق --- صدر الدين القونوي، محمد بن اسحاق، --- صدرالدين القونوى، محمد بن اسحاق --- صدرالدين القونوى، محمد بن اسحق --- صدرالدين قونوى، محمد بن اسحق --- محمد بن اسحق صدر الدين القونوى --- محمد بن اسحق صدر الدين القنوى --- Theological anthropology - Islam --- Sufis - Biography --- Sufism --- Ṣadr al-Dīn al-Qūnawī, Muḥammad ibn Isḥāq, - -1273 or 1274

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The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.

Medicine --- Pharmaceutical industries --- bioequivalence --- Biopharmaceutics Classification System --- in vitro --- dissolution test --- pravastatin --- oral absorption --- in silico modeling --- GastroPlus --- Phoenix WinNonlin --- pharmacokinetics --- clinical studies --- ibuprofen --- manometry --- gastrointestinal --- mechanistic modeling --- PBPK --- PBBM --- disintegration --- dissolution --- enteric-coated --- ICH --- quality control --- regional intestinal permeability --- permeation enhancers --- absorption-modifying excipients --- oral peptide delivery --- intestinal perfusion --- pharmaceutical development --- controlled release drug product --- biopharmaceutics classification system --- drug solubility --- drug permeability --- location-dependent absorption --- segregated flow intestinal model (SFM) --- traditional model (TM) --- route-dependent intestinal metabolism --- first-pass effect --- drug-drug interactions --- DDI --- in vitro in vivo extrapolations --- IVIVE --- zero-order absorption --- first-order absorption --- combined zero- and first-order absorption --- transit compartment absorption model --- in situ perfusion --- microdevices --- shape --- mucoadhesion --- colon absorption --- nutrient digestion --- nutrient absorption --- gastrointestinal hormone --- postprandial glycaemia --- energy intake --- region of the gut --- obesity --- type 2 diabetes --- Franz–PAMPA --- BCS drugs --- biomimetic membrane --- Franz cell --- passive drug transport --- BCS class IV drugs --- segmental-dependent intestinal permeability --- intestinal absorption --- oral drug delivery --- biopharmaceutics --- physiologically-based pharmacokinetic (PBPK) modeling --- furosemide --- intestinal permeability --- human colon carcinoma cell layer (Caco-2) --- hierarchical support vector regression (HSVR) --- drug absorption --- drug solubility/dissolution --- regional/segmental-dependent permeability and absorption

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Has Russia turned from “Paul to Saul” with regards to international humanitarian law (IHL)? This book aims to answer this question by contrasting the past and the present. Firstly, it offers a comprehensive account of the remarkable Russian contributions to IHL since 1850. Secondly, it analyses Russia’s current approach to IHL, drawing on a wide range of legislation, case law, diplomatic records, and military practice. Finally, the author contrasts the past and the present – not without embedding his findings in the changed context of our time. The book is aimed at international law experts as well as people interested in legal history. Its author is an IHL researcher and practitioner with extensive experience in the post-soviet world.

LBB --- Friedenssicherung, Humanitäres Völkerrecht, Menschenrechte, Russland, StIGH, Vereinte Nationen, Russia, Zar, Czar, Tsar, Sowjetunion, Soviet Union, UdSSR, USSR, humanitäres Völkerrecht, international humanitarian law, hVr, IHL , Krieg, war, Recht der bewaffneten Konflikte, law of armed conflict, Kriegsrecht, laws of war, Haager Konvention, Hague Convention, Petersburger Erklärung, St Petersburg Declaration, Friedrich Martens, Fyodor Martens, Syrien, Syria, Ostukraine, Eastern Ukraine, Tschetschenien, Chechnya, Wagner Group, Kosaken, Cossacks --- Russia. --- international humanitarian law. --- history. --- human rights. --- človekove pravice --- droits de l'homme --- derechos humanos --- ľudské práva --- prawa człowieka --- ljudska prava --- δικαιώματα του ανθρώπου --- човешки права --- inimõigused --- cilvēktiesības --- rechten van de mens --- lidská práva --- cearta an duine --- ihmisoikeudet --- direitos humanos --- људска права --- emberi jogok --- menneskerettigheder --- човекови права --- drittijiet tal-bniedem --- mänskliga rättigheter --- žmogaus teisės --- të drejtat e njeriut --- diritti umani --- drepturile omului --- Menschenrechte --- kršenje ljudskih prava --- Verletzung der Menschenrechte --- diritti fondamentali dell'uomo --- Verteidigung der Menschenrechte --- nezadatelná práva --- ανθρώπινα δικαιώματα --- nepromlčitelná práva --- pasikėsinimas į žmogaus teises --- фундаментални слободи и права на човекот и граѓанинот --- zaštita ljudskih prava --- porušování lidských práv --- atentado a los derechos humanos --- Schutz der Menschenrechte --- mbrojtje e të drejtave të njeriut --- krænkelse af menneskerettighederne --- cilvēktiesību apdraudējums --- παραβίαση των δικαιωμάτων του ανθρώπου --- violarea drepturilor omului --- aantasting van de rechten van de mens --- porušenie ľudských práv --- Beeinträchtigung der Menschenrechte --- mensenrechten --- emberi jogok védelme --- emberi jogok megsértése --- kränkning av mänskliga rättigheter --- atteinte aux droits de l'homme --- útok na ľudské práva --- ihmisoikeusloukkaus --- προσβολή των δικαιωμάτων του ανθρώπου --- attack on human rights --- protección de los derechos humanos --- cilvēktiesību aizsardzība --- bescherming van de rechten van de mens --- salvaguardia dei diritti dell'uomo --- proteção dos direitos humanos --- tilsidesættelse af menneskerettighederne --- ihmisoikeuksien suojelu --- protezione dei diritti umani --- Конвенција за заштита на човековите права и основните слободи --- skydd av mänskliga rättigheter --- violación de los derechos humanos --- cilvēktiesību pārkāpums --- ochrana ľudských práv --- žmogaus teisių apsauga --- ihmisoikeuksien uhkaaminen --- prava čovjeka --- derechos del hombre --- rispetto dei diritti dell'uomo --- schending van de rechten van de mens --- inimõiguste kaitse --- protecția drepturilor omului --- shkelje e të drejtave të njeriut --- violação dos direitos humanos --- brott mot mänskliga rättigheter --- beskyttelse af menneskerettigheder --- ochrana lidských práv --- inimõiguste ohustamine --- violation des droits de l'homme --- повреда на граѓанските права --- cenim i të drejtave të njeriut --- žmogaus teisių pažeidimas --- cilvēka pamattiesības --- граѓански слободи и права --- προστασία των δικαιωμάτων του ανθρώπου --- ofensa aos direitos humanos --- заштита на правата и слободите на граѓаните --- кршење на човековите права --- human rights violation --- violazione dei diritti umani --- protection of human rights --- inimõiguste rikkumine --- reato contro i diritti dell'uomo --- protection des droits de l'homme --- História --- ιστορία --- storja --- histori --- historie --- historia --- história --- история --- stair --- geschiedenis --- történettudomány --- povijest --- zgodovina --- histoire --- историја --- Geschichtswissenschaft --- storia --- istorija --- ajalugu --- vēsture --- istorie --- Geschichte --- historiografie --- storiografia --- dějiny národů --- historiador --- dějepis --- historická věda --- történelem --- nemzetközi humanitárius jog --- kansainvälinen humanitaarinen oikeus --- an dlí daonnúil idirnáisiúnta --- direito internacional humanitário --- diritto internazionale umanitario --- Derecho internacional humanitario --- internationell humanitär rätt --- rahvusvaheline humanitaarõigus --- medzinárodné humanitárne právo --- διεθνές ανθρωπιστικό δίκαιο --- droit international humanitaire --- międzynarodowe prawo humanitarne --- dritt umanitarju internazzjonali --- internationaal humanitair recht --- međunarodno humanitarno pravo --- mednarodno humanitarno pravo --- humanitäres Völkerrecht --- mezinárodní humanitární právo --- tarptautinė humanitarinė teisė --- drept internațional umanitar --- международно хуманитарно право --- international humanitær ret --- starptautiskās humanitārās tiesības --- jus in bello --- internationales humanitäres Recht --- MHP --- law in war --- THT --- DIU --- DIH --- ΔΑΔ --- ius in bello --- humanitær folkeret --- DDI --- IHL --- humanitäres Kriegsvölkerrecht --- IHR --- Rusland --- Ryssland --- Rusko --- An Rúis --- Русија --- ir-Russja --- Rusija --- Venäjä --- Ρωσία --- Rusia --- Oroszország --- die Russische Föderation --- Venemaa --- Russie --- Русия --- Krievija --- Rússia --- Rosja --- Russia --- Russische Föderation --- Venäjän federaatio --- Federata Ruse --- Ruská federace --- Fédération de Russie --- Federacja Rosyjska --- Ruská federácia --- Krievijas Federācija --- Venemaa Föderatsioon --- Russische Federatie --- Russian Federation --- il-Federazzjoni Russa --- Ruska federacija --- Den Russiske Føderation --- Federația Rusă --- Federação Russa --- Federazione russa --- RSFSR --- Ryska federationen --- Orosz Föderáció --- Руска Федерација --- Rußland --- Руска федерация --- Rusijos Federacija --- Federación de Rusia --- Russland