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This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.
Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Pathology. --- Pharmacology/Toxicology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic
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This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.
Pediatric neurology --- Brain --- Neurosciences. --- Diagnosis. --- Diseases. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Brain diseases --- Psychology, Pathological --- Diagnosis --- Malalties neurodegeneratives --- Degeneració axònica --- Degeneració de Nissl --- Degeneració del sistema nerviós --- Degeneració nerviosa --- Degeneració neuronal --- Degeneració retrògrada --- Reacció axònica --- Reacció primària de Nissl --- Degeneració (Patologia) --- Malalties del sistema nerviós --- Malaltia d'Alzheimer --- Malaltia de Parkinson --- Regeneració del sistema nerviós
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This book reviews normal thymic structure and covers the histomorphology of benign and malignant tumors and rare lesions of the thymus, with detailed descriptions of over 300 full color photomicrographs accompanied by relevant clinical and radiology photographs and anatomical drawings. It includes chapters on the surgical pathology and cytology of thymic lesions (which is rarely described in the available literature), and all grades and stages of the most common thymic lesions. Written and edited by leading experts on pathology, the book highlights the expanded role of pathologists in patient care for thymic lesions. It will help students to understand thymic cytology and surgical pathology in detail and enable them to answer questions on thymic surgical resections and cytology cases in their pathology post-graduation examination. In addition, the book offers a comprehensive, richly illustrated guide to thymic pathology for clinicians, practicing pathologists, post-graduate residents and students alike.
Pathology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Thymus --- Tumors --- Thymus gland --- Endocrine glands --- Lymphoid tissue --- Quistos --- Patologia --- 650 --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Colesteatoma --- Equinococcosi
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This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.
Pathology. --- Hematology. --- Oncology . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Medul·la òssia --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Sistema immunitari --- Trastorns mieloproliferatius
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Degenerative conditions of the knee place an increasing burden on health economies and lead to pain and functional loss for sufferers. Although arthroplasty may not offer a level of functional restoration that meets all patients’ expectations, joint preservation through osteotomy is a viable option in younger, more physically active patients. This volume is a comprehensive technical guide to performing knee-preserving surgery to treat degenerative conditions and malalignment-associated knee instability. Drawing on their extensive experience of these procedures, the authors provide valuable insights into identifying patients who may benefit, as well as planning and performing the procedures with a high degree of precision, and explaining the results that can be achieved. This book both initiates novices and provides technical tips for experienced surgeons, and as such is an indispensible resource for all clinicians who treat patients with knee conditions.
Orthopedics. --- Sports medicine. --- Rheumatology. --- Surgical Orthopedics. --- Sports Medicine. --- Internal medicine --- Connective tissues --- Joints --- Athletic medicine --- Athletics --- Medicine and sports --- Physical education and training --- Sports --- Medicine --- Sports sciences --- Orthopaedics --- Orthopedia --- Surgery --- Diseases --- Medical aspects --- Malalties del genoll --- Osteotomia --- Degeneració (Patologia) --- Artrosi --- Artritis degenerativa --- Osteoartritis --- Osteoartrosi deformant --- Reumatisme articular degeneratiu --- Osteoartrosi --- Malalties de les articulacions --- Reumatisme --- Artritis --- Malalties dels genolls --- Genoll --- Malalties degeneratives --- Trastorns degeneratius --- Patologia --- Malalties neurodegeneratives --- Cirurgia dels ossos
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Knee --- Diseases. --- Malalties del genoll --- Artrosi --- Terapèutica --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Artritis degenerativa --- Osteoartritis --- Osteoartrosi deformant --- Reumatisme articular degeneratiu --- Osteoartrosi --- Degeneració (Patologia) --- Malalties de les articulacions --- Reumatisme --- Artritis --- Malalties dels genolls --- Genoll
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This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.
Neurology --- Medicine --- Health & Biological Sciences --- Nervous system --- Diseases. --- Medical neurology --- Nerves --- Neuropathology --- Diseases --- Neurologic disorders --- Neurological disorders --- Neurology. --- Geriatrics. --- Geriatrics/Gerontology. --- Gerontology --- Older people --- Neuropsychiatry --- Health and hygiene --- Neurology . --- Neurologia. --- Sistema nerviós --- Degeneration --- Degeneració. --- Malalties --- Geriatria --- Malalties del sistema nerviós --- Malalties neurològiques --- Nervis --- Neuropatologia --- Degeneració axònica --- Degeneració de Nissl --- Degeneració retrògrada --- Malalties neurodegeneratives --- Reacció axònica --- Reacció primària de Nissl --- Degeneració (Patologia) --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Medicina --- Neuropsiquiatria --- Degeneration and regeneration
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This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.
Nervous system --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration. --- Degeneration and regeneration --- Pharmacology. --- Nanotechnology. --- Neurology . --- Neurosciences. --- Pharmacology/Toxicology. --- Neurology. --- Molecular technology --- Nanoscale technology --- High technology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Medicine --- Neuropsychiatry --- Physiological effect --- Diseases --- Malalties neurodegeneratives --- Degeneració axònica --- Degeneració de Nissl --- Degeneració del sistema nerviós --- Degeneració nerviosa --- Degeneració neuronal --- Degeneració retrògrada --- Reacció axònica --- Reacció primària de Nissl --- Degeneració (Patologia) --- Malalties del sistema nerviós --- Malaltia d'Alzheimer --- Malaltia de Parkinson --- Regeneració del sistema nerviós
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This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems. .
Pathology. --- Oncology . --- Surgery. --- Oncology. --- Surgery, Primitive --- Medicine --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Breast Neoplasms --- pathology. --- Breast --- Diagnosis. --- Mama --- Càncer de mama --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Càncer de pit --- Càncer --- Malalties de la mama --- Càncer ginecològic --- Mames --- Mamella --- Mamelles --- Pit --- Pits --- Sines --- Glàndules mamàries --- Alletament --- Llet materna
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This book covers neoplastic and non-neoplastic pulmonary diseases, supplying essential information for the most common pulmonary diseases as well as many of the rarer ones. Organized around disease entities and presented in outline form, this book provides easy access to the essential facts and is illustrated with plentiful figures. The essential pathology, radiology and bronchoscopic technologies are discussed, as well as the tools needed to facilitate the most specific diagnoses and thus the most appropriate therapies. Each chapter also provides a list of suggested readings to guide further study. Written for a broad audience of clinicians who encounter these diseases in their everyday practice, this book serves specialists in pulmonary medicine and internal medicine, as well as general surgical pathologists who encounter these diseases as pulmonary specimens and who use this information for definitive evaluation and diagnoses of these entities, especially in small biopsies and cytopathology specimens. Pulmonary Disease: Pathology, Radiology, Bronchoscopy brings together the essential clinical, radiologic and pathologic insights for the major diseases of the lung, emphasizing the diagnostic criteria needed to ensure accurate diagnoses from small specimens.
Pathology. --- Respiratory organs—Diseases. --- Pneumology/Respiratory System. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Lungs --- Diagnosis. --- Malalties dels pulmons --- Patologia --- Radiologia --- Broncoscòpia --- Endoscòpia --- Física radiològica --- Física --- Radiografia --- Radiació --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic --- Malalties pulmonars --- Pneumopaties --- Bronquitis --- Displàsia broncopulmonar --- Fibrosi pulmonar --- Fibrosi quística --- Insuficiència respiratòria --- Legionel·losi --- Malalties pulmonars obstructives cròniques --- Pneumònia --- Pneumotòrax --- Malalties del pulmó
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