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Dendrimers. --- Pharmaceutical chemistry. --- Dendrimers --- Nanomedicine --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Dendritic compounds --- Macromolecules --- Dendrimer --- Dendritic Compounds --- Dendritic Polymers --- Dendrons --- Compound, Dendritic --- Dendritic Compound --- Dendritic Polymer --- Polymer, Dendritic --- Polymers, Dendritic

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Significant research efforts are currently being undertaken in the field of natural and synthetic polymers for a range of biomedical applications. (Co)polymer molecular structure, topology, self-assemblies, biodegradation, and hydrophobicity are of biomaterial importance for intrinsically biocompatible polymer systems. This book is comprised of nine chapters, published previously as original research contributions of the Special Issue focused on advances in polymeric materials for biomedical applications. The authors of these contributions are predominantly from central European countries, Italy and the United Kingdom. The content of this book will be of interest to scientists, scholars and students working in this area of knowledge, reflecting the progress in the development of advanced natural and synthetic polymer biomaterials.

Technology: general issues --- fish gelatin --- citric acid --- electrospinning --- pH --- thermal treatment --- gelatin structure --- crosslinking degree --- dendrimer --- metallodendrimer --- acridine --- antimicrobial activity --- antibacterial cotton --- polystyrene --- nylon 6 --- electrospun fibers --- composite mesh --- proliferation --- roughness --- Ti6Al4V --- polydopamine --- antimicrobial peptides --- cathelicidin --- KR-12 --- polyhydroxyalkanoates --- oligo(3-hydroxy-3-(4-methoxybenzoyloxymethyl)propionate) --- bioactive (co)oligoesters --- p-anisic acid derivatives --- hydrolytic degradation --- cosmetic delivery system --- ESI-MS --- multistage mass spectrometry --- whey protein isolate --- hydrogel --- tannic acid --- anticancer scaffold --- 3D printing --- fused deposition modelling (FDM) --- computer aided design (CAD) --- erosion test --- dissolution study --- dynamic light scattering (DLS) --- poly(2-isopropenyl-2-oxazoline) --- immunomodulation --- cytokines --- RAW 264.7 --- phagocytosis --- cell internalization --- antifungal --- thymoquinone --- ocimene --- miramistin amphotericin b --- bacterial cellulose --- wound dressing

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The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation

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This book presents recent advances in computational methods for polymers. It covers multiscale modeling of polymers, polymerization reactions, and polymerization processes as well as control, monitoring, and estimation methods applied to polymerization processes. It presents theoretical insights gained from multiscale modeling validated with exprimental measurements. The book consolidates new computational tools and methods developed by academic researchers in this area and presents them systematically. The book is useful for graduate students, researchers, and process engineers and managers.

History of engineering & technology --- rapid tooling --- additive manufacturing --- failure modes --- injection molding --- modeling --- olefin --- gas phase --- kinetics --- hyperbranched --- Monte Carlo simulation --- radius of gyration --- span length --- continuous stirred-tank reactor --- data-driven parameter estimation --- retrospective cost model refinement algorithm --- global sensitivity analysis --- polyolefin synthesis --- olefin copolymerization --- reactivity ratios --- electronic effects --- salan catalysts --- post-metallocene --- DFT --- insertion kinetics --- olefin capture --- PolyEThyleneAmidoAmine (PETAA) dendrimer --- molecular topological indices --- Eccentric connectivity index --- copolymerization --- design of experiments --- reactivity ratio estimation --- terpolymerization --- PLP-SEC --- n-butyl acrylate --- degree of branching --- nanostar dendrimer --- irregularity measure --- complexity of structure --- NS1[p] --- NS2[p] --- NS3[p] --- subspace identification --- polymer processing --- model predictive control --- rotational molding --- batch process modeling and control --- method of moments --- free-radical polymerization --- methyl acrylate --- thermal polymerization --- high-temperature polymerization --- molecular graph --- irregularity indices --- dendrimers --- density functional theory --- inhibitors --- phenolic --- stable nitroxide radicals --- styrene --- polymerization --- RAFT polymerization --- multi-rate observer --- nonlinear sampled-data system --- measurements with delay --- parameter fitting --- droplet impact --- viscoelasticity --- volume of fluid method --- process intensification --- operability --- modularity --- process modeling and simulation --- n/a

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This book “Oxidative Stress Modulators and Functional Foods” is focused on the antioxidant role of natural products, involving their ability to modulate oxidative stress and/or reverse disease studied both in vitro and in animal models. Additionally, the molecular mechanisms of these actions and the modulation of signalling pathways related to inflammation, apoptosis, and survival response in the redox system by natural products are included.

Medicine --- Pharmaceutical industries --- high sugar-fat diet --- obesity --- β-adrenergic system --- cardiac dysfunction --- lycopene --- tomato-oleoresin --- coumarin --- pteryxin --- HO-1 --- Nrf2 --- oxidative stress --- Peucedanum japonicum Thunb --- RAW264.7 cells --- polysaccharide --- jujube pomace --- structural analysis --- antioxidant activity --- epigallocatechin-gallate --- liposomes --- diabetes mellitus --- antioxidant --- dendrimer --- electronic effect --- hydrogen atom transfer (HAT) --- single electron transfer-proton transfer (SET-PT) --- sequential proton loss electron transfer (SPLET) --- DPPH --- ultraviolet B --- gradient ethanol precipitation --- fucoidan --- HaCaT keratinocyte --- heme oxygenase-1 --- nutricosmetic --- folic acid --- nitric oxide --- neural tube defects --- NOR3 --- ESR --- LC/MS --- Benzo[a]pyrene --- myricetin --- BPDE-DNA adduct --- phase detoxifying enzyme --- Quamoclit angulata --- type 2 diabetes --- kidney damage --- inflammation --- apoptosis --- fibrosis --- Sargassum horneri --- (–)-loliolide --- fine dust --- HaCaT --- bilberry --- lingonberry --- polyphenols --- antioxidant compounds --- antimicrobial activity --- antimutagenicity --- altitude variations --- mitochondria --- neurodegeneration --- nutrient --- QM-ORSA --- antioxidative mechanisms --- reaction rate constants --- physiological conditions --- zebrafish embryo --- in vivo model --- antioxidant effect --- cudratrixanthone O --- reactive oxygen species --- nuclear transcription factor erythroid-2-like factor 2 --- hemeoxygenase-1 --- n/a --- (-)-loliolide