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Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy

Diabetic nephropathies. --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Kidneys --- Complications --- Diseases --- Renal medicine & nephrology

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

chronic kidney diseases --- Diabetic kidney disease --- Genome-Wide Association Study --- Kidney Transplantation --- Next-generation sequencing --- precision medicine

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Medical genetics --- chronic kidney diseases --- Diabetic kidney disease --- Genome-Wide Association Study --- Kidney Transplantation --- Next-generation sequencing --- precision medicine

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Although diabetic kidney disease is the most prevalent cause of end-stage renal disease and the disease most often leading to chronic renal replacement therapy and kidney transplantation, there has been, in recent years, a steady increase in basic and clinical knowledge of the problem. In The Diabetic Kidney, a stellar group of international researchers and clinicians joins forces to independently survey recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. Drawing on many years of experience, the authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Not always in total agreement, their views reflect the present state of knowledge and its uncertainties, and offer a composite of different authoritative views on the causes of diabetic kidney disease. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and comprehensive descriptions of the most up-to-date views on the diagnosis and treatment of the disease. State of the art and illuminating, The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Diabetic nephropathies. --- Diabetes. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Kidneys --- Diseases --- Complications --- Endocrinology. --- Internal medicine --- Hormones --- Endocrinology .

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This book provides a toolkit of novel research approaches for investigators to study diabetic nephropathy, including critical experimental models from the fly to the fish, cells in culture, and in vivo mammalian approaches. The collection also explores powerful techniques to image the kidney, such as traditional histological techniques as well as electron, confocal, and two-photon microscopy, pathophysiology of the diabetic kidney, and gene editing and regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Nephropathy: Methods and Protocols seeks to foster new research directions and inspire ideas to enhance our understanding of diabetic nephropathy and to develop treatments for this condition.

Diabetic nephropathies. --- Diabetic kidney disease --- Diabetic kidney failure --- Diabetic nephropathy --- Diabetic renal failure --- Diabetes --- Kidneys --- Complications --- Diseases --- Nefropaties diabètiques --- Complicacions de la diabetis --- Malalties del ronyó --- Medicine—Research. --- Biology—Research. --- Nephrology. --- Diseases. --- Biomedical Research. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Internal medicine