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Drug monitoring.

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The textbook provides an overview of the main techniques applied in pharmaceutical industry, with the focus on solid-state analysis. It discusses spectral methods, thermal analysis, and dissolution testing, explains the theoretical background for each method and shows practical examples from a real-life drug-design and quality control applications. The textbook is thus intended for both pharmacy students and early career professionals.

Drug monitoring.

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Drug monitoring.

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Pharmacokinetics. --- Drug Monitoring. --- Pharmacology. --- Drug monitoring. --- Pharmacocinétique --- Pharmacovigilance --- Pharmacokinetics --- Drug monitoring --- Drug Monitoring --- Pharmacology --- Pharmacocinétique

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Recent advances in understanding the link between metabolic mutations and cancer have been able to demonstrate the importance of the serine synthesis pathway (SSP). Through its role in processes balancing cell metabolism like the folate cycle, histone methylation, and the synthesis of antioxidants, the SSP can greatly modulate cancer cell survival and proliferation. Of all the enzymes of the SSP, the most reported in cancer metabolism is PHGDH. Interestingly, pharmacological inhibition or gene silencing of this enzyme. At the CMFA lab, a number of compounds with enzymatic and in vitro activity have already bee, developed. During this project, a series of twelve thioamides were synthesized using the Wilgerodt-Kindler and thioamidation reactions. Their enzymatic activity was evaluated on PHGDH and a first cellular evaluation was carried out on cell lines BT-20, MDA-MB231 and BJ-5TA. Three compounds (LAV-6, LAV-7 AND LAV-9) showed micromolar inhibition of PHGHDH and the estimation of their ligand-lipophilicity efficiency (LLE) was able to show that they are promising for further development. Moreover, this project has been able to bring some structure-activity relationship (SAR) hypothesis to light. In conclusion, this study has identified a number of new pharmacological tools inhibiting PHGDH as a starting point to study the structure-activity relationship (SAR) of this enzyme. Les avancées récentes dans la compréhension du lien entre les modifications métaboliques et le cancer, ont permis de mettre en évidence l’importance de la voie de synthèse de la sérine. En effet, de par son rôle crucial dans un grand nombre de voies telles que le cycle du folate, l’équilibre oxydo-réducteur ou encore la méthylation cellulaire, ce processus module la croissance et la prolifération de nombreuses lignées néoplasiques. Parmi les enzymes de cette voie, la plus décrite dans la littérature est la PHGDH. Plusieurs équipes de recherches ont déjà montré que son inhibition pharmacologique ou génétique diminue la prolifération et la survie des cellules cancéreuses in vitro et in vivo. De plus, ce travail a amené des hypothèses quant aux relations structure-activité qui existent au sein de ces inhibiteurs. En conclusion, cette recherche a identifié plusieurs nouveaux outils pharmacologiques inhibant la PHGDH qui permettent de mieux étudier les relations structure-activité existant avec cette enzyme.

Phosphoglycerate Dehydrogenase --- Drug Monitoring