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New technology for analyzing complex genomes is an important area of modern molecular biosciences. This book focuses on a recently developed genome scanning method, termed two-dimensional 2-D DNA typing, which is based on a combination of two independent electrophoretic separation principles. When separation according to size is coupled to separation according to base-pair composition, complex genomes can be resolved in a number of DNA fragments. These fragments or subsets can be visualized, for example, by hybridization analysis with specific probes. Genome scanning by 2-D DNA typing finds applications in many areas, such as linkage and association studies for identifying genetic traits in humans, animals and plants, studies on genetic instabilities in cancers, classification studies in bacteria and other lower organisms, studies on human mutation rates, and the identification of mutations in large genes.
DNA --- Electrophoresis, Gel, Two-Dimensional --- Two-dimensional electrophoresis --- ADN --- Electrophorèse bidimensionnelle --- analysis --- methods --- Analysis --- Analyse --- Two-dimensional electrophoresis. --- Electrophoresis, gel, two-dimensional --- Dna --- Analysis. --- Methods. --- analysis. --- methods.
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DNA Mutational Analysis --- Electrophoresis, Gel, Two-Dimensional --- Genetic Testing --- methods --- methods --- methods
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Biological techniques --- Fysicochemical analysis in organic chemistry --- Analytical biochemistry --- Electrophoresis, Agar Gel --- Electrophoresis, Gel, Two-Dimensional --- Immunoblotting --- Isoelectric Focusing --- Proteins --- Proteines --- Protéines --- methods --- laboratory manuals --- analysis --- isolation & purification --- Purification --- Research --- Methodology --- Recherche --- Méthodologie --- 577.112.4 --- -Proteins --- -#WSCH:WBIO --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- methods. --- analysis. --- isolation & purification. --- Chemical reactions of the proteins. Determination of terminal and functional groups. Chemical modification of proteins --- -Methodology --- Purification. --- Methodology. --- laboratory manuals. --- 577.112.4 Chemical reactions of the proteins. Determination of terminal and functional groups. Chemical modification of proteins --- Protéines --- Méthodologie --- #WSCH:WBIO --- Research&delete&
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Proteomics is a multifaceted, interdisciplinary field which studies the complexity and dynamics of proteins in biological systems. It combines powerful separation and analytical technology with advanced informatics to understand the function of proteins in the cell and in the body. This book provides a clear conceptual description of each facet of proteomics, describes recent advances in technology and thinking in each area, and provides details of how these have been applied to a variety of biological problems. It is written by expert practitioners in the field, from industry, research institutions, and the clinic. It provides junior and experienced researchers with an invaluable proteomic reference, and gives fascinating glimpses of the future of this dynamic field.
Post-translational modification. --- Proteins. --- Proteomics. --- Proteomics --- Proteins --- Post-translational modification --- Genomics --- Databases, Genetic --- Electrophoresis, Polyacrylamide Gel --- Biochemistry --- Electrophoresis --- Electrochemical Techniques --- Databases, Factual --- Computational Biology --- Chemistry --- Biological Science Disciplines --- Genetics --- Chemistry Techniques, Analytical --- Biology --- Investigative Techniques --- Natural Science Disciplines --- Databases as Topic --- Information Storage and Retrieval --- Disciplines and Occupations --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Information Systems --- Information Science --- Medical Informatics Applications --- Medical Informatics --- Electrophoresis, Gel, Two-Dimensional --- Databases, Protein --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Animal Biochemistry --- Databases --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Proteids --- Life sciences. --- Molecular biology. --- Biochemistry. --- Bioinformatics. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Molecular Medicine. --- Molecular biology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Biosciences --- Sciences, Life --- Science --- Data processing --- Composition --- Genetic translation --- Polypeptides --- Synthesis --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Health Workforce --- Medicine --- Protein Biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
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