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Natural products. --- Enzyme inhibitors. --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Products, Natural --- Raw materials --- Antagonists --- Inhibitors

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Bio-Inorganic compounds are successfully applied as therapeutic agents since decades. Thus, scientist designed new metal complexes bearing biomolecules as ligands, investigating their potential as bioactive and therapeutic agents. This book presents a comprehensive overview on materials design, substance classes and their characterization. This book is compiled for scientists interested in medical application of bioinspired materials.

Bioinorganic chemistry. --- Enzyme inhibitors. --- Metalloproteins. --- Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Organometallic compounds --- Proteins --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Bio-inorganic chemistry --- Biological inorganic chemistry --- Inorganic biochemistry --- Biochemistry --- Chemistry, Inorganic --- Antagonists --- Inhibitors

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Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.

Cancer --- Enzyme inhibitors --- Carcinogenesis --- Treatment. --- Therapeutic use. --- Molecular aspects. --- Genetic aspects. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Molecular carcinogenesis --- Pathology, Molecular --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Cancer therapy --- Cancer treatment --- Pathogenesis --- Antagonists --- Inhibitors --- Therapy --- Oncology. --- Oncology  . --- Chemistry. --- Cancer Research. --- Chemistry/Food Science, general. --- Physical sciences --- Tumors --- Cancer research. --- Cancer research

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Cancer --- Enzyme inhibitors. --- Cyclin-dependent kinases --- Neoplasms --- Cyclin-Dependent Kinases --- Chemotherapy. --- Inhibitors. --- antagonists & inhibitors --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- CDK proteins --- Cyclin-dependent protein kinases --- Protein kinases --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Antineoplastic agents --- Antagonists --- Inhibitors --- Treatment

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This book presents authoritative accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using themany sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors, emphasizing the factors which affect their usefulness in the clinical context : bioavailability, pharmacokinetics andside-effects.

Enzyme inhibitors --- Enzyme Inhibitors. --- Structure-activity relationships. --- Enzyme Inhibitors --- Inhibitors, Enzyme --- Sulfhydryl Reagents --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- antagonists & inhibitors --- Chemistry, Pharmaceutical --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Metabolic inhibitors --- Chemical inhibitors --- Structure-activity relationships --- Therapeutic use&delete& --- Testing --- Antagonists --- Inhibitors --- Enzymology --- Pharmacology. Therapy --- Chemistry, Pharmaceutical. --- Therapeutic use --- Testing. --- Antienzymes --- Chimie pharmaceutique. --- Médicaments. --- Pharmaceutical Preparations. --- Emploi en thérapeutique --- Essais. --- Relations structure-activité. --- Enzyme Inhibitor --- Inhibitor, Enzyme --- Pharmaceutical Preparations