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Immunology. Immunopathology --- General embryology. Developmental biology --- Aging --- Vieillissement --- immunology --- Immunological aspects --- Periodicals. --- Immunologie --- Périodiques --- immunology. --- Immunological aspects. --- Age --- Ageing --- Senescence --- Physiological effect --- ageing --- immunology --- gerontology --- geriatrics --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Health and social care --- Immunology. --- Gerontology. --- Geriatrics --- Allergy --- allergieën --- gerontologie --- Envelliment. --- Immunologia. --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Senectut --- Biologia del desenvolupament --- Persones de mitjana edat --- Persones grans --- Gerontologia --- Longevitat --- Envelliment cerebral --- Factors d'edat en les malalties

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This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

Medicine. --- Cell biology. --- Internal medicine. --- Biochemistry. --- Physiology. --- Biomedicine, general. --- Cell Biology. --- Internal Medicine. --- Biochemistry, general. --- Animal physiology --- Animals --- Biology --- Anatomy --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Medicine, Internal --- Medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Health Workforce --- Physiology --- Composition --- Ubiquinones --- Physiological effect. --- Coenzyme Q --- Coenzyme Q10 --- Dimethoxymethylbenzoquinone --- Coenzymes --- Isopentenoids --- Quinone --- Envelliment --- Coenzims --- Citologia --- Biologia cel·lular --- Biologia --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules --- Cèl·lules animals --- Ultraestructura (Biologia) --- Enzims --- NAD (Coenzim) --- Senectut --- Biologia del desenvolupament --- Persones de mitjana edat --- Persones grans --- Gerontologia --- Longevitat --- Envelliment cerebral --- Factors d'edat en les malalties

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The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Aging --- Gerontology. --- Molecular aspects. --- Social sciences --- Geriatrics --- Older people --- Molecular aging --- Molecular biology --- Biomedical engineering. --- Geriatrics. --- Molecular biology. --- Human genetics. --- Metabolism. --- Regenerative medicine. --- Tissue engineering. --- Biomedical Engineering/Biotechnology. --- Geriatrics/Gerontology. --- Molecular Medicine. --- Human Genetics. --- Metabolomics. --- Regenerative Medicine/Tissue Engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Gerontology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology --- Diseases --- Health and hygiene --- Biologia humana --- Envelliment --- Medicina preventiva --- Prevenció de les malalties --- Profilaxi --- Programes de prevenció --- Higiene --- Veterinària preventiva --- Avaluació del risc per la salut --- Cribratge --- Medicina social --- Salut pública --- Senectut --- Biologia del desenvolupament --- Persones de mitjana edat --- Persones grans --- Gerontologia --- Longevitat --- Envelliment cerebral --- Factors d'edat en les malalties --- Biologia --- Home --- Anatomia humana --- Ecologia humana --- Fisiologia humana --- Embriologia humana --- Genètica humana --- Medicina --- Psicologia --- Antropologia física