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Boomvormige cellen --- Cellen [Boomvormige ] --- Cellules dendritiques --- Dendritic cells --- Follicular dendritic cells --- Interdigitating cells --- Dendritic Cells --- Antibodies --- Antigens --- immunology --- immunology. --- Immunology. --- Immune system --- Physiology

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It is now apparent that dendritic cells not only play important roles in the body's immune system through their complex interactions with T cells, B cells, and other cell types, but also possess distinct functional attributes that enable them to assume different roles in that system. In Dendritic Cell Protocols, Stephen P. Robinson, MD, PhD, and Andrew Stagg, PhD, have brought together a wide range of time-proven methods for studying these so-called "veiled" cells. Many of these readily reproducible techniques deal with the problem of obtaining sufficient dendritic cells for analysis, whether by isolation from a wide variety of tissues or from various progenitor cell populations. Other methods describe in step-by-step fashion the techniques commonly used for analyzing aspects of dendritic cells, ranging from cell migration to antigen uptake and T cell stimulation. Variant methods that have been successful in other laboratories have been included to expand experimental possibilities. In addition, a few techniques explore the practical challenges involved in using dendritic cells in a clinical setting to develop novel immunotherapeutics. State-of-the-art and highly practical, Dendritic Cell Protocols provides both experienced and novice investigators with powerful tools to illuminate the complex biology of these foundation cells-cells that shape the evolution of acquired immune responses, play important roles in innate immunity, and promise the development of powerful new immunotherapeutics.

Dendritic Cells --- Dendritic cells --- Cytology. --- Physiology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Follicular dendritic cells --- Interdigitating cells --- Antigen presenting cells --- Lymphoid tissue --- Immunology. --- Immunobiology --- Life sciences --- Serology

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In this book, the authors discuss the biophysical characteristics of Dendritic cells (DCs) at various differentiation stages and in tumor microenvironments in detail. A type of Chinese traditional herb, which can improve the biophysical and microrheological properties of DCs, is also introduced. DCs are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The biophysical and microrheological characteristics of DCs are important for their motility and normal immune function. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown. This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency of anti-tumor therapy based on DCs.     .

Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Dendritic cells. --- Dendritic cells --- Follicular dendritic cells --- Interdigitating cells --- Medicine. --- Cancer research. --- Immunology. --- Pharmacology. --- Biomedicine. --- Biological and Medical Physics, Biophysics. --- Cancer Research. --- Pharmacology/Toxicology. --- Antigen presenting cells --- Lymphoid tissue --- Oncology. --- Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Biophysics. --- Biological physics. --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Biological physics --- Physics --- Physiological effect

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Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ­ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".

B cells --- Macrophages --- Dendritic cells --- Natural immunity. --- Cellular immunity. --- Receptors. --- Cell-mediated immunity --- Cellular immunology --- Clonal selection theory --- Immune response --- Immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Follicular dendritic cells --- Interdigitating cells --- Antigen presenting cells --- Lymphoid tissue --- Histiocytes --- Mononuclear phagocytes --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Lymphocytes --- Cytology. --- Immunology. --- Cell Biology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.

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Significant features of cancer are suppression and redirection of the immune response, which allow for tumor development and growth in the previously immune competent host. Central to development of immune responses are dendritic cells, and unsurprisingly these cells are strongly impacted by tumors and factors derived from them, as well as by other conditions associated with tumor progression or cancer treatments. Further, as some of the frontline strategies for treatment of cancer involve immunotherapy with ex vivo cultured or in vivo modulated dendritic cells, it becomes imperative to understand how dendritic cells interact with and are affected by the tumor microenvironment. "Dendritic Cells in Cancer," edited by Michael R. Shurin and Russell D. Salter, presents thorough analyses of the complex biology of the tumor-dendritic cell relationship, and offers insights into how cancer treatments may benefit from furthering our understanding in this area.

Cancer --Immunotherapy. --- Dendritic cells. --- Dendritic cells --- Cancer --- Immunomodulation --- Antigen-Presenting Cells --- Epithelial Cells --- Medicine --- Diseases --- Investigative Techniques --- Mononuclear Phagocyte System --- Immune System --- Cells --- Health Occupations --- Biological Therapy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Hemic and Immune Systems --- Anatomy --- Therapeutics --- Dendritic Cells --- Neoplasms --- Immunotherapy --- Methods --- Pathology --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Oncology --- Immunotherapy. --- Follicular dendritic cells --- Interdigitating cells --- Medicine. --- Cancer research. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pharmacology/Toxicology. --- Antigen presenting cells --- Lymphoid tissue --- Immunological aspects --- Treatment --- Oncology. --- Cytology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Cytologists --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect