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Gestational diabetes mellitus (GDM) is one of the most common adverse medical conditions that occurs during pregnancy, and its prevalence is rising as part of a diabetes pandemic. Nutrition plays a key role in GDM, whether (1) as part of an ‘unhealthy’ diet, which contributes to its cause, or (2) as part of changes in dietary intake, which act as the frontline treatment for GDM (sometimes supplemented with exercise and pharmacological intervention). Dietary changes, therefore, can alter the risk of developing GDM in the first place, and once GDM has emerged during pregnancy, dietary changes can mitigate the risk of developing GDM-related complications, such as macrosomia, respiratory distress, hypoglycemia and jaundice in the neonate, pre eclampsia, increased need for caesarean section and placental abruption in the mother. In this Special Issue, we aim to highlight the role of nutrition in the aetiology of GDM, whether directly or indirectly through weight gain and obesity, and in its role as a GDM treatment to lower hyperglycemia and the risk of the aforementioned complications.

microbiome --- pregnancy --- obesity --- ketonuria --- Roseburia --- diet --- food frequency questionnaire --- glucose --- insulin secretion --- human milk --- breastfeeding --- gestational diabetes mellitus --- insulin-dependent diabetes mellitus --- preterm newborn --- gestational diabetes --- dietary patterns --- maternal nutrition --- dietary adaptations --- glycemic index --- postprandial glycemic response --- blood glucose prediction --- diabetes --- gestational weight gain --- macrosomia --- adiposity --- neonate --- exercise --- physical activity --- dietary carbohydrates --- diabetes-specific formula --- continuous glucose monitoring --- glycemic variability --- carbohydrate distribution --- mean amplitude of glucose --- breakfast diet --- platelet-activating factor --- tumor necrosis factor α --- methylglyoxal --- glycated albumin --- endocrine disruptors --- endocrine-disrupting chemicals --- bisphenol A --- BPA --- phthalates --- pregnancy outcomes --- eating speed --- cohort study --- prevention --- nutrition --- polyphenolic compounds --- bioactive compounds --- leptin resistance --- inflammation --- Mediterranean diet --- n/a

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Iodine, a key component of thyroid hormones, is considered an essential micronutrient for proper health at all life stages. Indeed, an inadequate dietary intake of iodine is responsible for several functional and developmental abnormalities. The most serious consequences of iodine deficiency include hypothyroidism, early abortion, low birth weight, preterm delivery, neurocognitive impairment, and mental retardation. On the other hand, the consequences of mild-to-moderate iodine deficiency, such as goiter, are less well understood but represent an important priority for research and public health practice. Over the last several decades, many countries across the globe have introduced mandatory salt iodization programs, which have dramatically reduced the number of iodine-deficient countries. However, despite substantial progress worldwide, mild-to-moderate deficiency is still prevalent even in many developed countries. Thus, the ongoing monitoring of the population iodine status remains crucially important, and attention may need to be paid to vulnerable life stage groups.

Humanities --- Social interaction --- iodine deficiency --- schoolchildren --- pregnancy --- iodine prophylaxis --- iodine deficiency disorders --- goiter --- hypothyroidism --- nutraceuticals --- thyroid function --- dietary supplements --- urinary iodine concentration --- iodine --- thyroid hormones --- thyroglobulin --- thyroid stimulating hormone --- preterm birth --- small for gestational age --- iodine nutrition status --- thyroid disease --- thyrotropin --- urine iodine --- epidemiologic studies --- Korean --- Republic of Moldova --- salt --- sodium --- potassium --- population --- Iodine Status --- Food Frequency Questionnaire --- iodized salt --- iodine intake --- dairy intake --- adults --- iodine status --- human milk --- lactation --- infant growth --- iodine schoolchildren --- goitre --- iodised salt --- water iodine --- iodine pregnant women --- cadmium --- myo-inositol --- seleno-L-methionine --- thyroid --- MCP-1 --- CXCL10 --- carnitine --- flavonoids --- melatonin --- omega-3 --- resveratrol --- selenium --- vitamins --- zinc --- perchlorate --- Natrium/Iodide symporter --- endocrine disruptors --- review --- drinking and Food --- Hypothyroidism --- iodine deficiency --- schoolchildren --- pregnancy --- iodine prophylaxis --- iodine deficiency disorders --- goiter --- hypothyroidism --- nutraceuticals --- thyroid function --- dietary supplements --- urinary iodine concentration --- iodine --- thyroid hormones --- thyroglobulin --- thyroid stimulating hormone --- preterm birth --- small for gestational age --- iodine nutrition status --- thyroid disease --- thyrotropin --- urine iodine --- epidemiologic studies --- Korean --- Republic of Moldova --- salt --- sodium --- potassium --- population --- Iodine Status --- Food Frequency Questionnaire --- iodized salt --- iodine intake --- dairy intake --- adults --- iodine status --- human milk --- lactation --- infant growth --- iodine schoolchildren --- goitre --- iodised salt --- water iodine --- iodine pregnant women --- cadmium --- myo-inositol --- seleno-L-methionine --- thyroid --- MCP-1 --- CXCL10 --- carnitine --- flavonoids --- melatonin --- omega-3 --- resveratrol --- selenium --- vitamins --- zinc --- perchlorate --- Natrium/Iodide symporter --- endocrine disruptors --- review --- drinking and Food --- Hypothyroidism

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Phenylketonuria (PKU) is an established inherited amino acid disorder with a very traditional dietary therapy, but there is still more to learn and verify about its nutritional composition, application and overall effectiveness. Although in the 1950s, the first patient successfully treated with diet therapy patently established the role of a low phenylalanine protein substitute, in present times, it is still necessary to characterise the most effective source of artificial protein; defining its optimal amino acid profile; and identifying nutrient modulation that will improve the functionality of protein substitutes. It is also important to understand the impact of a life-long synthetic diet on gut microbiota, metabolomics and inflammatory status. In early-treated patients with PKU, it is unclear if co-morbidities such as overweight, obesity, hypertension and diabetes are higher than in the general population and if these are associated with increased cardiovascular risk. It is also uncertain if overweight and obesity in PKU is related to early dietary practices, the nutritional composition of protein substitutes and special low-protein foods, impact of the dietary treatment on satiety, disordered eating patterns, non-adherence with the low phenylalanine diet and poor metabolic control, or if this is even a consequence of the disorder. In a generation of ageing patients, the impact of intermittent and suboptimal dietary adherence on nutritional status deserves systematic study.

Research & information: general --- Biology, life sciences --- Food & society --- phenylketonuria --- special low protein foods --- nutritional composition --- UK --- macronutrients --- phenylketonuria (PKU) --- consensus --- Delphi method --- food labelling --- phenylalanine --- Phe --- protein --- exchanges --- PKU --- glycomacropeptide --- amino acid --- absorption --- diet therapy --- protein substitute --- gastrointestinal symptoms --- prolonged release --- satiety --- macronutrient intake --- protein content --- free from --- gluten free --- aspartame --- sugar tax --- phenylalanine hydroxylase deficiency --- hyperphenylalaninemia --- medical formula --- amino acid mixture --- tetrahydrobiopterin --- sapropterin --- BH4 --- body composition --- bone mineral density --- bone turnover markers --- osteoporosis --- blood biochemistry --- casein glycomacropeptide --- amino acid protein substitute --- low-protein diet --- newborn screening --- metabolic control --- guidelines --- nitrogen balance --- amino acid catabolism --- blood urea nitrogen --- body mass index --- obesity --- overweight --- phenylalanine restriction --- phenylalanine-restricted diet --- food --- school --- IHCP --- parent/caregiver experiences --- England --- prescribing patterns --- costs --- adult phenylketonuria --- standard operating procedure --- inherited metabolic disorders --- dietary management --- eating out --- low protein food --- restaurants --- amino acids --- adherence --- epigenetics --- health --- preconception --- women --- dietary patterns --- food frequency questionnaire --- validation --- reproducibility

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Iodine, a key component of thyroid hormones, is considered an essential micronutrient for proper health at all life stages. Indeed, an inadequate dietary intake of iodine is responsible for several functional and developmental abnormalities. The most serious consequences of iodine deficiency include hypothyroidism, early abortion, low birth weight, preterm delivery, neurocognitive impairment, and mental retardation. On the other hand, the consequences of mild-to-moderate iodine deficiency, such as goiter, are less well understood but represent an important priority for research and public health practice. Over the last several decades, many countries across the globe have introduced mandatory salt iodization programs, which have dramatically reduced the number of iodine-deficient countries. However, despite substantial progress worldwide, mild-to-moderate deficiency is still prevalent even in many developed countries. Thus, the ongoing monitoring of the population iodine status remains crucially important, and attention may need to be paid to vulnerable life stage groups.

Humanities --- Social interaction --- iodine deficiency --- schoolchildren --- pregnancy --- iodine prophylaxis --- iodine deficiency disorders --- goiter --- hypothyroidism --- nutraceuticals --- thyroid function --- dietary supplements --- urinary iodine concentration --- iodine --- thyroid hormones --- thyroglobulin --- thyroid stimulating hormone --- preterm birth --- small for gestational age --- iodine nutrition status --- thyroid disease --- thyrotropin --- urine iodine --- epidemiologic studies --- Korean --- Republic of Moldova --- salt --- sodium --- potassium --- population --- Iodine Status --- Food Frequency Questionnaire --- iodized salt --- iodine intake --- dairy intake --- adults --- iodine status --- human milk --- lactation --- infant growth --- iodine schoolchildren --- goitre --- iodised salt --- water iodine --- iodine pregnant women --- cadmium --- myo-inositol --- seleno-L-methionine --- thyroid --- MCP-1 --- CXCL10 --- carnitine --- flavonoids --- melatonin --- omega-3 --- resveratrol --- selenium --- vitamins --- zinc --- n/a --- perchlorate --- Natrium/Iodide symporter --- endocrine disruptors --- review --- drinking and Food --- Hypothyroidism

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Over the last 100 years, the numerous advances in science, the improved sanitary conditions and a decline in poverty have led to an increase in life expectancy. As a result, in the coming years, the number of over-65s will triple, and the over-80s will be the fastest growing portion of the population.However, an increased lifespan is associated with an increase in chronic diseases, such as cardiovascular disease, diabetes, cancer, sarcopenia, and degenerative disorders. Therefore, ideally, increased lifespan should be associated to a better healthspan, which is the period one individual is living in good health.Based on evidence that aging is a multifaceted phenomenon, resulting from one or more failures at the molecular, cellular, physiologic, and functional levels, age-related diseases are difficult therapeutic targets.Data on the correlation between the quality of one’s diet and life expectancy, and the application of calorie restriction regimens, or of micronutrients, antioxidants and functional foods in the diet make nutrition, together with exercise, a natural weapon to combat age-related diseases and improve healthspan.

Research & information: general --- Biology, life sciences --- Food & society --- community-dwelling --- elderly --- exercise --- frailty --- intervention --- multi-component --- nutrition education --- randomized controlled trial --- hyperglycemia --- anthocyanins --- endothelial dysfunction --- vasodilation --- energy intake --- memory impairment --- carbohydrates --- sugar --- older adults --- sarcopenia --- muscle mass --- muscle strength --- nutrition --- food frequency questionnaire --- dietary patterns --- reduced rank regression --- community-dwelling older people --- Mediterranean diet --- frailty index --- trajectory --- performance --- nutritional status --- vitamin D --- protein --- vitamin E --- tocotrienol --- metabolites --- obesity --- mice --- inflammation --- diet --- food consumption --- cognition --- cognitive domains --- MCI subtypes --- China --- telomere --- carbohydrate --- NHANES --- antioxidant --- legume --- potato --- seafood --- elderly people --- health --- non-communicable diseases --- malnutrition --- Mexico --- MNA --- MHAS --- healthy aging --- dietary diversity --- physical functional limitation --- comorbidity --- psychological stress --- food restriction --- gut hormones --- hypothalamic neuropeptides and obesity --- aging --- life-span --- health-span --- calorie restriction --- calorie restriction mimetic --- resveratrol --- experimental models --- inflammaging --- probiotics --- healthy older subjects --- dietary pattern --- food variety score --- preterm --- breast milk --- fortification --- neurodevelopment --- community-dwelling --- elderly --- exercise --- frailty --- intervention --- multi-component --- nutrition education --- randomized controlled trial --- hyperglycemia --- anthocyanins --- endothelial dysfunction --- vasodilation --- energy intake --- memory impairment --- carbohydrates --- sugar --- older adults --- sarcopenia --- muscle mass --- muscle strength --- nutrition --- food frequency questionnaire --- dietary patterns --- reduced rank regression --- community-dwelling older people --- Mediterranean diet --- frailty index --- trajectory --- performance --- nutritional status --- vitamin D --- protein --- vitamin E --- tocotrienol --- metabolites --- obesity --- mice --- inflammation --- diet --- food consumption --- cognition --- cognitive domains --- MCI subtypes --- China --- telomere --- carbohydrate --- NHANES --- antioxidant --- legume --- potato --- seafood --- elderly people --- health --- non-communicable diseases --- malnutrition --- Mexico --- MNA --- MHAS --- healthy aging --- dietary diversity --- physical functional limitation --- comorbidity --- psychological stress --- food restriction --- gut hormones --- hypothalamic neuropeptides and obesity --- aging --- life-span --- health-span --- calorie restriction --- calorie restriction mimetic --- resveratrol --- experimental models --- inflammaging --- probiotics --- healthy older subjects --- dietary pattern --- food variety score --- preterm --- breast milk --- fortification --- neurodevelopment