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Dietary Supplements. --- Drug Interactions. --- Food-drug interactions --- Herbal medicine --- Plants, medicinal --- Food-drug interactions --- Herbal medicine --- Plants, medicinal

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There are not studies about herb-drug interactions despite the widespread use of herbal medicines. There are several qualities of “natural” products which contain different amounts of herbal active constituents. There is no process for systematic evaluation of botanical supplement products for possible interactions with prescription medications. That’s why, the study of the interactions between these products and the drugs were difficult. In the literature, there are two types of interactions between plants and drugs which are described. On the one hand, pharmacodynamic interactions occur when the pharmacological action of the plant cause an increase or a decrease in the pharmacological action of the drug. On the other hand, pharmacokinetic interactions occur when vegetable component is responsible for the changes in absorption, metabolism or elimination of the drug.
Clinically important interactions appear to involve effects on drug metabolism via cytochromes P450 isonzymes. We will study clinically significant herb-drug predictions of interactions were confirmed in vivo whereas others weren’t. So, it is important to promote the notification of all suspect interactions in order to prevent side effects in a better way. Continued education if consumers and healthcare professionals about the potential herb-drug interactions is required to ensure further interactions that do not occur Les produits à base de plantes ne font pas l’objet d’études approfondies qui permettraient une connaissance des interactions avec les médicaments. Il existe plusieurs conditionnements de produits «naturels» à base de plantes avec des teneurs en substances actives différentes. Ces produits « naturels » ne subissent pas des contrôles de qualité aussi rigoureux que les médicaments. C’est pourquoi, l’étude des interactions entre ces produits et les médicaments a été difficile. Dans la littérature, il existe deux types d’interactions entre plantes et médicaments qui sont décrits. D’une part, les interactions d’ordre pharmacodynamique sont observées quand l’action pharmacologique de la plante a pour effet d’augmenter ou de diminuer l’action pharmacologique du médicament en agissant a niveau des récepteurs. D’autre part, les interactions d’ordre pharmacocinétique sont observées lorsqu’un constituant végétal est responsable des changements au niveau de l’absorption, du métabolisme ou de l’élimination du médicament. Les principales interactions pharmacocinétiques revêtant d’une importance clinique seront dues aux variations d’activités enzymatiques des CYP450 induites par la présence d’inducteur ou d’inhibiteur au sein de la plante. Ce travail a pour objet l’étude des interactions entre les produits à base de plantes non médicamenteux et les médicaments au niveau des CYP450. Nous verrons que certaines prédictions d’interactions ont été confirmées in vivo alors que d’autres pas. Il est donc important d’encourager le rapportage de tous les cas « suspects » d’interactions afin de mieux prévenir les effets secondaires. La vigilance s’impose surtout avec els médicaments à faible index thérapeutique. Lors de la délivrance de médicaments, le pharmacien jour un rôle essentiel dans le conseil et la prévention des interactions.

Drug Interactions --- Herb-Drug Interactions --- Cytochrome P-450 Enzyme System --- Food-Drug Interactions

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Food-Drug Interactions. --- Drug Interactions. --- Nutrition --- Diet Therapy. --- Metabolism --- Plants, Medicinal --- Drug-nutrient interactions. --- Interactions médicaments-aliments --- drug effects. --- metabolism.

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Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections, all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

Chemistry. --- Drug-nutrient interactions -- Handbooks, manuals, etc. --- Food-Drug Interactions -- Handbooks. --- Nutrition. --- Nutritional Physiological Phenomena -- Handbooks. --- Nutritional Physiological Phenomena. --- Toxicology. --- Drug-nutrient interactions --- Drug Interactions --- Physiological Phenomena --- Food-Drug Interactions --- Nutritional Physiological Phenomena --- Phenomena and Processes --- Pharmacological Processes --- Physiological Processes --- Pharmacological Phenomena --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Biophysics --- Pharmacology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Toxicology --- Health aspects --- Nutrition   . --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This book serves to highlight the pharmacokinetics/drug–drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.

Medicine --- Pharmaceutical industries --- tofacitinib --- dose-dependent pharmacokinetics --- hepatic and intestinal first-pass effect --- rats --- catalposide --- in vitro human metabolism --- UDP-glucuronosyltransferase --- sulfotransferase --- carboxylesterase --- celecoxib --- drug–drug interaction --- fluorescence --- HPLC --- metabolism --- repaglinide --- HSG4112 --- anti-obesity agent --- stereoselectivity --- pharmacokinetics --- compound K --- protopanaxadiol (PPD) --- biliary excretion --- intestinal metabolism --- Carthamus tinctorius extract --- notoginseng total saponins --- comparative pharmacokinetic study --- large volume direct injection --- compatibility mechanism --- mertansine --- human hepatocytes --- cytochrome P450 --- UDP-glucuronosyltransferases --- sodium-glucose cotransporter 2 (SGLT2) inhibitors --- DWP16001 --- kidney distribution --- inhibition mode --- diabetes --- transporter-enzyme interplay --- influx transporter --- efflux transporter --- physiologically based pharmacokinetic model --- cytochrome P450 enzymes --- tiropramide --- healthy Korean subjects --- modeling --- population pharmacokinetic --- quercetin --- breast cancer resistance protein --- inhibitor --- prazosin --- sulfasalazine --- kinetic analysis --- food–drug interactions --- Caco-2 --- EpiIntestinal --- first-pass --- P-gp --- BCRP --- drug transporter --- CYP3A4 --- oral availability --- automatization --- drug absorption --- drug dosing --- head-and-neck cancer --- real-time measurements --- taxanes --- tissue engineering --- UHPLC-MS/MS --- metformin --- verapamil --- drug interaction --- organic cation transporter 2 --- renal excretion --- acute renal failure --- gentamicin --- cisplatin --- hepatic CYP3A1(23) --- creatinine clearance --- renal clearance --- nonrenal clearance --- tofacitinib --- dose-dependent pharmacokinetics --- hepatic and intestinal first-pass effect --- rats --- catalposide --- in vitro human metabolism --- UDP-glucuronosyltransferase --- sulfotransferase --- carboxylesterase --- celecoxib --- drug–drug interaction --- fluorescence --- HPLC --- metabolism --- repaglinide --- HSG4112 --- anti-obesity agent --- stereoselectivity --- pharmacokinetics --- compound K --- protopanaxadiol (PPD) --- biliary excretion --- intestinal metabolism --- Carthamus tinctorius extract --- notoginseng total saponins --- comparative pharmacokinetic study --- large volume direct injection --- compatibility mechanism --- mertansine --- human hepatocytes --- cytochrome P450 --- UDP-glucuronosyltransferases --- sodium-glucose cotransporter 2 (SGLT2) inhibitors --- DWP16001 --- kidney distribution --- inhibition mode --- diabetes --- transporter-enzyme interplay --- influx transporter --- efflux transporter --- physiologically based pharmacokinetic model --- cytochrome P450 enzymes --- tiropramide --- healthy Korean subjects --- modeling --- population pharmacokinetic --- quercetin --- breast cancer resistance protein --- inhibitor --- prazosin --- sulfasalazine --- kinetic analysis --- food–drug interactions --- Caco-2 --- EpiIntestinal --- first-pass --- P-gp --- BCRP --- drug transporter --- CYP3A4 --- oral availability --- automatization --- drug absorption --- drug dosing --- head-and-neck cancer --- real-time measurements --- taxanes --- tissue engineering --- UHPLC-MS/MS --- metformin --- verapamil --- drug interaction --- organic cation transporter 2 --- renal excretion --- acute renal failure --- gentamicin --- cisplatin --- hepatic CYP3A1(23) --- creatinine clearance --- renal clearance --- nonrenal clearance