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Leg Ulcer --- Foot Ulcer
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Diabetic Foot. --- Diabetic Feet --- Foot Ulcer, Diabetic --- Feet, Diabetic --- Foot, Diabetic --- Diabetic Foot
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Fully updated, now in full color, this latest edition of Levin and O'Neal's The Diabetic Foot continues the work's proud tradition of providing the best diagnostic and management information for the challenging problems faced by patients with diabetic foot problems. With tips and pearls in every chapter, expansive color photographs, and its focus on team care, this classic reference is a must-have for anyone who cares for diabetic patients!Provide balanced, coordinated ""team"" care with multidisciplinary perspectives from diverse health professionals who care for diabetic patients wi
Foot --- Diabetes --- Diseases. --- Complications. --- Surgery. --- Podiatry --- Foot diseases --- Complications and sequelae --- Diabetic Foot --- Diabetic Feet --- Foot Ulcer, Diabetic --- Feet, Diabetic --- Foot, Diabetic --- Complications --- Diseases --- Surgery
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The most common chronic complication of diabetes mellitus (DM) is diabetic foot ulcers (DFUs), with a prevalence of four to ten percent among DM patients. Local circulation is an essential requirement for efficient wound healing, providing sufficient oxygen and nutrient delivery. Therefore it is possible that compression therapies can improve local circulation and improve clinical outcomes for patients with DFUs, as has been demonstrated for other wound types. Compression therapies apply controlled external pressure to promote local circulation by simulating vasodilation or reduction of venous congestion and edema. The controlled external pressure is applied using bandages, specialized stockings, or inflatable garments. Intermittent pneumatic compression (IPC) is a compression therapy utilizing sleeves that are inflated to a defined pressure before being deflated, simulating the effect of walking and weight-bearing on the venous system. A related treatment called compressed air massage utilizes a stream of compressed air directly on the affected area and may have similar local circulation effects. However, DFUs are a unique wound type and are often accompanied by contraindications for compression therapy including ischemia and peripheral vascular disease (PVD). The purpose of this report is to retrieve and review existing clinical efficacy evidence for compression therapy in the treatment of DFUs. Additionally this report aims to retrieve and review evidence for compression therapy cost-effectiveness, and to retrieve and review the existing compression therapy guidelines for the treatment of DFUs.
Bandages and bandaging. --- Foot --- Diabetics --- Ulcers. --- Care. --- Diabetes --- Wireless communication systems --- Patient monitoring --- Foot Ulcer --- Diabetic Foot --- Intermittent Pneumatic Compression Devices. --- Diabetes Complications --- Clinical medicine --- Clinical trial --- Diabetic foot ulcer --- Evidence-based medicine --- Health --- Health care --- Health sciences --- Medical guideline --- Medical specialties --- Medicine --- Ulcers --- Complications --- Safety measures. --- Equipment and supplies. --- therapy.
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Debridement is the removal of necrotic tissue, foreign debris, bacterial growth, callus, wound edge, and wound bed tissue from chronic wounds in order to stimulate the wound healing process. Stimulation of wound healing mediated by debridement is thought to occur by the conversion of a chronic non-healing wound environment to an acute healing environment through the removal of cells that are not responsive to endogenous healing stimuli. Debridement is used commonly in standard wound treatment of diabetic foot ulcers (DFUs). Methods of debridement include surgery (sharp debridement), chemical debridement (antiseptics, polysaccharide beads, pastes), autolytic (hydrogels, hydrocolloids and transparent films), biosurgery (maggots), mechanical (hydrodebridement), and biochemical debridement (enzyme preparations). Callus is a buildup of keratinized skin formed under conditions of repeated pressure or friction and may contribute to ulcer formation by creating focal areas of high plantar pressure. The debridement of callus has been proposed to be relevant for both treatment and prevention of DFU. The purpose of this report is to retrieve and review existing evidence of comparative clinical effectiveness of different methods of debridement for the treatment of DFUs. Additionally examined in this report is the clinical effectiveness for treatment and prevention of DFU using callus debridement. Cost-effectiveness, and existing debridement guidelines for the treatment of DFUs will also be reviewed.
Diabetic Foot --- Debridement --- Treatment Outcome --- Cost-Benefit Analysis --- surgery. --- economics. --- methods. --- Canada --- Foot --- Debridement. --- Diabetes --- Wireless communication systems --- Patient monitoring --- Foot Ulcer --- Diabetes Complications --- Chronic wound --- Clinical medicine --- Clinical trial --- Cohort study --- Diabetic foot ulcer --- Health --- Health care --- Health sciences --- Medical guideline --- Ulcers --- Complications --- Safety measures. --- Equipment and supplies. --- therapy.
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The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity.
Charcot joints. --- Diabetes --- Diabetic Foot --- Arthropathy, Neurogenic --- Complications. --- Charcot's Joint --- Arthropathies, Neurogenic --- Charcot Joint --- Charcots Joint --- Joint, Charcot's --- Neurogenic Arthropathies --- Neurogenic Arthropathy --- Diabetic Feet --- Foot Ulcer, Diabetic --- Feet, Diabetic --- Foot, Diabetic --- Charcot's joint --- Neuro-arthropathy --- Neurogenic arthropathy --- Neuropathic joint --- Joints --- Complications and sequelae --- Diseases --- Diabetes Complications
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In The Diabetic Foot: Medical and Surgical Management, 3rd Edition, a distinguished panel of clinicians provides a thorough update of the significant improvements in knowledge surrounding the pathogenesis of diabetic foot problems, as well as the optimal healthcare treatment for this debilitating condition. The authors, many practicing at the famous Joslin-Beth Israel Deaconess Foot Center, again illuminate the successful new multidisciplinary approach now clearly required for the successful treatment of diabetic foot. Drawing on the experiences of diabetologists, podiatrists, vascular surgeons, infectious disease specialists, orthotists, plastic and orthopedic surgeons, this invaluable third edition, so timely given the continued rise of diabetes and its complications, clearly describes established techniques known to be effective. This updated edition blends new knowledge with the time-tested principles of diabetic foot management and will be of significant value to all physicians and researchers with an interest in a state-of-the-art understanding of diabetic foot.
Diabetes -- Complications. --- Diabetic Foot -- therapy. --- Foot -- Diseases. --- Foot --- Diabetes --- Foot Ulcer --- Diabetic Angiopathies --- Diabetic Neuropathies --- Vascular Diseases --- Diabetes Complications --- Leg Ulcer --- Diabetes Mellitus --- Cardiovascular Diseases --- Skin Ulcer --- Endocrine System Diseases --- Diseases --- Skin Diseases --- Skin and Connective Tissue Diseases --- Diabetic Foot --- Medicine --- Surgery & Anesthesiology --- Health & Biological Sciences --- Clinical Endocrinology --- Surgery - General and By Type --- Complications --- Complications. --- Diseases. --- Foot diseases --- Complications and sequelae --- Medicine. --- Endocrinology. --- Medicine & Public Health. --- Podiatry --- Internal medicine --- Hormones --- Endocrinology .
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Ankle --- Foot --- Diabetes --- Ankle. --- Diabetes. --- Podiatry. --- Diabetic Foot. --- Diabetes Mellitus. --- Foot Diseases. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Feet --- Paw --- Paws --- Leg --- Ankle joint --- Joints --- Podiatry --- Foot Disease --- Diabetes Insipidus --- Glucose Intolerance --- Diabetic Feet --- Foot Ulcer, Diabetic --- Feet, Diabetic --- Foot, Diabetic --- Regio tarsalis --- Tarsus --- Ankles --- Ankle Joint --- Tarsal Bones --- Diseases --- Complications --- Complications. --- Diseases. --- Complications and sequelae --- Diabetic foot --- Levin and O'Neal's The diabetic foot --- Pathology --- Surgery
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Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines. Recent examples of advanced nanoparticle-based nanomedicines are COVID-19 RNA vaccines. Regardless of the delivery route of the NPs into the body (intravenous or subcutaneous injection, oral, intranasal, etc.), NPs inevitably come into contact with immune cells, such as macrophages. Macrophages are phagocytizing cells that determine the fate and the lifetime of NPs in relevant biological fluids or tissues, which has consequences for both nanosafety and nanomedicine. The aim of this Special Issue is to cover recent advancements in our understanding of NP–macrophage interactions, with a focus on in vitro models for nanosafety and novel nanomedicine approaches that allow the modulation of the immunological profile of macrophages. The current Special Issue compiles nine papers: seven research articles and two review articles. The original articles include studies on the interaction of different nanomaterials, such as multi-walled carbon nanotubes (MWCNTs), amorphous silica, gold nanoparticles, lipid carriers, and microspheres, with macrophages in different scenarios.
Medicine --- chronic wound --- device --- foot ulcer --- inflammation --- wound healing --- macrophage --- nanomaterial --- nanoparticle --- drug delivery --- immune system --- anti-inflammatory --- innate immunity --- osteoarthritis --- rifabutin --- nanostructured lipid carriers --- cell uptake --- Caco-2 cells --- oral administration --- Crohn’s disease --- nanomaterials --- macrophages --- class A type 1 scavenger receptors --- cytotoxicity --- macrophage–nanoparticle interaction --- monocytes --- gold nanoparticles --- in vitro models --- innate memory --- 2D cultures --- 3D cultures --- carbon nanotube --- scavenger receptor --- phagocytosis --- protein corona --- bovine serum albumin --- synthetic amorphous silica --- in vitro testing --- NR8383 alveolar macrophage --- ICP-MS analysis of cell bound SiO2 --- multi-walled carbon nanotubes --- nanoparticles --- chemokines --- transcriptomics --- zebrafish --- n/a --- Crohn's disease --- macrophage-nanoparticle interaction
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Based on a fundamental understanding of the interaction between bacteria and nanomaterials, this book highlights the latest research on the antimicrobial properties of nanomaterials and provides an invaluable blueprint for improving the antimicrobial performance of devices and products. This book introduces the reader to the progress being made in the field, followed by an outline of applications in different areas. Various methods and techniques of synthesis and characterization are detailed. The content provides insight into the ongoing research, current trends, and technical challenges in this rapidly progressing field. Therefore, this book is highly suitable for materials scientists, engineers, biologists, and technologists.
Research & information: general --- Biology, life sciences --- boron nitride --- chitosan --- polyhydroxyalkanoate --- nanocomposite --- biocompatible --- antibacterial --- titanate nanotubes --- TNT --- Ag --- Escherichia coli --- Staphylococcus epidermidis --- antimicrobial --- layer-by-layer --- coatings --- Nafion --- multilayers --- essential oil --- encapsulation --- bovine casein --- antifungal activity --- fruit preservation --- antibacterial activity --- photocatalyst --- titania --- nanomaterial --- doping --- Staphylococcus aureus --- reactive oxygen species --- silver nanoparticle --- visible light --- nanoscale additive manufacturing --- surface nanopatterns --- antibacterial effects --- controlled disorder --- interspace --- zinc oxide --- electrochemical synthesis --- BAC --- PDDA --- nanorod --- XPS --- TEM --- B. subtilis --- silver nanoparticles --- carboxymethyl-cellulose --- composite --- cytotoxicity --- nanoparticle --- drug delivery system --- diabetes mellitus --- wound healing --- diabetic foot ulcer --- pathophysiology --- hybrid nanostructures --- nanovesicles --- nanoparticles --- copper --- antibiofilm --- metal nanoparticles --- fiber material --- bioluminescent cells --- n/a
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