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RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. B
G proteins. --- G proteins --- G proteins --- Physiological effect. --- Pathophysiology.
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G proteins --- G proteins --- Receptors. --- Structure.
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G Proteins
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G proteins --- Immunology. --- Receptors.
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G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about GPCR trafficking.
G proteins --- Receptors.
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GTPases in Cellular Signaling studies several aspects of cellular signaling including an extensive overview of GTPases and related concepts. It includes definitions of GTPASES in Signaling, GTPASES in Prokaryotes and latest trends in the cellular signaling. Provides the reader with insights into the development of its understanding, so as to innovate technologies in this context.
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G proteins --- Structure-activity relationships --- Congresses.
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G proteins --- G proteins --- Neurotransmitter receptors --- Guanine Nucleotide Regulatory Protein --- Receptors, Endogenous Substances --- Receptors, Synaptic
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Second messengers (Biochemistry) --- G proteins --- Cellular signal transduction
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