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A “genotype"" is essentially an organism's full hereditary information which is obtained from its parents. A ""phenotype"" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.

precision medicine informatics --- n/a --- drug sensitivity --- chromatin modification --- cell lines --- biocuration --- neurodegeneration --- multivariate analysis --- artificial intelligence --- epigenetics --- missing data --- sequencing --- clinical data --- class imbalance --- integrative analytics --- algorithm development for network integration --- deep phenotype --- non-omics data --- feature selection --- Gene Ontology --- miRNA–gene expression networks --- omics data --- plot visualization --- Alzheimer’s disease --- tissue classification --- epidemiological data --- proteomic analysis --- genotype --- RNA expression --- indirect effect --- multi-omics --- dementia --- multiomics integration --- data integration --- phenomics --- network topology analysis --- challenges --- transcriptome --- enrichment analysis --- regulatory genomics --- scalability --- heterogeneous data --- systemic lupus erythematosus --- database --- microtubule-associated protein tau --- disease variants --- genomics --- joint modeling --- distance correlation --- annotation --- phenotype --- direct effect --- curse of dimensionality --- gene–environment interactions --- logic forest --- machine learning --- KEGG pathways --- multivariate causal mediation --- amyloid-beta --- bioinformatics pipelines --- support vector machine --- pharmacogenomics --- candidate genes --- tissue-specific expressed genes --- cognitive impairment --- causal inference --- miRNA-gene expression networks --- Alzheimer's disease --- gene-environment interactions

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We rely on environmental health scientists to document the presence of chemicals where we live, work, and play and to provide an empirical basis for public policy. In the last decades of the 20th century, environmental health scientists began to shift their focus deep within the human body, and to the molecular level, in order to investigate gene-environment interactions. In Exposed Science, Sara Shostak analyzes the rise of gene-environment interaction in the environmental health sciences and examines its consequences for how we understand and seek to protect population health. Drawing on in-depth interviews and ethnographic observation, Shostak demonstrates that what we know - and what we don't know - about the vulnerabilities of our bodies to environmental hazards is profoundly shaped by environmental health scientists' efforts to address the structural vulnerabilities of their field. She then takes up the political effects of this research, both from the perspective of those who seek to establish genomic technologies as a new basis for environmental regulation, and from the perspective of environmental justice activists, who are concerned that that their efforts to redress the social, political, and economical inequalities that put people at risk of environmental exposure will be undermined by molecular explanations of environmental health and illness. Exposed Science thus offers critically important new ways of understanding and engaging with the emergence of gene-environment interaction as a focal concern of environmental health science, policy-making, and activism.

Health risk assessment. --- Pollution. --- Environmental health --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Medicine, Preventive --- Public health --- Risk assessment --- Environmental quality --- Health --- Health ecology --- Environmental engineering --- Health risk assessment --- Chemical pollution --- Chemicals --- Contamination of environment --- Environmental pollution --- Pollution --- Contamination (Technology) --- Asbestos abatement --- Bioremediation --- Factory and trade waste --- Hazardous waste site remediation --- Hazardous wastes --- In situ remediation --- Lead abatement --- Pollutants --- Refuse and refuse disposal --- Political aspects. --- Health aspects --- Environmental aspects --- Environmental aspects. --- Hygiène du milieu --- Risques pour la santé --- Aspect politique --- Aspect de l'environnement --- Evaluation --- 20th century. --- engaging. --- environmental hazards. --- environmental health sciences. --- environmental health scientists. --- environmental justice activists. --- environmental regulation. --- ethnographic observation. --- experiments. --- gene environment interactions. --- genomic technologies. --- health policy. --- history of medicine. --- human condition. --- in depth interviews. --- medical. --- medicine. --- page turner. --- political effects. --- population health. --- public policy. --- science and technology. --- scientists. --- structural vulnerabilities.

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Eating disorders (ED) are a group of mental disorders characterized by an altered food intake and the presence of inappropriate behaviors and thoughts about weight and shape. All EDs lead to physical and psychosocial functioning impairments in the patients which, in turn, may contribute to the persistence of the disease. The severity of EDs has been highlighted by their chronicity, medical complications, comorbidity, and high rates of mortality. Therefore, to address this important health issue, the current Special Issue collected 21 articles (i.e., three reviews and 18 research articles) focusing on the most recent and relevant scientific findings regarding advances in ED, such as genetic and epigenetic factors, biomarkers, comorbidity, clinical phenotypes, neurocognition, treatment predictors, and treatment models and therapeutic targets. Altogether, we believe that the articles contained in this Special Issue have largely achieved the initial objective of providing increased knowledge about the pathogenesis, the risk factors, the maintenance factors, and the most appropriate treatments tools for ED.

Humanities --- Social interaction --- anorexia nervosa --- cognitive interpersonal model --- severe enduring --- physical activity --- accelerometry --- weight gain --- eating disorders --- malnutrition --- neuroimaging --- fractal dimension --- cortical complexity --- food craving --- food addiction --- emotion regulation --- event related potentials --- EEG --- neurophysiology --- psychopathology --- ASD --- comorbidity --- emotion recognition --- attention --- sensory sensitivity --- autism --- Avon Longitudinal Study of Parents and Children (ALSPAC) --- body mass index --- disordered eating behaviors --- disordered eating cognitions --- polygenic scores --- non-suicidal self-injury --- temperament --- eating disorder --- adolescence --- nocturnal eating syndrome --- sleep-related eating disorder --- parasomnia --- delayed sleep-wake phase --- MUPS --- magnetic resonance spectroscopy --- MRS --- insula --- glutamate --- N-acetylaspartate --- NAA --- epigenetics --- bulimia nervosa --- DNA methylation --- gene-environment interactions --- caloric intake --- refeeding syndrome --- refeeding protocol --- children and adolescents --- parents --- carers --- intervention --- workshop --- online intervention --- alcohol and/or drug abuse --- substance use disorder --- executive functions --- impulsivity --- emotional dysregulation --- deep brain stimulation --- psychosurgery --- clinical trial --- subcallosal cingulate --- nucleus accumbens --- high expressed emotion --- caregivers --- dance students --- disordered eating attitudes --- Eating Attitudes Test-26 (EAT-26) --- mesomorphy --- ectomorphy --- Receiver Operating Characteristics (ROC) curve analysis --- attention-deficit/hyperactivity disorder --- ADHD --- longitudinal --- treatment outcome --- dropout --- rTMS --- treatment --- anorexia --- bulimia --- binge eating disorders --- restrictive anorexia nervosa --- weight recovery --- animal models --- acyl-ghrelin --- desacyl-ghrelin --- chronic food restriction --- virtual reality --- fear of gaining weight --- body anxiety --- body image disturbances --- body-related attentional bias --- n/a

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Next year (2018), we will be celebrating the 15th anniversary of the International Journal of Environmental Research and Public Health—IJERPH (ISSN 1660-4601). Hence, we are currently organizing a Special Issue to commemorate this important milestone. Founded in 2004, IJERPH has experienced a tremendous growth in terms of the number and quality of scientific publications. With a 2016 impact factor of 2.101, IJERPH now ranks among the top international journals in the emerging field of environmental research and public health. As described on our website (https://www.mdpi.com/journal/ijerph), IJERPH is a peer-reviewed journal that focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health. Its primary areas of research interests include: Gene-environment interactions Environmental genomics and proteomics Environmental toxicology, mutagenesis and carcinogenesis Environmental epidemiology and disease control Health risk assessment and management Ecotoxicology, and ecological risk assessment and management Natural resources damage assessment Environmental chemistry and computational modeling Environmental policy and management Environmental engineering and biotechnology Emerging issues in environmental health and diseases Environmental education and public health To help celebrate the 15th anniversary, you are kindly invited to submit original articles, critical reviews, research notes, and short communications on any of the above-listed topics. Please also encourage any of our colleagues who may be interested to submit manuscripts. We expect that this issue will attract considerable attention, as we prepare to celebrate the excellent scientific contributions and socio-economic impacts of IJERPH over the past 15 years.

Research & information: general --- transportation noise --- MTNR1B gene --- rs10830963 --- diabetes --- glycosylated hemoglobin --- circadian sleep-wake cycle --- gene-environment interactions --- adults --- cohort study --- metal mobility --- soil flushing --- soil reclamation --- agricultural soil --- EDDS deficiency --- child sexual abuse --- adolescents --- girls --- boys --- gender differences --- legal proceedings --- child-friendly justice --- prevention --- cervical Arabin pessary --- cerclage --- second trimester of pregnancy --- sepiolite --- adsorption --- potentially toxic elements --- modification --- regeneration --- Xiangjiang River --- air pollution --- neighborhood deprivation index --- preterm birth --- spatial approach --- participatory research --- second hand smoking --- communication media --- vulnerable populations --- migrants --- health care research --- quality assurance --- hospital management --- health inequities --- environmental vulnerability --- multi-criteria spatial analysis --- risk management tool --- hazardous substance --- road accidents --- online hate --- hate speech --- bystander --- perpetrator --- online disinhibition --- online discrimination --- cyber aggression --- Bothrops lanceolatus --- envenomation --- snakebite --- bacteria --- infection --- antibiotic susceptibility --- ADL --- disability --- health --- home --- usability --- parenting desire --- lesbian --- gay --- minority stress --- mediation --- demographic factor --- EQ-5D --- health-related quality of life --- depression --- family planning --- Bayesian --- spatial --- RDHS --- Rwanda --- suicide --- premature mortality --- young men --- Greenland --- Denmark --- head injury --- incidence --- national health insurance --- population-based study --- mortality --- traumatic brain injury --- polycystic ovary syndrome --- self-efficacy --- optimism --- acceptance of illness --- September 11 terrorist attacks --- pilot aircraft-assisted suicide --- copycat effect --- obesity --- endoscopy --- Helicobacter pylori --- BMI --- Saudi patients --- urban lake --- comprehensive nutrition status Index --- heavy metals --- health risk --- fuzzy comprehensive method --- physical fitness --- Mediterranean diet --- body composition --- dementia --- health services --- resource utilization --- dementia care --- informal care --- formal care --- cognitive disorder --- physical activity in pregnancy --- PPAQ --- quality of life --- WHOQoL-Bref --- pregnant women --- food availability --- eating away from home --- household food spending --- trace elements --- concentration --- microwave digester --- Wuhan --- soil contamination --- ecological risk --- tuberculosis --- screening for tuberculosis --- public health --- immigrants --- health impact assessments --- premature death --- equity impact --- health impact --- reduction of air pollution --- environmental inequalities --- spatial analysis --- small area --- AirQ --- traffic congestion --- activity-travel patterns --- real-time traffic data --- the uncertain geographic context problem (UGCoP) --- the neighborhood effect averaging problem (NEAP) --- evaluation --- method --- policy --- strategy --- social --- trend --- winter tourism --- climate change --- snow abundance index --- meteorological suitability index --- copula function --- spatial suitability assessment --- oral surgery --- oral medicine --- leucoplakia --- hyperkeratosis --- laser --- electronic waste --- informal recycling --- PBDEs --- soil --- dust --- Nigeria --- aerobic capacity --- attrition --- change-of-direction speed --- deputy sheriff --- graduation --- high-intensity running --- police --- strength endurance --- tactical --- roadside exposure --- inflammation biomarker --- Nepal --- PM2.5 --- oily sludge --- incineration --- kinetic --- modeling --- differential/integral method --- engineering --- curriculum proposals --- arbuscular mycorrhizal fungi --- global change --- grassland ecosystem --- stoichiometry --- phosphorus limitation --- unsafe behavior --- targeted intervention --- coal miners --- safety management --- bioaerosols --- influenza virus --- ferret animal model --- aerosol chamber --- dengue fever --- Aedes albopictus --- living environment --- logistic regression analysis --- China --- human capital --- multilevel linear regression --- self-rated mental health --- social capital --- groundwater --- iron and manganese removal --- biofilter --- food contamination --- gastrointestinal diseases --- morbidity --- deep neural networks --- evolutionary learning --- health literacy --- adolescent health --- Mexico --- health disparities --- motivation --- videogaming --- psychopathology --- adverse childhood experiences (ACEs) --- Hungarian representative adult sample --- opinion poll --- ACE Score Calculator --- influenza vaccination --- pneumonia --- population-based case-control study --- adolescent --- risk factors --- psychosocial --- socio-environmental --- behavior --- United States --- Latinos --- physical education --- social and emotional learning --- sport education model --- subjective well-being --- trait emotional intelligence --- social anxiety

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• Reference Manager
• EndNote
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Next year (2018), we will be celebrating the 15th anniversary of the International Journal of Environmental Research and Public Health—IJERPH (ISSN 1660-4601). Hence, we are currently organizing a Special Issue to commemorate this important milestone. Founded in 2004, IJERPH has experienced a tremendous growth in terms of the number and quality of scientific publications. With a 2016 impact factor of 2.101, IJERPH now ranks among the top international journals in the emerging field of environmental research and public health. As described on our website (https://www.mdpi.com/journal/ijerph), IJERPH is a peer-reviewed journal that focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health. Its primary areas of research interests include: Gene-environment interactions Environmental genomics and proteomics Environmental toxicology, mutagenesis and carcinogenesis Environmental epidemiology and disease control Health risk assessment and management Ecotoxicology, and ecological risk assessment and management Natural resources damage assessment Environmental chemistry and computational modeling Environmental policy and management Environmental engineering and biotechnology Emerging issues in environmental health and diseases Environmental education and public health To help celebrate the 15th anniversary, you are kindly invited to submit original articles, critical reviews, research notes, and short communications on any of the above-listed topics. Please also encourage any of our colleagues who may be interested to submit manuscripts. We expect that this issue will attract considerable attention, as we prepare to celebrate the excellent scientific contributions and socio-economic impacts of IJERPH over the past 15 years.

transportation noise --- MTNR1B gene --- rs10830963 --- diabetes --- glycosylated hemoglobin --- circadian sleep-wake cycle --- gene-environment interactions --- adults --- cohort study --- metal mobility --- soil flushing --- soil reclamation --- agricultural soil --- EDDS deficiency --- child sexual abuse --- adolescents --- girls --- boys --- gender differences --- legal proceedings --- child-friendly justice --- prevention --- cervical Arabin pessary --- cerclage --- second trimester of pregnancy --- sepiolite --- adsorption --- potentially toxic elements --- modification --- regeneration --- Xiangjiang River --- air pollution --- neighborhood deprivation index --- preterm birth --- spatial approach --- participatory research --- second hand smoking --- communication media --- vulnerable populations --- migrants --- health care research --- quality assurance --- hospital management --- health inequities --- environmental vulnerability --- multi-criteria spatial analysis --- risk management tool --- hazardous substance --- road accidents --- online hate --- hate speech --- bystander --- perpetrator --- online disinhibition --- online discrimination --- cyber aggression --- Bothrops lanceolatus --- envenomation --- snakebite --- bacteria --- infection --- antibiotic susceptibility --- ADL --- disability --- health --- home --- usability --- parenting desire --- lesbian --- gay --- minority stress --- mediation --- demographic factor --- EQ-5D --- health-related quality of life --- depression --- family planning --- Bayesian --- spatial --- RDHS --- Rwanda --- suicide --- premature mortality --- young men --- Greenland --- Denmark --- head injury --- incidence --- national health insurance --- population-based study --- mortality --- traumatic brain injury --- polycystic ovary syndrome --- self-efficacy --- optimism --- acceptance of illness --- September 11 terrorist attacks --- pilot aircraft-assisted suicide --- copycat effect --- obesity --- endoscopy --- Helicobacter pylori --- BMI --- Saudi patients --- urban lake --- comprehensive nutrition status Index --- heavy metals --- health risk --- fuzzy comprehensive method --- physical fitness --- Mediterranean diet --- body composition --- dementia --- health services --- resource utilization --- dementia care --- informal care --- formal care --- cognitive disorder --- physical activity in pregnancy --- PPAQ --- quality of life --- WHOQoL-Bref --- pregnant women --- food availability --- eating away from home --- household food spending --- trace elements --- concentration --- microwave digester --- Wuhan --- soil contamination --- ecological risk --- tuberculosis --- screening for tuberculosis --- public health --- immigrants --- health impact assessments --- premature death --- equity impact --- health impact --- reduction of air pollution --- environmental inequalities --- spatial analysis --- small area --- AirQ --- traffic congestion --- activity-travel patterns --- real-time traffic data --- the uncertain geographic context problem (UGCoP) --- the neighborhood effect averaging problem (NEAP) --- evaluation --- method --- policy --- strategy --- social --- trend --- winter tourism --- climate change --- snow abundance index --- meteorological suitability index --- copula function --- spatial suitability assessment --- oral surgery --- oral medicine --- leucoplakia --- hyperkeratosis --- laser --- electronic waste --- informal recycling --- PBDEs --- soil --- dust --- Nigeria --- aerobic capacity --- attrition --- change-of-direction speed --- deputy sheriff --- graduation --- high-intensity running --- police --- strength endurance --- tactical --- roadside exposure --- inflammation biomarker --- Nepal --- PM2.5 --- oily sludge --- incineration --- kinetic --- modeling --- differential/integral method --- engineering --- curriculum proposals --- arbuscular mycorrhizal fungi --- global change --- grassland ecosystem --- stoichiometry --- phosphorus limitation --- unsafe behavior --- targeted intervention --- coal miners --- safety management --- bioaerosols --- influenza virus --- ferret animal model --- aerosol chamber --- dengue fever --- Aedes albopictus --- living environment --- logistic regression analysis --- China --- human capital --- multilevel linear regression --- self-rated mental health --- social capital --- groundwater --- iron and manganese removal --- biofilter --- food contamination --- gastrointestinal diseases --- morbidity --- deep neural networks --- evolutionary learning --- health literacy --- adolescent health --- Mexico --- health disparities --- motivation --- videogaming --- psychopathology --- adverse childhood experiences (ACEs) --- Hungarian representative adult sample --- opinion poll --- ACE Score Calculator --- influenza vaccination --- pneumonia --- population-based case-control study --- adolescent --- risk factors --- psychosocial --- socio-environmental --- behavior --- United States --- Latinos --- physical education --- social and emotional learning --- sport education model --- subjective well-being --- trait emotional intelligence --- social anxiety