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"Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders."--Provided by publisher.

Nutrition --- Genetic aspects. --- Epigenomics. --- Nutritional Physiological Phenomena --- Epigenesis, Genetic. --- Genome, Human. --- genetics. --- Human Genome --- Genomes, Human --- Human Genomes --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Epigenetics --- Epigenetic --- Epigenomic --- Genetics

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This work provides guidance on the principles underlying modern human molecular genetics. This new edition has been updated to take account of the changes in our understanding of this field since the late 1990s.

Human molecular genetics. --- Genome, Human. --- Molecular Biology. --- Genetics, Medical. --- Génétique moléculaire humaine --- Génome humain. --- Biologie moléculaire --- Génétique médicale --- Molecular biology --- Human genetics --- Human molecular genetics --- Molecular genetics --- Genome, Human --- Molecular Biology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Human Genome --- Genomes, Human --- Human Genomes --- Genetics, Medical --- Genetica --- Erfelijkheidsleer

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The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine.

Medicine. --- Human genetics. --- Molecular biology. --- Biomedicine. --- Human Genetics. --- Molecular Medicine. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Epigenomics. --- Gene Expression Regulation. --- Genome, Human. --- Human Genome --- Genomes, Human --- Human Genomes --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Epigenetics --- Epigenetic --- Epigenomic --- Medical genetics. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Human genetics --- Human gene mapping --- Chromosome Mapping. --- Genome, Human. --- Ethics, Medical. --- Medical Ethics --- Medicine --- Professionalism --- Bioethics --- Human Genome --- Genomes, Human --- Human Genomes --- Genome Mapping --- Gene Mapping --- Linkage Mapping --- Chromosome Mappings --- Gene Mappings --- Genome Mappings --- Linkage Mappings --- Mapping, Chromosome --- Mapping, Gene --- Mapping, Genome --- Mapping, Linkage --- Mappings, Chromosome --- Mappings, Gene --- Mappings, Genome --- Mappings, Linkage --- Cytogenetics --- Genetic Markers --- Cytogenetic Analysis --- Gene Order --- Synteny --- Human chromosome mapping --- Human genome mapping --- Mapping, Human gene --- Gene mapping --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- History. --- Philosophy. --- Moral and ethical aspects. --- ethics --- Human Genome Project --- Human Genome Project. --- HGP --- H.G.P.

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Law --- Human genetics --- Professional ethics. Deontology --- Medical genetics --- Genetics, Medical --- Génétique humaine --- Génétique médicale --- Social aspects --- Congresses --- congresses --- Aspect social --- Congrès --- Ethics, Medical. --- Genetic Engineering. --- Genetics, Medical. --- Genome, Human. --- -Medical genetics --- -#GBIB:CBMER --- Clinical genetics --- Diseases --- Heredity of disease --- Medical sciences --- Pathology --- Genetic disorders --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Human Genome --- Genomes, Human --- Human Genomes --- Human Genetics --- Medical Genetics --- Genetics, Human --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Engineering, Genetic --- Intervention, Genetic --- Genetic Intervention --- Genetic Interventions --- Interventions, Genetic --- Biotechnology --- Cloning, Molecular --- DNA, Recombinant --- Industrial Microbiology --- Artificial Gene Fusion --- Organisms, Genetically Modified --- Animals, Genetically Modified --- Plants, Genetically Modified --- Medical Ethics --- Medicine --- Professionalism --- Bioethics --- legislation & jurisprudence. --- -Congresses --- Genetic aspects --- ethics --- United States. --- Congresses. --- Génétique humaine --- Génétique médicale --- Congrès --- congresses. --- Ethics, Medical --- Genetic Engineering --- Genome, Human --- #GBIB:CBMER --- Social aspects&delete& --- legislation & jurisprudence --- GENOME, HUMAN --- JURISPRUDENCE --- ETHICS --- CONGRESSES