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This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.Highlights* Polymeric, cellular, and molecular drug delivery* Neuropharmacology* Blood-brain barrier* Central nervous system

Neurochemistry. --- Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Biochemistry --- Neurosciences --- Blood-vessels

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Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels

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This Special Issue of Pharmaceutics, "Advanced Blood-Brain Barrier Drug Delivery," comprises 16 articles or reviews, which cover a cross-section of brain drug delivery for either small-molecule or large-molecule therapeutics.

Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels

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Barrière hémato-encéphalique --- Bloed-liquor barriere --- Blood-brain barrier --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Blood-Brain Barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- drug effects. --- physiology. --- Blood-vessels --- Blood-brain barrier. --- Drug effects. --- Physiology. --- drug effects --- physiology

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Vascular Mechanisms in CNS Trauma focuses on the vascular aspects of brain and spinal cord trauma.  Twenty nine chapters are arranged in three sections—Molecular Mechanisms; Experimental Models and Methods; and Clinical Challenges and Opportunities.  The first section addresses topics in the basic biology of brain and spinal cord trauma, ranging from the pathophysiology of cerebral endothelial cells and gliovascular interactions to the role of stem cells in neurovascular repair. The second section covers experimental methods in rodent and in large animal models of CNS injury, as well as the use of biomaterials and biomarkers in studying the mechanisms of tissue response. The third section deals with clinical issues in the monitoring and treatment of the patient with traumatic injury of the brain and spinal cord. Contributors to the book include an integrated mix of basic scientists and clinicians from diverse institutions. By presenting salient issues in CNS trauma from a vascular perspective, this book should make a unique contribution to the understanding of traumatic brain and spinal cord injury.

Blood-brain barrier. --- Central nervous system. --- Nervous system, Central --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Neurosciences. --- Neurology. --- Neurobiology. --- Nervous system --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Neurosciences --- Medicine --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .