Listing 1 - 10 of 34 | << page >> |
Sort by
|
Choose an application
Immunology. Immunopathology --- IGE --- PHYSIOLOGY
Choose an application
The purpose of this study was to determine whether the presence of sputum specific immunoglobulin E antibodies was associated with clinical and inflammatory factors in non allergic asthma.Methods :The prospective study sample of 38 asthma adults, 18 non-allergic et 20 allergic asthma patients (18-75 year old) who underwent skin tests, FeNO measurements, spirometry and completed the asthma control tests (ACT, ACQ), the asthma quality of life questionnaire (AQLQ) and induced sputum analysis. Results: This work describes clinical similarities and differences between allergic and nonallergic asthmatics. Sputum total and specific IgE were detected at similar levels in both intrinsic and allergic asthma. Dust mite specific IgE levels in sputum are associated with poor levels of disease control and lower airway obstruction after adjusting for other relevant covariates.In addition, we also found a statistically significant association between total IgE production et ACT, ACQ-7 scores. L'asthme est une maladie bronchique chronique d'origine inflammatoire qui touche actuellement environ 300 millions de personnes parmi la population mondiale (5 à 10% de la population, y compris en Belgique). La morbidité élevée, notamment ces derniers d6ceonies, entraine une augmentation du coût des soins. L'asthme représente donc un réel problème de santé publique. (1-2] L'asthme est une maladie hétérogène notamment en terme de phénotypes de l'inflammation des voies aériennes. Il résulte d'interactions complexes entre la prédisposition génétique du sujet et les éléments de l'environnement. [3] Dans la majorité des cas, l'asthme est favorisé par une sensibilisation à des antigènes communs de l'environnement. La sensibilisation aux allergènes d'acariens touche près de 70% des asthmatiques. Cette sensibilisation constitue même un facteur de risque de développement d'asthme chez les enfants.La réponse immunitaire pathogénique dans l'asthme est la réponse immunitaire des lymphocytes T-CD4 de type 2.L'asthme intrinsèque a été décrit en 1940 par Rackeman. Selon l'étude et l'âge de la population étudiée, ce phénotype d'asthme va concerner entre 30 et 50% des asthmatiques. Il apparait en général plus tard dans la vie (30-40 ans), et touchera plus volontiers les femmes, en général sans antécédents familiaux, et est souvent associé à une intolérance à l'aspirine. Les tests cutanés aux allergènes communs sont négatifs et la concentration d'immunoglobuline E sérique est souvent normale. Les études précédentes ont montré que des IgE sont produites localement chez les asthmatiques allergiques et non allergiques, notamment dans l'expectoration induite. Mouthuy et al. ont montré qu'une partie de ces IgE sont spécifiques des allergènes de l'acarien domestique Dermatophagoïdes pteronyssinus.(4) Cependant, on a constaté une absence de relation entre la sensibilisation spécifique et les manifestations cliniques chez les asthmatiques non allergiques.Cela pourrait être dû de l'absence significative des récepteurs Fe à la surface des mastocytes chez les asthmatiques non allergiques. (5]On se pose la question de savoir si cette sensibilisation IgE est associée avec certains facteurs cliniques ou inflammatoires de l'asthme intrinsèque, afin de mieux comprendre leur pertinence dans l'asthme de manière globale.
Asthma --- Receptors, IgE --- Inflammation
Choose an application
RECEPTORS, FC --- PHOSPHORYLATION --- IMMUNOGLOBULINS --- BINDING SITES --- IGE
Choose an application
Hypersensitivity, Immediate. --- Atopic Hypersensitivity --- Hypersensitivity, Atopic --- Hypersensitivity, Type I --- IgE-Mediated Hypersensitivity --- Type I Hypersensitivity --- Atopic Hypersensitivities --- Hypersensitivities, Atopic --- Hypersensitivities, IgE-Mediated --- Hypersensitivities, Immediate --- Hypersensitivities, Type I --- Hypersensitivity, IgE-Mediated --- IgE Mediated Hypersensitivity --- IgE-Mediated Hypersensitivities --- Immediate Hypersensitivities --- Immediate Hypersensitivity --- Type I Hypersensitivities --- Antigen-Antibody Reactions --- Histamine --- Histamine H1 Antagonists --- Latex Hypersensitivity --- Allergy. --- Immediate hypersensitivity. --- Hypersensitivity, Immediate
Choose an application
Cellular immunity. --- Hypersensitivity, delayed. --- Allergy --- Hypersensitivity, Immediate. --- Atopic Hypersensitivity --- Hypersensitivity, Atopic --- Hypersensitivity, Type I --- IgE-Mediated Hypersensitivity --- Type I Hypersensitivity --- Atopic Hypersensitivities --- Hypersensitivities, Atopic --- Hypersensitivities, IgE-Mediated --- Hypersensitivities, Immediate --- Hypersensitivities, Type I --- Hypersensitivity, IgE-Mediated --- IgE Mediated Hypersensitivity --- IgE-Mediated Hypersensitivities --- Immediate Hypersensitivities --- Immediate Hypersensitivity --- Type I Hypersensitivities --- Antigen-Antibody Reactions --- Histamine --- Histamine H1 Antagonists --- Latex Hypersensitivity --- Hypersensitivity, Immediate --- Antigens --- Autoimmune Diseases --- Hypersensitivity
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Natural disease --- checkpoint molecules --- bats --- melanomacrophages --- IgE --- Devil Facial Tumour Disease --- immunization --- homeostasis --- inflammation --- comparative immunology
Choose an application
Immunology. Immunopathology --- #Lilly --- Mastocyten. Afscheiding. --- Mastocyten. Immunologie. --- Immunologie. --- Mastocytes. Immunologie. --- Mastocytes. Sécrétion. --- IGE --- MAST CELLS --- IMMUNOLOGY --- SECRETION
Choose an application
Autoimmunity --- Congresses --- Allergy --- Proteins --- Immunology --- Peptides --- Proteins - Immunology - Congresses. --- Peptides - Immunology - Congresses. --- Lymphocytes. --- Autoantibodies --- Ige --- Major histocompatibility complex --- Mast cells
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Medicine --- Immunology --- Natural disease --- checkpoint molecules --- bats --- melanomacrophages --- IgE --- Devil Facial Tumour Disease --- immunization --- homeostasis --- inflammation --- comparative immunology
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Medicine --- Immunology --- Natural disease --- checkpoint molecules --- bats --- melanomacrophages --- IgE --- Devil Facial Tumour Disease --- immunization --- homeostasis --- inflammation --- comparative immunology
Listing 1 - 10 of 34 | << page >> |
Sort by
|