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This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

Biomedicine. --- Pharmaceutical Sciences/Technology. --- Medicine. --- Pharmaceutical technology. --- Médecine --- Techniques pharmaceutiques --- Antibody-drug conjugates. --- Antibody-toxin conjugates. --- Drugs -- Research. --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Conjugates, Antibody-toxin --- Immunoconjugates --- Immunoglobulin-toxin conjugates --- Immunotoxins --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Conjugates, Antibody-drug --- Drug-antibody conjugates --- Drug immunoconjugates --- Drug-immunoglobulin conjugates --- Immunoconjugates, Drug --- Immunoglobulin-drug conjugates --- Bioconjugates --- Immunopharmacology --- Immunotoxicology --- Toxins --- Drugs --- Dosage forms --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology

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Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and t

Immunoenzyme technique. --- Antibody-drug conjugates. --- Immunology --- Drug development. --- Pharmaceutical biotechnology. --- Biopharmaceutical technology --- Drugs --- Biotechnology --- Pharmaceutical technology --- Development of drugs --- New drug development --- Pharmacology --- Pharmacy --- Conjugates, Antibody-drug --- Drug-antibody conjugates --- Drug immunoconjugates --- Drug-immunoglobulin conjugates --- Immunoconjugates, Drug --- Immunoglobulin-drug conjugates --- Bioconjugates --- Immunopharmacology --- Antibody enzyme techniques, Unlabeled --- Immunoperoxidase technique --- Peroxidase labeled antibody technique --- Enzymatic analysis --- Immunoassay --- Protein binding --- Technique. --- Development --- Dosage forms --- Technique

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The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.

Neurotoxic agents --- Drug targeting. --- Antibody-toxin conjugates --- Therapeutic use. --- Conjugates, Antibody-toxin --- Immunoconjugates --- Immunoglobulin-toxin conjugates --- Immunotoxins --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Bioconjugates --- Immunopharmacology --- Immunotoxicology --- Toxins --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Poisons --- Targeting --- Dosage forms --- Neurosurgery. --- Nerves --- Neurosurgery --- Surgery --- Nervous system --- Surgery.

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This volume is a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.

Biomedicine. --- Cancer Research. --- Drug Resistance. --- Pharmacology/Toxicology. --- Medicine. --- Oncology. --- Drug interactions. --- Toxicology. --- Médecine --- Cancérologie --- Médicaments --- Toxicologie --- Interaction --- Medicine --- Health & Biological Sciences --- Oncology --- Antibody-toxin conjugates. --- Cancer --- Treatment. --- Cancer therapy --- Cancer treatment --- Conjugates, Antibody-toxin --- Immunoconjugates --- Immunoglobulin-toxin conjugates --- Immunotoxins --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Therapy --- Cancer research. --- Drug resistance. --- Pharmacology. --- Bioconjugates --- Immunopharmacology --- Immunotoxicology --- Toxins --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Interactions, Drug --- Drugs --- Tumors --- Toxicology --- Side effects --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Resistance to drugs --- Cancer research --- Physiological effect

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Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students. .

Chronic diseases -- Immunological aspects. --- Immunology. --- Immunotoxicology. --- Chronic diseases --- Immunotoxicology --- Disease Attributes --- Diseases --- Immunoconjugates --- Hypersensitivity --- Disorders of Environmental Origin --- Noxae --- Toxic Actions --- Antibodies --- Pathologic Processes --- Immunoglobulins --- Chemical Actions and Uses --- Pathological Conditions, Signs and Symptoms --- Serum Globulins --- Chemicals and Drugs --- Immunoproteins --- Blood Proteins --- Globulins --- Proteins --- Amino Acids, Peptides, and Proteins --- Immunotoxins --- Environmental Illness --- Chronic Disease --- Immune System Diseases --- Medicine --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Internal Medicine --- Immunological aspects --- Immunological aspects. --- Immunologic toxicology --- Immunotoxicity --- Diseases, Chronic --- NCDs (Noncommunicable diseases) --- Non-communicable diseases --- Non-infectious diseases --- Noncommunicable diseases --- Medicine. --- Molecular biology. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Immunopathology --- Immunopharmacology --- Toxicology --- Toxicology. --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect