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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Pharmacology --- pharmacology innovation --- drug-design --- innovative therapies --- pharmaceutical innovations --- efficacy/risk ratio

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Clinical Medicine. --- Clinical Trials as Topic. --- Therapies, Investigational. --- Experimental Therapies --- Innovative Therapies --- Investigational Treatments --- Investigational Therapies --- Experimental Therapy --- Innovative Therapy --- Investigational Therapy --- Investigational Treatment --- Therapies, Experimental --- Therapies, Innovative --- Therapy, Experimental --- Therapy, Innovative --- Therapy, Investigational --- Treatment, Investigational --- Treatments, Investigational --- Clinical Trials as Topic --- Clinical Trial as Topic --- Clinical Protocols --- Drug Evaluation --- Drugs, Investigational --- Clinical Trials Data Monitoring Committees --- Therapies, Investigational --- Medicine, Clinical

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Clinical trials --- Therapies, Investigational --- Therapeutics --- Thérapeutique --- Etudes cliniques --- Periodicals. --- Périodiques --- Clinical Trials as Topic. --- Therapies, Investigational. --- Clinical trials. --- Therapeutics. --- clinical therapeutics --- clinical risk management --- Clinical Trials as Topic --- Experimental Therapies --- Innovative Therapies --- Investigational Treatments --- Investigational Therapies --- Experimental Therapy --- Innovative Therapy --- Investigational Therapy --- Investigational Treatment --- Therapies, Experimental --- Therapies, Innovative --- Therapy, Experimental --- Therapy, Innovative --- Therapy, Investigational --- Treatment, Investigational --- Treatments, Investigational --- Clinical Trial as Topic --- Clinical Protocols --- Drug Evaluation --- Drugs, Investigational --- Clinical Trials Data Monitoring Committees --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Research --- Human medicine

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Medicine --- Biomedical Research. --- Translational Medical Research. --- Therapies, Investigational. --- Knowledge Translation --- Translational Medical Science --- Translational Medicine --- Translational Research, Medical --- Translational Research --- Knowledge Translations --- Medical Research, Translational --- Medical Science, Translational --- Medical Sciences, Translational --- Medical Translational Research --- Medicine, Translational --- Research, Medical Translational --- Research, Translational --- Research, Translational Medical --- Science, Translational Medical --- Sciences, Translational Medical --- Translation, Knowledge --- Translational Medical Sciences --- Translational Researchs --- Translations, Knowledge --- National Center for Advancing Translational Sciences (U.S.) --- Experimental Therapies --- Innovative Therapies --- Investigational Treatments --- Investigational Therapies --- Experimental Therapy --- Innovative Therapy --- Investigational Therapy --- Investigational Treatment --- Therapies, Experimental --- Therapies, Innovative --- Therapy, Experimental --- Therapy, Innovative --- Therapy, Investigational --- Treatment, Investigational --- Treatments, Investigational --- Clinical Trials as Topic --- Experimental Medicine --- Investigational Medicine --- Investigative Medicine --- Research, Biomedical --- Research, Medical --- Medical Research --- Medicine, Experimental --- Medicine, Investigational --- Medicine, Investigative --- Animals, Laboratory --- Research --- Research. --- Human medicine --- oncology --- cardiology --- surgery --- paediatrics --- neurology --- gastroenterology

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Neurosciences --- Nervous system --- Research --- Periodicals. --- Diseases --- Recherche --- Périodiques --- Système nerveux --- Periodicals --- Maladies --- Nervous System Diseases. --- Translational Medical Research --- methods. --- Research. --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neural sciences --- Neurological sciences --- Neuroscience --- clinical neuroscience --- neuropsychiatric disorders --- neurodegenerative disorders --- systems neuroscience --- brain structure and function --- neuroimaging --- Therapies, Investigational --- Therapies, Investigational. --- Outcome and Process Assessment (Health Care) --- Nervous System Diseases --- methods --- Neurology --- Organs (Anatomy) --- Medical sciences --- Donabedian Model --- Donabedian Triad --- Outcome and Process Assessment --- Structure Process Outcome Triad --- Model, Donabedian --- Triad, Donabedian --- Knowledge Translation --- Translational Medical Science --- Translational Medicine --- Translational Research, Medical --- Translational Research --- Knowledge Translations --- Medical Research, Translational --- Medical Science, Translational --- Medical Sciences, Translational --- Medical Translational Research --- Medicine, Translational --- Research, Medical Translational --- Research, Translational --- Research, Translational Medical --- Science, Translational Medical --- Sciences, Translational Medical --- Translation, Knowledge --- Translational Medical Sciences --- Translational Researchs --- Translations, Knowledge --- National Center for Advancing Translational Sciences (U.S.) --- Experimental Therapies --- Innovative Therapies --- Investigational Treatments --- Investigational Therapies --- Experimental Therapy --- Innovative Therapy --- Investigational Therapy --- Investigational Treatment --- Therapies, Experimental --- Therapies, Innovative --- Therapy, Experimental --- Therapy, Innovative --- Therapy, Investigational --- Treatment, Investigational --- Treatments, Investigational --- Clinical Trials as Topic --- Health Sciences --- Translational Research, Biomedical --- Psychiatry --- Neuropathology