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Bacterial toxin–antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.

Medicine --- tuberculosis --- toxin-antitoxin systems --- bacterial cell death --- NAD+ --- stress-response --- toxin–antitoxin system --- mazF --- type II --- toxin --- mRNA interferase --- X-ray crystallography --- cognate interactions --- cross-interactions --- molecular insulation --- antitoxin --- TA systems --- addiction --- anti-addiction --- type I toxin–antitoxin system --- small protein toxin structure --- Fst/Ldr family --- toxin–antitoxin --- M. tuberculosis --- bacteria --- pathogenesis --- protein–protein interactions --- cross-talk --- protein interface --- tolerance --- persistence --- cross-resistance --- toxin-antitoxin system --- PemI/PemK --- Klebsiella pneumoniae --- toxin–antitoxin systems --- toxin activation --- antibacterial agents --- bacterial persistence --- Stenotrophomonas maltophilia --- opportunistic pathogen --- clinical origin --- environmental origin --- biofilm --- antibiotic resistance --- cell wall inhibition --- nucleotide hydrolysis --- uridine diphosphate-N-acetylglucosamine --- n/a --- type I toxin-antitoxin system --- toxin-antitoxin --- protein-protein interactions

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Precipitation is a well-recognized pillar in the global water and energy balances. The accurate and timely understanding of its characteristics at the global, regional and local scales is indispensable for a clearer insight on the mechanisms underlying the Earth’s atmosphere-ocean complex system. Precipitation is one of the elements that is documented to be greatly affected by climate change. In its various forms, precipitation comprises the primary source of freshwater, which is vital for the sustainability of almost all human activities. Its socio-economic significance is fundamental in managing this natural resource effectively, in applications ranging from irrigation to industrial and household usage. Remote sensing of precipitation is pursued through a broad spectrum of continuously enriched and upgraded instrumentation, embracing sensors which can be ground-based (e.g., weather radars), satellite-borne (e.g., passive or active space-borne sensors), underwater (e.g., hydrophones), aerial, or ship-borne. This volume hosts original research contributions on several aspects of remote sensing of precipitation, including applications which embrace the use of remote sensing in tackling issues such as precipitation estimation, seasonal characteristics of precipitation and frequency analysis, assessment of satellite precipitation products, storm prediction, rain microphysics and microstructure, and the comparison of satellite and numerical weather prediction precipitation products.

Research & information: general --- Northern China --- raindrop size distribution (DSD) --- microphysical processes --- quantitative precipitation estimation (QPE) --- satellite-based precipitation --- elevation --- extreme events --- IMERG-V05B and V06A --- MSWEP --- ERA5 --- SM2RAIN --- precipitation estimation --- soil moisture --- SM2RAIN-CCI --- SM2RAIN-ASCAT --- multi-satellite precipitation analysis (TMPA) --- error decomposition --- complex topography --- diverse climate --- gauge data --- IMERG --- TAHMO --- morphing --- field displacement --- TIGGE --- precipitation --- numerical weather prediction --- satellite --- flood --- spring 2019 --- Iran --- GPM IMERG --- satellite precipitation --- spatiotemporal analysis --- statistical distribution --- validation --- Mainland China --- GSMaP_NRT --- GSMaP_Gauge_NRT --- raindrop size distribution --- radar reflectivity --- raindrop spectrometer --- semi-arid area --- assessment --- Taiwan --- data assimilation --- WRF model --- high-impact rainfall events --- GNSS ZTD --- optimum interpolation --- geographically weighted regression --- downscaling --- Tianshan Mountains --- satellite precipitation products --- evaluation --- daily rainfall --- hourly rainfall --- GPM --- TRMM --- GNSS --- GNSS antenna --- receiver antenna calibration --- relative calibration --- Phase Center Variation --- U-blox --- goGPS --- Zenith Tropospheric Delay --- ZED-F9P --- GSMaP --- Nepal --- cloud radar --- thunderstorm --- LDR --- hydrometeor --- hydrometeor classification --- lightning --- discharge --- remote sensing --- SEVIRI --- ground radar --- precipitation interpolation --- geographically and temporally weighted regression --- time weight function --- geographically and temporally weighted regression kriging --- extreme rainfall --- polarimetric radar signatures --- quantitative precipitation estimation --- southern china --- reanalysis --- linear trends --- mainland China --- EDBF algorithm --- geospatial predictor --- spatial pattern --- weighted precipitation --- Cyprus --- bias correction --- object-based method --- storm events --- Thies --- disdrometer --- weather circulations --- convective --- stratiform --- rain spectra --- radar reflectivity–rain rate relationship --- gridded precipitation products --- abrupt changes --- trends --- statistical indicators --- agriculture --- Pakistan --- rainfall --- radar --- extreme precipitation --- spatial bootstrap --- Louisiana --- annual maxima --- n/a --- radar reflectivity-rain rate relationship

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Precipitation is a well-recognized pillar in the global water and energy balances. The accurate and timely understanding of its characteristics at the global, regional and local scales is indispensable for a clearer insight on the mechanisms underlying the Earth’s atmosphere-ocean complex system. Precipitation is one of the elements that is documented to be greatly affected by climate change. In its various forms, precipitation comprises the primary source of freshwater, which is vital for the sustainability of almost all human activities. Its socio-economic significance is fundamental in managing this natural resource effectively, in applications ranging from irrigation to industrial and household usage. Remote sensing of precipitation is pursued through a broad spectrum of continuously enriched and upgraded instrumentation, embracing sensors which can be ground-based (e.g., weather radars), satellite-borne (e.g., passive or active space-borne sensors), underwater (e.g., hydrophones), aerial, or ship-borne. This volume hosts original research contributions on several aspects of remote sensing of precipitation, including applications which embrace the use of remote sensing in tackling issues such as precipitation estimation, seasonal characteristics of precipitation and frequency analysis, assessment of satellite precipitation products, storm prediction, rain microphysics and microstructure, and the comparison of satellite and numerical weather prediction precipitation products.

Research & information: general --- Northern China --- raindrop size distribution (DSD) --- microphysical processes --- quantitative precipitation estimation (QPE) --- satellite-based precipitation --- elevation --- extreme events --- IMERG-V05B and V06A --- MSWEP --- ERA5 --- SM2RAIN --- precipitation estimation --- soil moisture --- SM2RAIN-CCI --- SM2RAIN-ASCAT --- multi-satellite precipitation analysis (TMPA) --- error decomposition --- complex topography --- diverse climate --- gauge data --- IMERG --- TAHMO --- morphing --- field displacement --- TIGGE --- precipitation --- numerical weather prediction --- satellite --- flood --- spring 2019 --- Iran --- GPM IMERG --- satellite precipitation --- spatiotemporal analysis --- statistical distribution --- validation --- Mainland China --- GSMaP_NRT --- GSMaP_Gauge_NRT --- raindrop size distribution --- radar reflectivity --- raindrop spectrometer --- semi-arid area --- assessment --- Taiwan --- data assimilation --- WRF model --- high-impact rainfall events --- GNSS ZTD --- optimum interpolation --- geographically weighted regression --- downscaling --- Tianshan Mountains --- satellite precipitation products --- evaluation --- daily rainfall --- hourly rainfall --- GPM --- TRMM --- GNSS --- GNSS antenna --- receiver antenna calibration --- relative calibration --- Phase Center Variation --- U-blox --- goGPS --- Zenith Tropospheric Delay --- ZED-F9P --- GSMaP --- Nepal --- cloud radar --- thunderstorm --- LDR --- hydrometeor --- hydrometeor classification --- lightning --- discharge --- remote sensing --- SEVIRI --- ground radar --- precipitation interpolation --- geographically and temporally weighted regression --- time weight function --- geographically and temporally weighted regression kriging --- extreme rainfall --- polarimetric radar signatures --- quantitative precipitation estimation --- southern china --- reanalysis --- linear trends --- mainland China --- EDBF algorithm --- geospatial predictor --- spatial pattern --- weighted precipitation --- Cyprus --- bias correction --- object-based method --- storm events --- Thies --- disdrometer --- weather circulations --- convective --- stratiform --- rain spectra --- radar reflectivity–rain rate relationship --- gridded precipitation products --- abrupt changes --- trends --- statistical indicators --- agriculture --- Pakistan --- rainfall --- radar --- extreme precipitation --- spatial bootstrap --- Louisiana --- annual maxima --- n/a --- radar reflectivity-rain rate relationship

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Precipitation is a well-recognized pillar in the global water and energy balances. The accurate and timely understanding of its characteristics at the global, regional and local scales is indispensable for a clearer insight on the mechanisms underlying the Earth’s atmosphere-ocean complex system. Precipitation is one of the elements that is documented to be greatly affected by climate change. In its various forms, precipitation comprises the primary source of freshwater, which is vital for the sustainability of almost all human activities. Its socio-economic significance is fundamental in managing this natural resource effectively, in applications ranging from irrigation to industrial and household usage. Remote sensing of precipitation is pursued through a broad spectrum of continuously enriched and upgraded instrumentation, embracing sensors which can be ground-based (e.g., weather radars), satellite-borne (e.g., passive or active space-borne sensors), underwater (e.g., hydrophones), aerial, or ship-borne. This volume hosts original research contributions on several aspects of remote sensing of precipitation, including applications which embrace the use of remote sensing in tackling issues such as precipitation estimation, seasonal characteristics of precipitation and frequency analysis, assessment of satellite precipitation products, storm prediction, rain microphysics and microstructure, and the comparison of satellite and numerical weather prediction precipitation products.

Northern China --- raindrop size distribution (DSD) --- microphysical processes --- quantitative precipitation estimation (QPE) --- satellite-based precipitation --- elevation --- extreme events --- IMERG-V05B and V06A --- MSWEP --- ERA5 --- SM2RAIN --- precipitation estimation --- soil moisture --- SM2RAIN-CCI --- SM2RAIN-ASCAT --- multi-satellite precipitation analysis (TMPA) --- error decomposition --- complex topography --- diverse climate --- gauge data --- IMERG --- TAHMO --- morphing --- field displacement --- TIGGE --- precipitation --- numerical weather prediction --- satellite --- flood --- spring 2019 --- Iran --- GPM IMERG --- satellite precipitation --- spatiotemporal analysis --- statistical distribution --- validation --- Mainland China --- GSMaP_NRT --- GSMaP_Gauge_NRT --- raindrop size distribution --- radar reflectivity --- raindrop spectrometer --- semi-arid area --- assessment --- Taiwan --- data assimilation --- WRF model --- high-impact rainfall events --- GNSS ZTD --- optimum interpolation --- geographically weighted regression --- downscaling --- Tianshan Mountains --- satellite precipitation products --- evaluation --- daily rainfall --- hourly rainfall --- GPM --- TRMM --- GNSS --- GNSS antenna --- receiver antenna calibration --- relative calibration --- Phase Center Variation --- U-blox --- goGPS --- Zenith Tropospheric Delay --- ZED-F9P --- GSMaP --- Nepal --- cloud radar --- thunderstorm --- LDR --- hydrometeor --- hydrometeor classification --- lightning --- discharge --- remote sensing --- SEVIRI --- ground radar --- precipitation interpolation --- geographically and temporally weighted regression --- time weight function --- geographically and temporally weighted regression kriging --- extreme rainfall --- polarimetric radar signatures --- quantitative precipitation estimation --- southern china --- reanalysis --- linear trends --- mainland China --- EDBF algorithm --- geospatial predictor --- spatial pattern --- weighted precipitation --- Cyprus --- bias correction --- object-based method --- storm events --- Thies --- disdrometer --- weather circulations --- convective --- stratiform --- rain spectra --- radar reflectivity–rain rate relationship --- gridded precipitation products --- abrupt changes --- trends --- statistical indicators --- agriculture --- Pakistan --- rainfall --- radar --- extreme precipitation --- spatial bootstrap --- Louisiana --- annual maxima --- n/a --- radar reflectivity-rain rate relationship