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Meningitis --- Leptomeningitis --- Central nervous system --- Neisseria meningitidis --- Diagnosis. --- Complications. --- Diseases

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The development of a comprehensive vaccine against Neisseria meningitidis, the causative agent of meningococcal disease, has remained elusive because of bacterial diversity and immunologic evasion. In Meningococcal Vaccines: Methods and Protocols, Andrew Pollard and Martin Maiden have assembled an impressive collection of the latest molecular and cellular techniques for the development, evaluation, and implementation of vaccines to be used against this dreaded disease. The contributors-leading scientists, clinicians, and public health physicians-describe in detail the many approaches to vaccine design, as well as the assessment of immune response to vaccine candidates and novel vaccine formulations. They also present as a test case the recent implementation of a new meningococcal vaccine in the United Kingdom. A companion volume, Meningococcal Disease: Methods and Protocols, contains detailed methods for diagnostic microbiology, bacterial characterization, epidemiology, host-pathogen interactions, and clinical studies. Timely and comprehensive, Meningococcal Vaccines: Methods and Protocols provides the scientist, public health physician, epidemiologist, clinical microbiologist, and clinician with the essential tools to lay bare the secrets of the meningococcus and to develop, evaluate, and implement successful new meningococcal vaccines.

Bacterial vaccines --- Meningitis --- Neisseria meningitidis --- Meningococcus --- Neisseria --- Leptomeningitis --- Central nervous system --- Bacterins --- Vaccines --- Diseases --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases

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Describing more than two centuries of epidemic meningitis, In the Blink of an Eye introduces a deadly and frightening bacterial infection of the brain—one that afflicts healthy children and young adults in dramatic fashion, often changing or taking lives in just hours or days.  Meningococcal meningitis is the culprit—causing sporadic cases as well as explosive, unpredictable outbreaks of disease throughout the world—leading to the deaths of dozens to hundreds of thousands every year.  Beginning with the case of a healthy teenage boy who rapidly succumbs to the disease, the book traces meningitis through its various social contexts.  From the acceptance of the germ theory of disease and the birth of the sister sciences of microbiology and immunology in the nineteenth century to the modern molecular era, the story traverses more than 200 years of medical history.  It leads us through the early descriptions of the disease, its impact on military forces, large outbreaks of meningitis in Africa and elsewhere, and the evolution of approaches to its treatment, control, and prevention.  In so doing, we witness the development of modern medical research and education, the discovery of antibiotics, the rapid emergence of drug-resistant bacteria, the invention of a novel class of vaccines, and learn the inner workings of disease processes and the human immune system.  The story of meningococcal meningitis—winding through the evolution of infectious diseases, the great European capitals of nineteenth century science, the Rockefeller Institute, the dye industry, Nazi Germany, military medicine, the Vietnam era, and prospects for an end to epidemic disease—parallels the rise of modern medical science.

Meningitis -- Molecular aspects. --- Meningitis, Meningococcal -- Diagnosis. --- Meningitis. --- Neisseria meningitidis -- Laboratory manuals. --- Meningitis, Cerebrospinal --- Biological Products --- Meningococcal Infections --- Meningitis, Bacterial --- Neisseriaceae Infections --- Central Nervous System Bacterial Infections --- Complex Mixtures --- Meningitis --- Chemicals and Drugs --- Central Nervous System Infections --- Gram-Negative Bacterial Infections --- Bacterial Infections --- Central Nervous System Diseases --- Bacterial Infections and Mycoses --- Nervous System Diseases --- Diseases --- Vaccines --- Meningitis, Meningococcal --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Epidemics --- Leptomeningitis --- History. --- Medicine. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Central nervous system --- Neisseria meningitidis --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases

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This book tells the combined stories of how scientists across the 19th and 20th centuries defeated meningitis - not through flawless scientific research, but often through a series of serendipitous events, misplaced assumptions, and flawed conclusions. The result is a story of not just a vanquished disease, but how scientific accomplishment sometimes occurs where it's least expected.

Meningitis --- history --- Central Nervous System Diseases --- Méningite --- Système nerveux cenral --- Aspect historique. --- Maladies --- Système nerveux central --- History, 19th Century --- History, 20th Century --- History, 21st Century --- 21st Cent. History (Medicine) --- 21st Cent. History of Medicine --- 21st Cent. Medicine --- Historical Events, 21st Century --- History of Medicine, 21st Cent. --- History, Twenty-first Century --- Medical History, 21st Cent. --- Medicine, 21st Cent. --- 21st Century History --- 21st Cent. Histories (Medicine) --- 21st Cent. Medicines --- 21st Century Histories --- Cent. Histories, 21st (Medicine) --- Cent. History, 21st (Medicine) --- Cent. Medicine, 21st --- Cent. Medicines, 21st --- Century Histories, 21st --- Century Histories, Twenty-first --- Century History, 21st --- Century History, Twenty-first --- Histories, 21st Cent. (Medicine) --- Histories, 21st Century --- Histories, Twenty-first Century --- History, 21st Cent. (Medicine) --- History, Twenty first Century --- Medicines, 21st Cent. --- Twenty-first Century Histories --- Twenty-first Century History --- 20th Cent. History (Medicine) --- 20th Cent. History of Medicine --- 20th Cent. Medicine --- Historical Events, 20th Century --- History of Medicine, 20th Cent. --- History, Twentieth Century --- Medical History, 20th Cent. --- Medicine, 20th Cent. --- 20th Century History --- 20th Cent. Histories (Medicine) --- 20th Century Histories --- Cent. Histories, 20th (Medicine) --- Cent. History, 20th (Medicine) --- Century Histories, 20th --- Century Histories, Twentieth --- Century History, 20th --- Century History, Twentieth --- Histories, 20th Cent. (Medicine) --- Histories, 20th Century --- Histories, Twentieth Century --- History, 20th Cent. (Medicine) --- Twentieth Century Histories --- Twentieth Century History --- 19th Cent. History (Medicine) --- 19th Cent. History of Medicine --- 19th Cent. Medicine --- Historical Events, 19th Century --- History of Medicine, 19th Cent. --- History, Nineteenth Century --- Medical History, 19th Cent. --- Medicine, 19th Cent. --- 19th Century History --- 19th Cent. Histories (Medicine) --- 19th Century Histories --- Cent. Histories, 19th (Medicine) --- Cent. History, 19th (Medicine) --- Century Histories, 19th --- Century Histories, Nineteenth --- Century History, 19th --- Century History, Nineteenth --- Histories, 19th Cent. (Medicine) --- Histories, 19th Century --- Histories, Nineteenth Century --- History, 19th Cent. (Medicine) --- Nineteenth Century Histories --- Nineteenth Century History --- Leptomeningitis --- Central nervous system --- Neisseria meningitidis --- History --- Diseases --- Nervous System Diseases --- history.