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MODELISATION DU METABOLISME DE LA THYMIDINE EN VUE DE SON APPLICATION A L'ETUDE DE LA REGENERATION HEPATIQUE
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Year: 1987 Publisher: Louvain-la-Neuve: UCL,

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The one-third partial hepatectomy: a model to study various factors influencing the liver regeneration
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Year: 1994 Publisher: Bruxelles: UCL.,

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Our study clearly establishes that the one-third partial hepatectomy is of particular interest in the study of the regenerative response, as In contrast to the two-thirds partial hepatectomy, it can easily be amplified by various factors.
In the first part, infusion of Diprivan (Propofol) increases the DNA synthesis in 10% partial hepatectomy from control value 13.2+/-1.8 to 54.5+/-7.7 (P<0.01),in one-third partial hepatectomy from 41.5+/-3.1 to 102.7+/-11.5 (P<0.001), in sham operation from 7.2+/-1.7 to 23.1+/-3.4 (P<0.01) but not after a two-thirds partial hepatectomy. Infusion in Intralipid emulsion alone also increases the DNA synthesis in 10% partial hepatectomy from 13.2+/-1.8 to 24.3+/-2.0 (P<0.01), in one-third partial hepatectomy from 7.2+/-1.7 to 20.4+/-4.2 (P<0.5) but not in two-thirds partial hepatectomy.
In the second part, a stimulatory effect of HGF administration on the DNA synthesis after a one-third partial hepatectomy, is obtained by two injections, immediately and at 12 hours (from control value 41+/-3.1 to 143+/-27.2 (P<0.001), by continuous infusion during 24 hours (to 109+/-20 P<0.01) or by a single injection at the 10th hour (to 105+/-19.5 O<0.01). By contrast, the administration immediately after the one-third partial hepatectomy seems much less efficient (65+/-18.8).
In the third part, the conversion of one-third into a two-third partial hepatectomy obtains a 24-jour response identical to the one after classic two-thirds partial hepatectomy (315+/-24 versus 333+/-18). By contrast, when the conversion is delayed at 14 hours, this response is markedly reduced (50+/-13).
These results suggest that the one-third partial hepatectomy is an interesting model which is more sensitive and it is susceptible to be modified by various factors such a Diprivan, Intralipid. The magnitude of the regenerative response to a one-third partial hepatectomy is easily modified at around the 10th hour by the administration of HGF or by the further reduction of the liver mass.


Dissertation
Contribution à l'étude du contrôle de la prolifération cellulaire dans le foie de rat normal et précancéreux : analyse de la cinétique cellulaire
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Year: 1985 Publisher: Liège : Université de Liège. Faculté de médecine (ULg). Département de clinique et pathologie médicales,

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Hepatotrophic factors
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ISBN: 0444900187 9780444900180 Year: 1978 Publisher: Amsterdam: Elsevier,

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Hepatitis and chronic liver disease
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Year: 1996 Publisher: London : W.B. Saunders,

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Dissertation
Contribution à l'étude de la carcinogenèse chimique : effets précoces d'agents alkylants sur la biosynthèse de l'acide déoxyribonucléique dans le foie de rat en régénération
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Year: 1977 Publisher: [S. l.] : [chez l'auteur],

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FGF 15/19, rôle potentiel dans la régénération hépatique : revue de la littérature et expérience pilote
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Year: 2014 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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FGF19 (fibroblastes growth factor) and its murine homologue FGF15 are members of the subfamily of FGF19 with endocrine action. FGF15 and 19 have a similar expression pattern and they regulate glucose metabolism and bile acids (BA) in a similar way. FGF15/19 plays a cruciale role in the regulating the bile acid pool. Indeed, its expression is induced in the intestine by the acid receptor FXR (Farnesoid X Receptor). FGF15/19 is then released into the circulation and inhibits the expression of CYp7al (the rate-limiting enzyme in the classical pathway of BA synthesis) in the liver. Iker Uriarte et al. Pinpointed that FGF15 is a critical hormone in modulating the rate of BA during liver regeneration. Therefore, we questioned whether FGF15/19 could have an impact on the proliferation and differentiation of progenitor cells into hepatocytes and cholangiocytes. In order to assess this hypothesis we evaluated the effect of recombinant FGF19 (r FGF19) injections on progenitor cells in a murine model hepatotocixity. We exposed C57BL/6J mice to a choline-deficient, ethionine-supplemented diet (CDE) during 23 days to stimulate expansion of progenitor cells.During the last 11 days mice were injected with PBS or rFGF19.This preliminary experiment showed that: 1) rFGF19 injections are well tolerated, 2) the rFGF19 is active in mice, it is detected in treated mice’s serum (whereas it’s undetectable in control mice) and inhibits effectively the expression of Cyp7al in the liver. By using the localization in the CDE model we did not observe any evident effect produced by rFGF19: LPC seem to have a similar localization in the CDE mice treated with rFGF19 compared to thecontrols. Moreover, both mice groups present a comparable number of LPC. We could continue our study by analyzing the effects in a different mouse model (OPN-iCreERT2; Rosa26RYFP- that allows tracking the fate of progenitor cells, so as to evaluate the impact of FGF19 on the differentiation of progenitor cells in hepatocytes. Le FGF19 (facteur de croissance des fibroblastes – fibroblastes growth factor) ou son homologue murin, FGF15 sont membres de la sous famille du FGF19 à action endocrine. Les ARN messagers (ARNm) de FGF15 et FGF19 sont des profils d’expression similaires et régulent de la même façon le métabolisme du glucose et des acides biliaires. FGF15/ FGF19 joue un rôle important dans la régulation du pool des acides biliaires. En effet, son expression est induite dans l’intestin par le récepteur aux acides biliaires FXR (Farnesoid X Receptor). Il est alors relargué dans la circulation et va inhiber l’expression de CYp7al dans le foie, enzyme de synthèse des acides biliaires. Iker Uriarte et al. ont identifié FGF15 comme une hormone essentielle dans la modulation du taux de BA au cours de la régénération du foie. Nous proposons que le FGF15 pourrait influencer la prolifération et la différenciation des cellules progénitrices en hépatocytes et cholangiocytes. Pour évaluer cette question nous avons évalué l’effet de l’administration de FGF19 recombinant sur les cellules progénitrices dans un modèle murin d’hépatotoxicité. Nous avons exposé des souris C57BL6J à un régime déficient en choline supplémentée en éthionine (CDE), pendant 23 jours pour induire l’expansion des cellules progénitrices. Pendant les 11 derniers jours, les souris ont été injectées avec du rFGF19 humain ou du PBS. Cette expérience préliminaire a permis de montrer que 1) les injections de rFGF19 sont bien tolérées, 2) que le rFGF19 est fonctionnel chez la souris : il est détecté dans le sérum des souris traitées (indétectables dans les souris contrôles) et inhibe bien l’expression de Cyp7al dans le foie. Dans un modèle d’induction des cellules progénitrices, nous n’avons pas observé d’effet évident du rFGF19 : les LPC semblent aussi nombreuses et ont une localisation similaire chez les souris CDE traitées au rFGF19 ou non. On pourrait continuer notre étude en allant à analyser la réponse de modèle des souris différents (OPN-IcreERT2 ; Rosa26RYFP) qui permet de suivre le devenir des cellules progénitrices, et ainsi d’évaluer l’effet de FGF19 sur la différenciation des cellules pro génitrices en hépatocytes.


Dissertation
Experimental and clinical studies on the effect of liver regeneration on tumor growth
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Year: 2000 Publisher: Groningen Regenboog

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Dissertation
Influence des corticoïdes dans la régulation nycthémérale de la prolifération hépatique chez le rat
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Year: 1983 Publisher: Liège : Université de Liège, Faculté des sciences (ULg),


Dissertation
Climbing the stairway to hepatic gene therapy : strategies for efficient gene transfer to the liver

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