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Book
A retrospective study of luteal phase support exclusively by a continuous Low-Dose GnRH Agonist in ART treatment
Authors: --- --- ---
Year: 2017 Publisher: Bruxelles: UCL. Faculté de médecine et de médecine dentaire,

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BACKGROUN D ln IVF cycles, an iatrogenic luteal phase deficiency is observed. To counter its harmful effects, a proper luteal phase support (LPS) has to be provided. Classically, progesterone would be used for this purpose. However, in antagonist protocols, another option should be considered: the use of only a GnRH agonist to support the luteal phase. The aim of this dissertation is to evaluate the efficacy of an exclusive use of Buserelin for LPS and to seek out possible negative effects on the infants born with this protocol. METHODS This is a retrospective study. A database was established, consisting of information on every transfer executed in Cliniques Universitaires Saint-Luc (CUSL) from 2010 up to 2013 in which patients only received intranasal buserelin for luteal phase support ( here after called BP or Buserelin Population). This information has been analyzed and compared with that of the Global Population (GP) and/or Non Buserelin Population (NBP) of patients in the Saint-Luc database undergoing an IVF/ICSl-treatment with a fresh embryo transfer in the corresponding years. RESULTS ln the BP, 481 transfers was executed of which 158 resulted in pregnancy and 113 infants were born, including 9 pairs of twins. A comparison of patient demographics of both groups, shows that women of the BP are significantly eider (35.2 ± 0.5 vs. 34.4 ± 0.15) and have a higher range (2.96 ± 0.16 vs. 1.45 ± 0.022) than those of the GP. A tendency towards higher early pregnancy rates was observed (31.0% in BP vs. 26.2% in NBP), but this was net statistically significant. Eleven ectopie pregnancies occurred in the BP, which is significantly (P < 0.01) more than in the NBP (7.0% in BP vs. 2.6% in NBP). Women presenting early pregnancy failure were generally more advanced in age; no other common patient characteristics were detected. Miner malformations were observed in 2 infants, which represents a total of l.77% of the children and is net higher than in the global population. Considering the low number of subjects included in this study, conclusions should be drawn with caution. By use of the Poisson distribution, a confidence interval was established (with a confidence level o f 95%) situating the true number of malformations between 0.32% and 5.7% when only Buserelin is used for LPS.CONCLUSION When only intranasal Buserelin was used to support the luteal phase, a tendency towards more early pregnancy failure and a significantly higher number of ectopic pregnancies were observed. No increased occurrence of malformations was found. OBJECTIF Dans les cycles de FIV, une insuffisance iatrogène de la phase lutéale est observée. Pour contrer ses effets délétères, un bon support de la phase lutéale doit être fourni. Classiquement, ceci est réalisé par de la progestérone. Par contre, dans les protocoles antagonistes, une autre option doit être considérée: l'utilisation d'un GnRH agoniste seul pour renforcer la phase lutéale. Le but de ce mémoire est d'évaluer l'efficacité de l'utilisation de Busereline dans cette optique et de rechercher d'éventuels effets négatifs sur les enfants nés dans le cadre de ce protocole. METHODES Il s'agit d'une étude rétrospective. Une base de données a été constituée, reprenant des informations sur chaque transfert effectué aux Cliniques Universitaires Saint-Luc (CUSL) de 2010 à 2013 inclus, où les patientes n'ont reçu que le Busereline intranasal seul pour renforcer la phase lutéale (BP : Buserelin Population). Ces données ont été analysées et comparées avec celles de la population générale (GP) et/ou de la population non busereline (NBP) des CUSL subissant un traitement par FIV/ICSI avec un transfert d'embryons frais dans les années correspondantes. RESULTATS Dans la BP, 481 transferts sont documentés, dont 158 ont mené à une grossesse et 113 enfants sont nés, parmi lesquels 9 paires de jumeaux. Une comparaison des caractéristiques démographiques des patientes des deux groupes démontre que les femmes de la BP sont considérablement plus âgées (35,2 ± 0,5 vs. 34,4 ± 0,15) et présentent un rang plus élevé(2,96 ± 0,16 vs. 1,45 ± 0,022) que celles de la GP. Une tendance vers plus d'échecs de grossesse précoces a été observée (31,0% pour la BP vs. 26,2% pour la NBP), mais ceci n'était pas statistiquement significatif. Onze grossesses extra -utérines ont été rapportées, ce qui est significativement plus (P < 0,01) que dans la NBP (7,0% dans la BP vs. 2,6% dans la NBP). Les patientes présentant un échec de grossesse précoce étaient généralement plus âgées ; aucune autre caractéristique commune aux patientes n'a pu être mise en évidence. Des malformations mineures ont été observées chez 2 enfants, ce qui représente 1,77% des nouveau-nés et n'est pas plus élevé que dans la population globale. Vu le petit nombre de sujets inclus dans cette étude, ces conclusions doivent être tirées avec prudence. Un intervalle de confiance (avec un niveau de confiance de 95%) a été établi avec l'utilisation de la distribution de Poisson. Celui-ci situe l'incidence réelle de malformations entre 0,32% et 5,7% quand le Busereline seul est employé pour renforcer la phase lutéale.


Book
Reproductive endocrinology
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Year: 1992 Publisher: London : W.B. Saunders,

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Ovulation induction : the difficult patient
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ISBN: 070201754X Year: 1993 Publisher: London : Baillière-Tindall,

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Book
Das Prämenstruelle Syndrom (PMS) natürlich behandeln
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ISBN: 9783842683969 3842683960 9783899936292 Year: 2012 Publisher: Hannover Schlütersche

Curing PMS naturally with Chinese medicine
Author:
ISBN: 0585138397 9780585138398 0936185856 9780936185859 Year: 1997 Publisher: [Place of publication not identified] Blue Poppy Press

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Keywords

Premenstrual syndrome --- Medicine, Chinese --- Medicine, East Asian Traditional --- Menstruation Disturbances --- Medicine, Traditional --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Culture --- Complementary Therapies --- Anthropology, Cultural --- Diseases --- Therapeutics --- Anthropology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Social Sciences --- Anthropology, Education, Sociology and Social Phenomena --- Medicine, Chinese Traditional --- Premenstrual Syndrome --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Premenstrual Tension --- Premenstrual Syndromes --- Premenstrual Tensions --- Syndrome, Premenstrual --- Syndromes, Premenstrual --- Tension, Premenstrual --- Tensions, Premenstrual --- Menstruation --- Chinese Traditional Medicine --- Traditional Chinese Medicine --- Traditional Tongue Assessment --- Traditional Tongue Diagnosis --- Chinese Medicine, Traditional --- Chung I Hsueh --- Traditional Medicine, Chinese --- Zhong Yi Xue --- Hsueh, Chung I --- Tongue Assessment, Traditional --- Tongue Diagnoses, Traditional --- Tongue Diagnosis, Traditional --- Traditional Tongue Assessments --- Traditional Tongue Diagnoses --- Acupuncture Therapy --- Medicine, Kampo --- Science, Social --- Sciences, Social --- Social Science --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Cultural Anthropology --- Material Culture --- Ethnography --- Culture, Material --- Ethnographies --- Material Cultures --- Qualitative Research --- Alternative Therapies --- Therapy, Alternative --- Therapy, Complementary --- Alternative Medicine --- Complementary Medicine --- Medicine, Alternative --- Medicine, Complementary --- Therapies, Alternative --- Therapies, Complementary --- Beliefs --- Cultural Background --- Cultural Relativism --- Customs --- Background, Cultural --- Backgrounds, Cultural --- Belief --- Cultural Backgrounds --- Cultural Relativisms --- Cultures --- Relativism, Cultural --- Relativisms, Cultural --- Symptoms and General Pathology --- Pathological Processes --- Processes, Pathologic --- Processes, Pathological --- Indigenous Medicine --- Primitive Medicine --- Traditional Medicine --- Ethnomedicine --- Folk Medicine --- Folk Remedies --- Home Remedies --- Medicine, Folk --- Medicine, Indigenous --- Medicine, Primitive --- Folk Remedy --- Home Remedy --- Remedies, Folk --- Remedies, Home --- Remedy, Folk --- Remedy, Home --- Traditional Pulse Diagnosis --- Materia Medica --- Nostrums --- Pharmacognosy --- Plants, Medicinal --- Ethnopharmacology --- Irregular Menses --- Irregular Menstruation --- Menstrual Irregularities --- Menstrual Irregularity --- Hypomenorrhea --- Menstruation Disorders --- Menstruation, Retrograde --- Polymenorrhea --- Disorder, Menstruation --- Disorders, Menstruation --- Disturbance, Menstruation --- Disturbances, Menstruation --- Irregularity, Menstrual --- Menses, Irregular --- Menstruation Disorder --- Menstruation Disturbance --- Menstruation, Irregular --- Retrograde Menstruation --- East Asian Medicine --- East Asian Traditional Medicine --- Medicine, East Asia --- Medicine, Far East --- Medicine, Oriental --- Medicine, Oriental Traditional --- Medicine, Traditional, East Asia --- Oriental Medicine --- Oriental Medicine, Traditional --- Oriental Traditional Medicine --- Traditional East Asian Medicine --- Traditional Far Eastern Medicine --- Traditional Medicine, Oriental --- Traditional Medicine, East Asia --- Asia Medicines, East --- East Asia Medicine --- East Asia Medicines --- East Asian Medicines --- East Medicine, Far --- East Medicines, Far --- Far East Medicine --- Far East Medicines --- Medicine, East Asian --- Medicine, Traditional Oriental --- Medicines, East Asia --- Medicines, Far East --- Traditional Oriental Medicine --- Traditional Oriental Medicines --- Chinese medicine --- TCM (Medicine) --- Traditional Chinese medicine --- Traditional medicine --- Late luteal phase dysphoric disorder --- LLPDD (Gynecology) --- PMDD (Gynecology) --- PMS (Gynecology) --- Pre-menstrual syndrome --- Premenstrual dysphoria --- Premenstrual dysphoric disorder --- Premenstrual tension --- Menstruation disorders --- Syndromes --- therapy --- Traditional Medicine Practitioners

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