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This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Biomechanics. --- Cell physiological phenomena. --- Cells -- Mechanical properties -- Mathematical models. --- Cells -- Mechanical properties. --- Biophysical Processes --- Signal Transduction --- Engineering --- Health Occupations --- Phenomena and Processes --- Models, Theoretical --- Disciplines and Occupations --- Biochemical Processes --- Technology, Industry, and Agriculture --- Cell Physiological Processes --- Investigative Techniques --- Physical Processes --- Biophysical Phenomena --- Biochemical Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physical Phenomena --- Chemical Processes --- Technology, Industry, Agriculture --- Biomedical Engineering --- Mechanotransduction, Cellular --- Models, Biological --- Cell Physiological Phenomena --- Chemical Phenomena --- Health & Biological Sciences --- Biomedical engineering. --- Cytology. --- Engineering. --- Construction --- Cell biology --- Cellular biology --- Clinical engineering --- Medical engineering --- Cell biology. --- Biomedical Engineering. --- Cell Biology. --- Industrial arts --- Technology --- Bioengineering --- Biophysics --- Medicine --- Biology --- Cells --- Cytologists --- Biomedical Engineering and Bioengineering.

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Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource

Pharmaceutical chemistry --- Drugs --- Chimie pharmaceutique --- Médicaments --- Design --- Conception --- Pharmaceutical chemistry. --- Chimie pharmaceutique (Trad. du MeSH) --- Modèles chimiques (Trad. du MeSH) --- Chimie pharmaceutique. --- Pharmaceutical Preparations --- Design. --- Conception. --- chemistry. (MeSH - aucune traduction) --- Chemical models. --- Drugs. --- Pharmaceutical Preparations. --- Chemistry, Pharmaceutical --- Models, Chemical --- Chemistry --- Models, Theoretical --- Pharmacology --- Chemicals and Drugs --- Investigative Techniques --- Biological Science Disciplines --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Médicaments --- Drug design --- Pharmaceutical design --- Drug development --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Cellular signal transduction. --- Mechanotransduction, Cellular --- Cellular Mechanotransduction --- Mechanosensory Transduction --- Signal Transduction, Mechanical --- Mechanical Signal Transduction --- Transduction, Mechanosensory --- Podosomes --- Mechanoreceptors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Signal Transduction. --- Transduction du signal cellulaire --- Cellular signal transduction --- ELSEVIER-B EPUB-LIV-FT --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- chemistry

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This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.

Cytokines. --- Tissues -- Mechanical properties. --- Cytokines --- Intercellular Signaling Peptides and Proteins --- Biophysical Processes --- Signal Transduction --- Cell Physiological Processes --- Proteins --- Peptides --- Biochemical Processes --- Biophysical Phenomena --- Biological Factors --- Physical Processes --- Amino Acids, Peptides, and Proteins --- Biochemical Phenomena --- Chemicals and Drugs --- Chemical Processes --- Physical Phenomena --- Cell Physiological Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Mechanotransduction, Cellular --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Cytology --- Stretch (Physiology) --- Stretching (Physiology) --- Life sciences. --- Human physiology. --- Immunology. --- Molecular biology. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Biomedicine general. --- Human Physiology. --- Molecular Medicine. --- Biomechanics --- Elastic tissue --- Cellular immunity --- Immune response --- Regulation --- Cytology. --- Medicine. --- Immunobiology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Health Workforce --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It  contains a detailed description of several  stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of  nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii  cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume  highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.  This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Cells -- Mechanical properties. --- Tissues -- Mechanical properties. --- Transduction. --- Sensory Receptor Cells --- Membrane Glycoproteins --- Membrane Transport Proteins --- Biophysical Processes --- Signal Transduction --- Biochemical Processes --- Biophysical Phenomena --- Carrier Proteins --- Neurons, Afferent --- Physical Processes --- Membrane Proteins --- Cell Physiological Processes --- Peripheral Nervous System --- Ion Channels --- Mechanotransduction, Cellular --- Mechanoreceptors --- Physical Phenomena --- Proteins --- Nervous System --- Chemical Processes --- Neurons --- Cell Physiological Phenomena --- Biochemical Phenomena --- Anatomy --- Amino Acids, Peptides, and Proteins --- Chemical Phenomena --- Cells --- Phenomena and Processes --- Chemicals and Drugs --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Cytology --- Mechanoreceptors. --- Genetic transduction --- Mechanicoreceptors --- Life sciences. --- Human physiology. --- Cardiology. --- Medical biochemistry. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Medical Biochemistry. --- Human Physiology. --- Microbial genetics --- Bacteriophages --- Sensory receptors --- Cytology. --- Biochemistry. --- Heart --- Internal medicine --- Human biology --- Medical sciences --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Cell biology --- Cellular biology --- Cytologists --- Diseases --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology

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Animal psychology and neurophysiology --- Mechanoreceptors --- Sensory Receptor Cell --- Thermoreceptors --- Mechanoreceptors. --- Sensory Receptor Cells. --- Thermoreceptors. --- Thermoreceptor --- Neural Receptors --- Receptors, Sensory --- Sensory Neurons --- Sensory Receptors --- Nerve Endings, Sensory --- Neurons, Sensory --- Neuroreceptors --- Receptors, Neural --- Nerve Ending, Sensory --- Neural Receptor --- Neuron, Sensory --- Neuroreceptor --- Receptor Cell, Sensory --- Receptor Cells, Sensory --- Receptor, Neural --- Receptor, Sensory --- Sensory Nerve Ending --- Sensory Nerve Endings --- Sensory Neuron --- Sensory Receptor --- Neurons, Afferent --- Sense Organs --- Mechanoreceptor Cells --- Golgi Tendon Organs --- Krause's End Bulbs --- Meissner's Corpuscle --- Neurotendinous Spindles --- Receptors, Stretch --- Ruffini's Corpuscles --- Stretch Receptors --- Bulbs, Krause's End --- Cell, Mechanoreceptor --- Cells, Mechanoreceptor --- Corpuscle, Meissner's --- Corpuscles, Ruffini's --- End Bulbs, Krause's --- Krause End Bulbs --- Krauses End Bulbs --- Mechanoreceptor --- Mechanoreceptor Cell --- Meissner Corpuscle --- Meissners Corpuscle --- Neurotendinous Spindle --- Organs, Golgi Tendon --- Receptor, Stretch --- Ruffini Corpuscles --- Ruffinis Corpuscles --- Spindle, Neurotendinous --- Spindles, Neurotendinous --- Stretch Receptor --- Tendon Organs, Golgi --- Mechanotransduction, Cellular --- Sensilla --- Golgi Tendon Organ --- Krause's End Bulb --- Ruffini's Corpuscle --- Bulb, Krause's End --- Corpuscle, Ruffini's --- End Bulb, Krause's --- Krause End Bulb --- Krauses End Bulb --- Organ, Golgi Tendon --- Ruffini Corpuscle --- Ruffinis Corpuscle --- Tendon Organ, Golgi --- Sensory Receptor Cells