Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Medicine, African Traditional --- Ethnopsychology --- Mental Disorders --- Anthropology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This thesis describes the steps taken to assess the efficacy and safety of "Extract P", a mixture f 10 médicinal plants sold in Sénégal as traditional antimalarial medicine, which has never been subject to a scientific study. The 10 plants are Cassia occidentalis, Momordica Charantia Azadirachta indica, Mitracarpus scaber, Citrus limon, Hoslundia opposita, Centella asiatica. Tamarindus indica, Phyllantus amarus and Phyllantus reticulatus. As the protocol for a clinical follow-up study was rejected by the Ethics Committee of Sénégal in July 2013, a study of subchronic toxicity of "Extract P" was conducted. The aim was to gather more information conceming this traditional treatment with a view to complément the interest of its clinical evaluation. Methodology: We studied the subchronic toxicity of "Extract P" following the oral route of treatment administration to local breed rabbits in Burkina Faso. For this purpose, 2 batches of local breed rabbits were used : control batch: treated with distilled water, solvent dilution of the extract. - Test batch: treated with "Extract P" at a dose équivalent to 10 times the normal curative administration. Extract P" was administered to the rabbits orally for 28 days twice daily (morning and evening). Blood samples were taken from the marginal vein of the ear on days 0, 3, 7, 14 and 28 for each lot. Day 0 corresponded to the évaluation of basic parameters in ail lots without drug administration. Every rabbit of the test batch was given for 28 days a total daily dose of 0.75 ml of "Extract P", calculated for a rabbit of 1.5 kg. Biochemical and haematological parameters of the rabbits were determined before the study and during the entire length of the study. Results : Amongst the most relevant results, we wish to mention the following: concerning the effect of "Extract P" on the rabbits* weight: Although the weight of every batch of rabbits tended to increase, the variation was not significant between batches. This suggests that the administration of "Extract P" appears not to affect the animal weight significantly.This thesis describes the steps taken to assess the efficacy and safety of "Extract P", a mixture f 10 médicinal plants sold in Senegal as traditional antimalarial medicine, which has never been subject to a scientific study. The 10 plants are Cassia occidentalis, Momordica Charantia Azadirachta indica, Mitracarpus scaber, Citrus limon, Hoslundia opposita, Centella asiatica. Tamarindus indica, Phyllantus amarus and Phyllantus reticulatus. As the protocol for a clinical follow-up study was rejected by the Ethics Committee of Sénégal in July 2013, a study of subchronic toxicity of "Extract P" was conducted. The aim was to gather more information conceming this traditional treatment with a view to complément the interest of its clinical évaluation. Methodology : We studied the subchronic toxicity of "Extract P" following the oral route of treatment administration to local breed rabbits in Burkina Faso. For this purpose, 2 batches of local breed rabbits were used: - Control batch: treated with distilled water, solvent dilution of the extract. - Test batch: treated with "Extract P" at a dose équivalent to 10 times the normal curative administration."Extract P" was administered to the rabbits orally for 28 days twice daily (morning and evening). Blood samples were taken from the marginal vein of the ear on days 0, 3, 7, 14 and 28 for each lot. Day 0 corresponded to the évaluation of basic parameters in ail lots without drug administration. Every rabbit of the test batch was given for 28 days a total daily dose of 0.75 ml of "Extract P", calculated for a rabbit of 1.5 kg. Biochemical and haematological parameters of the rabbits were determined before the study and during the entire length of the study. Results: Amongst the most relevant results, we wish to mention the following: concerning the effect of "Extract P" on the rabbits* weight: although the weight of every batch of rabbits tended to increase, the variation was not significant between batches. This suggests that the administration of "Extract P" appears not to affect the animal weight significantly. Concerning the effect of "Extract P" on the rabbits' haematological parameters: In view of the restuls, it would appear that "Extract P" nas no significant effect on either white biood cells or red blood cells in comparison with Controls (p > 0.05). The results of the complété blood count suggest a good biological tolérance of "Extract P" in rabbits. as observed up to 28 days administration. Indeed, the various hematological parameters analyzed remained on the whole unchanged during the treatment period. Concerning the effect of "Extract P" on the rabbits’ blood biochemical parameters : The results indicate that the various biochemical parameters analyzed are minimally disturbed by the administration of "Extract P" and that the latter may act favourably on cholestérol by increasing blood levels of HDL cholestérol. Conclusion : the "Extract P" of the Traditional Hospital of Keur Massar was assessed by administrating it for 28 days to local breed rabbits, in order to evaluate its subchronic effects on vital functions such as blood count, liver and kidney function tests, blood glucose and lipids. The results obtained allow us to conclude that "Extract P" is well tolerated and has a possible bénéficiai effect on the synthesis of HDL or the 'good' cholestérol. This assessment of the subchronic toxicity of "Extract P" is part of a development strategy of African anti-malarial herbal medicines, according to the current guidelines of the WHO.

Medicine, African Traditional --- Phytotherapy --- Malaria --- Malaria --- Clinical Trials as Topic

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This subtle and powerful ethnography examines African healing and its relationship to medical science. Stacey A. Langwick investigates the practices of healers in Tanzania who confront the most intractable illnesses in the region, including AIDS and malaria. She reveals how healers generate new therapies and shape the bodies of their patients as they address devils and parasites, anti-witchcraft medicine, and child immunization. Transcending the dualisms between tradition and science, culture and nature, belief and knowledge, Langwick tells a new story about the materiality of healing and p

Anthropology, Cultural --- Medicine, African Traditional --- Medical care --- Traditional medicine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Traditional medicine --- Healing --- Medical policy --- Médecine traditionnelle --- Guérison --- Politique sanitaire --- Medicine, African Traditional --- Health Policy --- Curing (Medicine) --- Therapeutics --- Médecine traditionnelle --- Guérison

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

#SBIB:39A73 --- #SBIB:39A9 --- Etnografie: Afrika --- Medische antropologie / gezondheid / handicaps --- Afrique occidentale --- Ethnobotany --- Ethnopharmacology --- Mali --- Medicine, african traditional --- Phytotherapy --- Plants, medicinal --- Trees