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Physique mathematique --- Thermodynamique irreversible --- Modeles biologiques

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"Physiologically based pharmacokinetic modeling (PBPK) is an emerging field with increasing importance in drug discovery and development. It has become a common tool for most pharmaceutical scientists. This is the only book of its kind to serve the rapidly growing PBPK user community, developing principles from basics in clear, concise language. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. The new edition provides stronger emphasis on applications and relevant case studies, along with a companion website with datasets, covering many key developments in the field of PBPK modelling and simulations since the first edition's publication in 2012. In addition to revised chapters and improved figures and tables, the author adds a chapter on model-informed drug development and an entire 3rd section of case studies in different application areas to facilitate use in courses or development workshops"--

Pharmacokinetics. --- Drug Design. --- Models, Biological. --- Pharmacocinétique --- Conception de médicament --- Modèles biologiques --- Pharmacocinétique --- Conception de médicament --- Modèles biologiques

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Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches. --Provided by publisher.

Models, Biological. --- Systems Biology. --- Metabolic Networks and Pathways --- Biologie systémique --- Modèles biologiques --- physiology. --- Systems biology. --- Biological models. --- Systems Biology --- Models, Biological --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Biology, Systems --- Systems Theory --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- physiology --- Biologie systémique. --- Modèles biologiques. --- Systems biology --- Biological models

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Biological models --- Biological products --- Biological reagents --- Biologische modellen --- Biologische producten --- Biologische reagentia --- Bioproducten --- Bioproducts --- Modeles biologiques --- Models [Biological ] --- Producten [Biologische ] --- Products [Biological ] --- Produits biologiques --- Reagents [Biological ] --- Réactifs biologiques --- Biological Products --- 57.081 --- standards. --- BIOLOGICAL PRODUCTS --- standards --- Standards.

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Behavior --- Biological models --- Biologische modellen --- Emotional stress --- Gedrag --- Mental stress --- Modeles biologiques --- Models [Biological ] --- Moeurs et comportement --- Physiological stress --- Psychological stress --- Stress (Fysiologie) --- Stress (Physiologie) --- Stress (Physiology) --- Stress (Psychologie) --- Stress (Psychology) --- Stress -- Aspects psychologiques --- Stress [Psychological ] --- Stress [Psychologische ] --- Stress psychologique --- Stress émotionnel --- Tension (Physiology) --- Tension (Psychology) --- Tension mentale --- Stress