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This book contains the expert knowledge base of the field’s most experienced practitioners in the field of extradural bone and soft tissue malignancy. Chapters include modern classification, advanced anatomy, imaging, and the concepts around a multidisciplinary approach. Since treating primary tumors requires very different strategies than those used in metastatic tumors, the book devotes separate sections to each sub-discipline. For primary tumors, the text covers both benign and malignant entities and addresses unique anatomic zones such as the sacrum and skull base which require special technical expertise. For metastatic disease, the authors address the ever-important concept of prognosis, and discuss how to answer the eternal question: “How much should we do, and for whom?”. Chapters also explore the state of the art of treatment for the “big 5” histologies (renal cell, lung, breast, prostate, thyroid), with a special chapter emphasis on separation surgery and the now-standard combinatorial care between radiation and surgery. In addition, an entire section is dedicated to evolving surgical technology, which covers the use of minimally invasive techniques, navigation, robotics, 3D-printing, and other evolving technologies for spine tumor care. Infrequently-considered topics, such as how to evaluate a lesion which may be a tumor-mimic, and how to think about economic value in spine tumor surgery, are also presented. Surgical Spinal Oncology serves to help surgeons approach difficult clinical scenarios with a thoughtful, collaborative approach that leverages the best technology and thinking the field of spine oncology has to offer.

Neurosurgery. --- Surgical oncology. --- Orthopedics. --- Surgical Oncology. --- Surgical Orthopedics. --- Orthopaedics --- Orthopedia --- Surgery --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Nerves --- Neurosurgery --- Excision --- Treatment --- Spine --- Cancer. --- Cirurgia oncològica --- Medul·la espinal --- Esquena --- Sistema nerviós central --- Líquid cefalorraquidi --- Neurones motores --- Lesions medul·lars --- Mielitis --- Cirurgia del càncer --- Extirpació del càncer --- Oncologia quirúrgica --- Cirurgia --- Càncer

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This volume explores multiple methods and approaches used to generate human brain and neuroretinal organoids to address fundamental questions in human brain research. The chapters in this book cover topics such as self-organizing brain organoids with ventricles amenable to injection and electroporation; visualization of 3D organoids though the latest advancements in microscopy; generation of 3D retinal tissue with physiologically competent, light-sensitive photoreceptors; modeling brain tumors using genetically edited brain organoids; and brain organoids as a model to study Zika virus and SARS-CoV-2 infections. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Brain Organoid Research is a valuable resource for researchers at various levels of learning, ranging from undergraduate students, early researchers, and advanced laboratories. This book aims to be instrumental in moving this developing field forward.

Neurosciences. --- Neuroscience. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cervell --- Enginyeria de teixits --- Cèl·lules mare --- Cèl·lules --- Cèl·lules mare embrionàries --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina regenerativa --- Cap --- Craniologia --- Encèfal --- Sistema nerviós central --- Bulb raquidi --- Cerebel --- Escorça cerebral --- Evolució del cervell --- Frenologia --- Hipòfisi --- Líquid cefalorraquidi --- Memòria --- Neurones motores --- Neuropsicologia --- Neuropsiquiatria --- Psicologia --- Sistema límbic --- Somnis --- Son --- Tàlem (Anatomia) --- Tronc de l'encèfal --- Cirurgia cerebral

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This volume expands on the previous edition with a more extensive look at molecular motors and their roles in muscle contractions, vesicle transport, flagellar beating, chromosome segregation, and DNA replication and repair. The chapters in this book are divided into three parts: Part One looks at membrane motors, such as the bacterial flagellar rotary motor; Part Two discusses cytoskeletal motors, such as kinesin and myosin; and Part Three talks about nucleic acid motors, such as DNA polymerases, helicases, and nucleosome remodelers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Molecular Motors: Methods and Protocols, Second Edition is a valuable resource for (bio)physicists and molecular/cellular biologists whose research delves into the mechanisms at work in cells and the motors which power them.

Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neurones motores --- Biologia molecular --- Manuals de laboratori --- Protocols clínics --- Plans d'actuació mèdica --- Protocols en medicina --- Protocols de diagnòstic clínic --- Protocols mèdics --- Protocols terapèutics --- Medicina clínica --- Històries clíniques --- Protocols d'infermeria --- Tècniques de laboratori --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Motoneurones --- Cèl·lules --- Cervell --- Medul·la espinal --- Neurones

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Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.

Neurosciences. --- Neurology . --- Human anatomy. --- Neurology. --- Anatomy. --- Anatomy, Human --- Anatomy --- Human biology --- Medical sciences --- Human body --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Diseases --- Neuroanatomia --- Circuit neuronal --- Cervell --- Cap --- Craniologia --- Encèfal --- Sistema nerviós central --- Bulb raquidi --- Cerebel --- Escorça cerebral --- Evolució del cervell --- Frenologia --- Hipòfisi --- Líquid cefalorraquidi --- Memòria --- Neurones motores --- Neuropsicologia --- Neuropsiquiatria --- Psicologia --- Sistema límbic --- Somnis --- Son --- Tàlem (Anatomia) --- Tronc de l'encèfal --- Cirurgia cerebral --- Circuit nerviós --- Circuit neural --- Electrofisiologia --- Sistema nerviós --- Sinapsi --- Reflexos (Fisiologia) --- Xarxes neuronals (Neurobiologia) --- Anatomia del sistema nerviós --- Anatomia --- Neurobiologia --- Neurociències --- Central nervous system --- Neuroanatomy. --- Diseases.

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This volume explores the techniques used to study human and animal pericytes. Chapters in this volume cover a range of topics such as pericyte dissociation from tissues, and analysis by immunohistochemistry and flow cytometry; avian chimaeras to investigate the embryonic development of cell lineage; pericyte purification by fluorescence activated cell sorting and ensuing culture; tissue turnover and regeneration; and the dynamic study of pericyte involvement in cancer dissemination, in situ, and in culture. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Pericytes: Methods and Protocols is a valuable resource that helps researchers define the biologic identity, functions, and potentials of a cell lineage of increasing interest and therapeutic significance. .

Cèl·lules --- Sistema cardiovascular --- Aparell cardiovascular --- Aparell circulatori --- Sistema circulatori --- Sistema vascular --- Artèries --- Cor --- Sistema vasomotor --- Vasos sanguinis --- Circulació sanguínia --- Biologia --- Fisiologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules canceroses --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia) --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Biologia cel·lular --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules animals