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Mosaic Viruses --- RNA Replicase --- Zinc --- RNA Nucleotidyltransferases --- enzymology --- immunology --- pharmacology --- isolation & purification

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This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analys

Catalytic RNA. --- RNA Helicases. --- RNA Nucleotidyltransferases --- RNA --- Nucleotidyltransferases --- Nucleic Acids --- Phosphotransferases --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Transferases --- Enzymes --- Enzymes and Coenzymes --- RNA, Messenger --- RNA Helicases --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Messenger RNA --- Physiological transport. --- Metabolism. --- analysis. --- Catalytic rna. --- Messenger rna --- Rna helicases --- Analysis. --- Ribonucleic acid enzymes --- Ribozymes --- RNA enzymes --- Non-coding RNA --- Nucleases

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DNA-Directed DNA Polymerase --- DNA-Directed RNA Polymerases --- Enzyme Inhibitors. --- Antibiotics --- -DNA polymerases --- -RNA polymerases --- -DNA-dependent RNA polymerases --- DNA-directed RNA polymerases --- Polymerases, RNA --- Ribonucleate nucleotidyltransferases --- RNA nucleotidyltransferases --- Transferases --- Deoxyribonucleate nucleotidyltransferases --- DNA-dependent DNA polymerases --- DNA-directed DNA polymerases --- DNA nucleotidyltransferases --- Nucleotidyltransferases, Deoxyribonucleate --- Polymerases, DNA --- Zinc enzymes --- Polymerase chain reaction --- Anti-infective agents --- Microbial metabolites --- Allelopathic agents --- Antibiosis --- Pharmaceutical microbiology --- Phytoncides --- Inhibitors, Enzyme --- Enzymes --- Sulfhydryl Reagents --- antagonists & inhibitors. --- Physiological effect --- -Congresses --- Inhibitors --- antagonists & inhibitors --- -antagonists & inhibitors. --- DNA polymerases --- RNA polymerases --- Congresses. --- Enzyme Inhibitors --- DNA-dependent RNA polymerases --- Physiological effect&delete& --- Congresses --- Inhibitors&delete& --- Enzyme Inhibitor --- Inhibitor, Enzyme --- DNA Polymerase Inhibitors --- Inhibitors, DNA Synthesis --- Inhibitors, Nucleic Acid Synthesis --- Inhibitors, RNA Synthesis --- DNA Polymerase Inhibitor --- DNA Synthesis Inhibitor --- DNA Synthesis Inhibitors --- Nucleic Acid Synthesis Inhibitor --- RNA Synthesis Inhibitor --- RNA Synthesis Inhibitors --- Inhibitor, DNA Polymerase --- Inhibitor, DNA Synthesis --- Inhibitor, RNA Synthesis --- Inhibitors, DNA Polymerase --- Polymerase Inhibitor, DNA --- Polymerase Inhibitors, DNA --- Synthesis Inhibitor, DNA --- Synthesis Inhibitor, RNA --- Synthesis Inhibitors, DNA --- Synthesis Inhibitors, RNA --- DNA --- RNA --- ENZYME INHIBITORS --- CHEMICAL SYNTHESIS

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The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universität Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.  .

Engineering. --- Biomedical Engineering. --- Systems Biology. --- Computational Biology/Bioinformatics. --- Bioinformatics. --- Biological models. --- Biomedical engineering. --- Ingénierie --- Bio-informatique --- Modèles biologiques --- Génie biomédical --- Health & Biological Sciences --- Biomedical Engineering --- RNA-protein interactions. --- RNA polymerases. --- DNA-dependent RNA polymerases --- DNA-directed RNA polymerases --- Polymerases, RNA --- Ribonucleate nucleotidyltransferases --- RNA nucleotidyltransferases --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Systems biology. --- Protein binding --- Transferases --- Biomedical Engineering and Bioengineering. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Models, Biological --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Data processing --- Bioinformatics --- Biological systems --- Molecular biology

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Timing, racing, combating, struggling and targeting is some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ‘telomeres are messengers of NATURE’, let’s to know them as they are.

Aging Longevity. --- Telomere --- Telomerase --- Cancer cells --- Chromosome Structures --- Ribonucleoproteins --- RNA-Directed DNA Polymerase --- Diseases --- RNA-Binding Proteins --- DNA-Directed DNA Polymerase --- Genetic Structures --- Chromosomes --- Intranuclear Space --- DNA Nucleotidyltransferases --- Nucleoproteins --- Genetic Phenomena --- Carrier Proteins --- Phenomena and Processes --- Nucleotidyltransferases --- Cell Nucleus Structures --- Proteins --- Amino Acids, Peptides, and Proteins --- Cell Nucleus --- Phosphotransferases --- Transferases --- Chemicals and Drugs --- Intracellular Space --- Enzymes --- Cellular Structures --- Enzymes and Coenzymes --- Cells --- Anatomy --- Neoplasms --- Biology --- Health & Biological Sciences --- Cytology --- Telomere. --- Telomerase. --- Cancer cells. --- Medicine. --- Cancer research. --- Human genetics. --- Gene expression. --- Stem cells. --- Evolutionary biology. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Human Genetics. --- Gene Expression. --- Stem Cells. --- Evolutionary Biology. --- Pathology, Cellular --- DNA polymerases --- Oncology. --- Evolution (Biology). --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Expression --- Health Workforce --- Biomedicine, general. --- Cancer research