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This volume collects exciting new work in musicology.

Musicology. --- Music --- Musical research --- Research, Musical --- Popular music --- Research --- Historiography --- open access; oa; musicology

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In this work, the authors provide a contemporary and comprehensive discussion of osteoarthritis, explaining what the condition is, how patients can help themselves, and how to find the best resources to manage the disorder.

Osteoarthritis --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis

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Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis. Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury. Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology. This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.

Osteoarthritis --- Bone. --- Pathogenesis. --- Bones --- Calcification --- Connective tissues --- Skeleton --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis

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The most common form of arthritis is osteoarthritis (OA), which most often affects the hip, knee, foot and hand. The degeneration of joint cartilage and changes in underlying bone and supporting tissues such as ligament leads to pain, stiffness, movement problems and activity limitations. This book, containing three major sections in OA research and therapy, is an update of the book Osteoarthritis - Diagnosis, Treatment and Surgery published by InTech in 2012. The authors are experts in the osteoarthritis field, which include biologists, bioengineers, clinicians, and health professionals. The scientific content of the book will be beneficial to patients, students, researchers, educators, physicians, and health care providers who are interested in the recent progress in osteoarthritis research and therapy.

Osteoarthritis --- Treatment. --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis --- Immunology

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351-3036-7

415.4 --- Creativiteit --- Hersenen --- Leren --- Hogere geestelijke functies --- Gedrag --- algemene psychologie, hogere geestelijke functies (oa. leren, kennen, denken, begaafdheid, fantasie, geheugen, leerpsychologie)