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Pathology, Cellular

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The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.

Apoptosis. --- Pathology, Cellular.

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Virology. --- Pathology, Cellular.

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Pathology, Cellular. --- Histology, Pathological.

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Durch die rasante Entwicklung bildgebender Verfahren in der Gastroenterologie und der damit verbundenen Möglichkeit einer sehr sensitiven Gewinnung zytologischen Untersuchungsmaterials, hat sich die qualitative wie quantitative Anforderung an zytologische Untersuchungen weltweit erhöht. Während die "Klassiker" der klinischen Zytologie in ihrer Anwendung, z.B. in der Hämatologie, Pneumologie, Urologie u.a. als etabliert gelten, fehlen für die gastroenterologische Zytologie vergleichbare diagnostische Standards. Dieses Buch erklärt Internisten und insbesondere Gastroenterologen und Onkologen, wie auch Morphologen die diagnostische Wertigkeit zytologischer Befunde klinisch relevanter Organe. Darüber hinaus soll dem Kliniker die Möglichkeit einer eigenständigen zytologischen Befundung vor Ort vorgestellt werden.

Gastroenterology. --- Pathology, Cellular.