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Bioavailability. --- Availability, Biological --- Biological availability --- Physiologic availability --- Physiological availability --- Biochemistry

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This book begins with an overview of current thinking on bioavailability, its definition, cutting-edge research in speciation and advancement in tools for assessing chemical bioavailability in the terrestrial environment. The second section of the book focuses on the role of chemical speciation in bioavailability. Section three addresses bioavailability and ecotoxicity of contaminants and leads into the next section on bioavailability of nutrients and agrichemicals. Subsequent sections provide an overview of tools currently being used and new cutting-edge techniques to assess contaminant bioa

Soil biochemistry. --- Bioavailability. --- Availability, Biological --- Biological availability --- Physiologic availability --- Physiological availability --- Biochemistry --- Soil chemistry

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This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modeling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.   Vinod P. Shah is a pharmaceutical consultant. He was Scientific Secretary of the International Pharmaceutical Federation (FIP) and is now Chair of the FIP Regulatory Sciences Special Interest Group. Dr. Shah has served at the U.S. Food and Drug Administration and has developed several regulatory guidances for the pharmaceutical industry in biopharmaceutics and topical drug products. Howard I. Maibach is professor of dermatology at the University of California, San Francisco. He received his M.D. at Tulane University Medical School in New Orleans, Louisiana, and completed his residency and research fellowships at the University of Pennsylvania in Philadelphia, Pennsylvania. Professor Maibach is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted research and written extensively. John Jenner is a principal scientist at The Defence Science and Technology Laboratory in the UK. He has a degree in pharmacology from the University of Manchester in Manchester, UK, and a Ph.D. from the University of Surrey, Guildford, UK. John has spent his career studying defense against and treatment of highly toxic chemicals. He has an enduring research interest in percutaneously active chemicals, whether toxic materials or drugs, and experience in the design and testing of transdermal formulations.

Therapeutics, Cutaneous and external. --- Bioavailability. --- Drugs --- Skin --- Therapeutic equivalency. --- Permeability. --- Cutaneous permeability --- Skin permeability --- Bioequivalence in drugs --- Clinical equivalence in drugs --- Therapeutic equivalency in drugs --- Biopharmaceutics --- Availability, Biological --- Biological availability --- Physiologic availability --- Physiological availability --- Biochemistry --- Cutaneous therapeutics --- Equivalency, Therapeutic --- Toxicology. --- Animal physiology. --- Pharmacology/Toxicology. --- Animal Physiology. --- Biological and Medical Physics, Biophysics. --- Animal physiology --- Animals --- Biology --- Anatomy --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Physiology --- Toxicology --- Pharmacology. --- Biophysics. --- Biological physics. --- Biological physics --- Medical sciences --- Physics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect

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Publishes results and reviews on the chemical, biological, toxicological, and ecological effects of chemical species in the environment and on methodology for the determination of chemical species and their bioavailability.

Pollution --- Speciation (Chemistry) --- Bioavailability --- Environmental chemistry --- Environmental aspects --- Chemistry --- Engineering --- Environmental Sciences --- Life Sciences --- Environmental Chemistry --- Toxicology --- Environmental Engineering --- Ecosystems & Ecology --- Biochemistry --- Biology --- Availability, Biological --- Biological availability --- Physiologic availability --- Physiological availability --- Biochemical speciation --- Chemical speciation --- speciation analysis --- nutrients --- pollutants --- bioavailability --- biological uptake --- toxicity --- Bioavailability. --- Environmental chemistry. --- Pollution. --- Chemistry, Analytic --- Chemical pollution --- Contamination of environment --- Environmental pollution --- Contamination (Technology) --- Asbestos abatement --- Bioremediation --- Environmental engineering --- Environmental quality --- Factory and trade waste --- Hazardous waste site remediation --- Hazardous wastes --- In situ remediation --- Lead abatement --- Pollutants --- Refuse and refuse disposal --- Chemistry, Environmental --- Ecology --- Control --- Chemicals --- Analytical chemistry

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Drugs --- Oral medication. --- Pharmacokinetics. --- Biological Availability. --- Biopharmaceutics. --- Drug Therapy. --- Bioavailability. --- Absorption and adsorption. --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Pharmacologic Actions --- Pharmaceutics --- Pharmaceutic --- Chemistry, Pharmaceutical --- Availability, Biologic --- Availability, Biological --- Availability, Physiologic --- Biologic Availability --- Availability Equivalency --- Bioavailability --- Physiologic Availability --- Availabilities, Biologic --- Availabilities, Biological --- Availabilities, Physiologic --- Availability Equivalencies --- Bioavailabilities --- Biologic Availabilities --- Biological Availabilities --- Equivalencies, Availability --- Equivalency, Availability --- Physiologic Availabilities --- ADME --- ADME-Tox --- ADMET --- Absorption, Distribution, Metabolism, Elimination, and Toxicology --- Absorption, Distribution, Metabolism, and Elimination --- Drug Kinetics --- Kinetics, Drug --- LADMER --- Liberation, Absorption, Distribution, Metabolism, Elimination, and Response --- Drugs by mouth --- Medication, Oral --- Mouth, Medication by --- Peroral medication --- Therapeutics --- Drug bioavailability --- Biopharmaceutics --- drug therapy --- therapeutic use --- pharmacokinetics --- Administration --- Availability, Physiological --- Physiological availability