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Pharmacology. Therapy --- Analytical biochemistry --- Analysis of pharmaceuticals --- Pathological haematology --- Clinical chemistry --- Plasma proteins --- -Plasma proteins --- Serum proteins --- Blood plasma --- Serum --- Blood proteins --- -Proteins --- -577.112 Proteins --- 577.112 --- 577.112 Proteins --- Proteins --- Analysis --- Analysis. --- Blood Proteins --- analysis.

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Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspec-tive. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory cir-cuits. In this respect, scientists from around the world convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 5–10, 2005), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the "novel" functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Complement (Immunology) --- Blood proteins. --- Plasma proteins --- Serum proteins --- Blood plasma --- Proteins --- Serum --- Alexin --- Complements (Immunity) --- Blood proteins --- Immunology. --- Microbiology. --- Emerging infectious diseases. --- Pathology. --- Infectious Diseases. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Infectious diseases.

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Pathological biochemistry --- Pathological haematology --- Blood Proteins. --- Blood Protein Disorders --- Blood Protein Electrophoresis. --- Blood Protein Electrophoreses --- Electrophoreses, Blood Protein --- Electrophoresis, Blood Protein --- Protein Electrophoreses, Blood --- Protein Electrophoresis, Blood --- Immunoelectrophoresis --- Plasma Proteins --- Serum Proteins --- Proteins, Blood --- Proteins, Plasma --- Proteins, Serum --- Proteins --- physiopathology. --- blood --- Blood proteins --- BLOOD PROTEIN DISORDERS --- BLOOD PROTEIN ELECTROPHORESIS --- physiopathology --- Blood proteins. --- BLOOD PROTEIN ELECTROPHORESIS. --- Blood protein disorders --- Blood protein electrophoresis. --- Physiopathology. --- Hemoglobin Electrophoresis --- Electrophoresis, Hemoglobin --- Blood Protein --- Plasma Protein --- Serum Protein --- Protein, Blood --- Protein, Plasma --- Protein, Serum --- Blood Proteins --- Blood Protein Electrophoresis

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There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated – from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.

Carrier proteins. --- Cerebrospinal fluid proteins. --- Thyroid hormones. --- Thyroxine. --- Cerebrospinal fluid proteins --- Thyroxine --- Carrier proteins --- Thyroid hormones --- Evolution, Molecular --- Multiprotein Complexes --- Prealbumin --- Amyloidosis --- Macromolecular Substances --- Biological Evolution --- Serum Albumin --- Proteostasis Deficiencies --- Chemicals and Drugs --- Metabolic Diseases --- Biological Processes --- Genetic Processes --- Blood Proteins --- Albumins --- Nutritional and Metabolic Diseases --- Proteins --- Biological Phenomena --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Diseases --- Physiology --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Blood proteins --- Liver --- Metabolism. --- Secretions. --- Plasma proteins --- Serum proteins --- Medicine. --- Human physiology. --- Endocrinology. --- Proteomics. --- Biomedicine. --- Human Physiology. --- Abdomen --- Biliary tract --- Blood plasma --- Serum --- Human biology --- Medical sciences --- Human body --- Molecular biology --- Internal medicine --- Hormones --- Endocrinology .

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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States.  The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.

Prostate -- Cancer -- Diet therapy. --- Prostate -- Cancer -- Genetic aspects. --- Prostate -- Cancer -- Molecular aspects. --- Prostate --- Exocrine Glands --- Cell Physiological Processes --- Neoplastic Processes --- Prostatic Diseases --- Genital Neoplasms, Male --- Genitalia, Male --- Prostatic Secretory Proteins --- Tumor Markers, Biological --- Kallikreins --- Antigens, Neoplasm --- Biochemical Processes --- Proteins --- Seminal Plasma Proteins --- Genital Diseases, Male --- Neoplasms --- Biochemical Phenomena --- Biological Markers --- Pathologic Processes --- Genitalia --- Serine Endopeptidases --- Tissues --- Cell Physiological Phenomena --- Chemical Processes --- Antigens --- Amino Acids, Peptides, and Proteins --- Urogenital Neoplasms --- Neoplasms by Site --- Phenomena and Processes --- Chemical Phenomena --- Male Urogenital Diseases --- Biological Factors --- Endopeptidases --- Urogenital System --- Anatomy --- Diseases --- Chemicals and Drugs --- Serine Proteases --- Pathological Conditions, Signs and Symptoms --- Peptide Hydrolases --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Signal Transduction --- Prostatic Neoplasms --- Neoplasm Proteins --- Prostate-Specific Antigen --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Genetics. --- Cancer. --- Medicine. --- Cancer research. --- Medical biochemistry. --- Proteins. --- Cell biology. --- Systems biology. --- Biological systems. --- Biomedicine. --- Cancer Research. --- Medical Biochemistry. --- Cell Biology. --- Protein Science. --- Receptors. --- Biological Networks, Systems Biology. --- Biosystems --- Systems, Biological --- Biology --- System theory --- Systems biology --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Philosophy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Oncology. --- Biochemistry. --- Cytology. --- Cell receptors. --- Systems Biology. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Tumors --- Composition --- Proteins .