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The popular trope which depicts the origin of life on earth as emerging from a ?chemical soup? continues to have an enduring hold over the imagination. Of course, whether this ?soup? was a prebiotic puddle on the surface of this third rock from the Sun, originally ?canned?, superheated and pressurised in one of its internal faults, or a kind of extraterrestrial material reheated in some way after having reached the early Earth from elsewhere in universe, may not be known for sure. Nevertheless, advances in sciences such as paleogenomics and paleohistology have shown us that at least a part of the story of the origin of life can be traced in each and every cell of our living bodies.

Psychopharmacology.

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This greatly expanded third edition provides a comprehensive overview of clinical psychopharmacology, incorporating the major advances in the field since the previous edition's publication. Renowned experts from psychiatry, pharmacy, and nursing have integrated basic science, psychopharmacology, and clinical practice throughout the book in order to provide a thorough basis for prescribing. It covers all key psychiatric drugs and disorders and includes the latest data on efficacy, safety and tolerability. Adopting a pragmatic approach to drug nomenclature, both Neuroscience-based Nomenclature (NbN) and older generic terminology are included in the text reflecting that clinicians are likely to use both systems. Many chapters refer to current National Institute of Health and Care Excellence (NICE) guidelines, making this a crucial resource. Edited by leading authorities in the field, Professor Peter M. Haddad and Professor David J. Nutt, Seminars in Clinical Psychopharmacology emphasises evidence-based prescribing with the aim of achieving better clinical outcomes for patients.

Psychopharmacology.

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This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research. .

Psychopharmacology.

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Psychopharmacology.

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Psychopharmacology.