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Book
Beta-lactam resistance in gram-negative bacteria : threats and challenges
Authors: --- ---
ISBN: 9811690960 9811690979 Year: 2022 Publisher: Singapore : Springer,


Book
Antibiotic Resistant Bacteria: A Challenge to Modern Medicine
Authors: --- --- ---
ISBN: 9811398798 981139878X Year: 2019 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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Abstract

This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.


Book
Concepts and Principles of Pharmacology : 100 Years of the Handbook of Experimental Pharmacology
Authors: --- ---
ISBN: 3030353621 3030353613 Year: 2019 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Abstract

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.


Book
Rational Drug Design : Methods and Protocols
Authors: ---
ISBN: 1493986309 1493986295 Year: 2018 Publisher: New York, NY : Springer New York : Imprint: Humana,

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Abstract

This volume covers several aspects of rational drug design, such as synthesis of novel bioactive drugs; development and application of new methodologies; computational methods valuable for the establishment of new approaches in drug discovery; and the effects of physical-chemical and ADMET properties of the designed potential drugs. Chapters guide readers through amyloid deposits, Saturation Transfer Difference (STD) NMR, methods on bioguided design, the importance of lipophilicity in drug design, ADMET, FRET, structural biology, and homology modeling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Rational Drug Design: Methods and Protocols aims to ensure successful results in the further study of this vital field.

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