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Ribonucleases. --- Microorganisms.

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Bacterial Vaccines --- Pseudomonas aeruginosa --- Pseudomonas Infections --- Ribonucleases --- immunology --- immunology --- immunology --- physiology

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Nucleases --- Deoxyribonuclease --- Ribonuclease --- Phosphatases --- Congresses --- Nucleuses --- Nucleases. --- Congresses. --- Ribonucleases --- Phosphoric Monoester Hydrolases --- DNA Repair. --- DNA Replication. --- Nucleuses - Congresses --- DNA Repair --- DNA Replication --- Recombination, genetic --- Rna

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Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.

Ribonucleases -- Structure-activity relationships. --- Ribonucleases. --- Ribonucleases --- Esterases --- Biological Science Disciplines --- Natural Science Disciplines --- Hydrolases --- Disciplines and Occupations --- Enzymes --- Enzymes and Coenzymes --- Chemicals and Drugs --- Physiology --- Human Anatomy & Physiology --- Chemistry --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Animal Biochemistry --- Biochemistry --- RNases --- Life sciences. --- Molecular biology. --- Nucleic acids. --- Enzymology. --- Cell biology. --- Life Sciences. --- Nucleic Acid Chemistry. --- Cell Biology. --- Molecular Medicine. --- Nucleases --- Enzymes. --- Cytology. --- Medicine. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Polynucleotides --- Biomolecules --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Systems biology --- Biomaterials. --- Medicine --- Nucleic Acid. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

Ribonucleases. --- Ribosomes. --- RNA -- Metabolism. --- Ribonucleases --- RNA --- Ribosomes --- Metabolic Phenomena --- Biochemical Phenomena --- Nucleic Acids --- Exonucleases --- Chemical Phenomena --- Esterases --- Phenomena and Processes --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Exoribonucleases --- Metabolism --- RNA Stability --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Metabolism. --- Ribonucleoprotein particles --- Ribonucleic acid metabolism --- RNases --- Medicine. --- Molecular biology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Nucleases --- Health Workforce --- Biomedicine, general.